Inhibitory Effects of Dopamine Receptor D 1 Agonist on Mammary Tumor and Bone Metastasis

Dopaminergic signaling plays a critical role in the nervous system, but little is known about its potential role in breast cancer and bone metabolism. A screening of ~1,000 biologically active compounds revealed that a selective agonist of dopamine receptor D1 (DRD1), A77636, inhibited proliferation...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2017-04, Vol.7, p.45686
Hauptverfasser:	Minami, Kazumasa, Liu, Shengzhi, Liu, Yang, Chen, Andy, Wan, Qiaoqiao, Na, Sungsoo, Li, Bai-Yan, Matsuura, Nariaki, Koizumi, Masahiko, Yin, Yukun, Gan, Liangying, Xu, Aihua, Li, Jiliang, Nakshatri, Harikrishna, Yokota, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone and Bones - drug effects Bone and Bones - metabolism Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Breast Neoplasms Cell Line Cell Line, Tumor Dopamine Agonists - pharmacology Female Humans Mammary Neoplasms, Animal - drug therapy Mammary Neoplasms, Animal - metabolism Mice Neoplasm Metastasis - drug therapy Osteoclasts - drug effects Osteoclasts - metabolism RAW 264.7 Cells Receptors, Dopamine D1 - agonists Signal Transduction - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!