Role of plasma membrane-associated AKAPs for the regulation of cardiac I K1 current by protein kinase A

The cardiac I current stabilizes the resting membrane potential of cardiomyocytes. Protein kinase A (PKA) induces an inhibition of I current which strongly promotes focal arrhythmogenesis. The molecular mechanisms underlying this regulation have only partially been elucidated yet. Furthermore, the r...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2017-05, Vol.390 (5), p.493
Hauptverfasser:	Seyler, Claudia, Scherer, Daniel, Köpple, Christoph, Kulzer, Martin, Korkmaz, Sevil, Xynogalos, Panagiotis, Thomas, Dierk, Kaya, Ziya, Scholz, Eberhard, Backs, Johannes, Karle, Christoph, Katus, Hugo A, Zitron, Edgar
Format:	Artikel
Sprache:	eng
Schlagworte:	A Kinase Anchor Proteins - antagonists & inhibitors A Kinase Anchor Proteins - genetics A Kinase Anchor Proteins - metabolism Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Cell Membrane - drug effects Cell Membrane - enzymology CHO Cells Cricetulus Cyclic AMP-Dependent Protein Kinases - metabolism Enzyme Activation Enzyme Activators - pharmacology HEK293 Cells Humans Immunoprecipitation Ion Channel Gating Membrane Potentials Microinjections Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Patch-Clamp Techniques Peptides - pharmacology Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Protein Binding Rats Transfection Xenopus
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