SK2 channels regulate mitochondrial respiration and mitochondrial Ca 2+ uptake

Mitochondrial calcium ([Ca ] ) overload and changes in mitochondrial metabolism are key players in neuronal death. Small conductance calcium-activated potassium (SK) channels provide protection in different paradigms of neuronal cell death. Recently, SK channels were identified at the inner mitochon...

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Veröffentlicht in:	Cell death and differentiation 2017-05, Vol.24 (5), p.761
Hauptverfasser:	Honrath, Birgit, Matschke, Lina, Meyer, Tammo, Magerhans, Lena, Perocchi, Fabiana, Ganjam, Goutham K, Zischka, Hans, Krasel, Cornelius, Gerding, Albert, Bakker, Barbara M, Bünemann, Moritz, Strack, Stefan, Decher, Niels, Culmsee, Carsten, Dolga, Amalia M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aequorin - genetics Aequorin - metabolism Animals Apamin - pharmacology Calcium - metabolism Cell Death - drug effects Cell Line Cell Survival - drug effects Electron Transport Complex I - genetics Electron Transport Complex I - metabolism Fluorescence Resonance Energy Transfer Gene Expression Regulation Genes, Reporter Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Indoles - pharmacology Membrane Potential, Mitochondrial - drug effects Mice Mitochondria - drug effects Mitochondria - metabolism Neurons - cytology Neurons - drug effects Neurons - metabolism Oxidative Phosphorylation - drug effects Oximes - pharmacology Patch-Clamp Techniques Primary Cell Culture Pyrazoles - pharmacology Pyrimidines - pharmacology Rats Signal Transduction Small-Conductance Calcium-Activated Potassium Channels - agonists Small-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors Small-Conductance Calcium-Activated Potassium Channels - genetics Small-Conductance Calcium-Activated Potassium Channels - metabolism
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