Caspase 8 polymorphisms contribute to the prognosis of advanced lung adenocarcinoma patients after platinum-based chemotherapy

Lung cancer is the leading cause of cancer deaths in China, and about 60% of the cases are diagnosed with histological adenocarcinoma. The caspase 8 (CASP8) gene is a critical initiator of the extrinsic apoptosis pathway. To explore the relationship between tagSNPs or haplotypes of CASP8 and the eff...

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Veröffentlicht in:	Cancer biology & therapy 2017-12, Vol.18 (12), p.948-957
Hauptverfasser:	Liu, Di, Xu, Wen, Ding, Xi, Yang, Yang, Lu, Yanlin, Fei, Ke, Su, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - epidemiology Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung Adult Aged Aged, 80 and over Caspase 8 Caspase 8 - genetics chemotherapy China - epidemiology Disease-Free Survival Female Genotype Haplotypes Humans lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - epidemiology Lung Neoplasms - genetics Lung Neoplasms - pathology Male Middle Aged Neoplasm Staging platinum Platinum - administration & dosage Platinum - adverse effects Polymorphism, Single Nucleotide - genetics Prognosis Quality of Life Research Papers single nucleotide polymorphism
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