Cellular factories for coenzyme Q 10 production
Coenzyme Q (CoQ ), a benzoquinone present in most organisms, plays an important role in the electron-transport chain, and its deficiency is associated with various neuropathies and muscular disorders. CoQ is the only lipid-soluble antioxidant found in humans, and for this, it is gaining popularity i...
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| Veröffentlicht in: | Microbial cell factories 2017-03, Vol.16 (1), p.39 |
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| creator | Lee, Sean Qiu En Tan, Tsu Soo Kawamukai, Makoto Chen, Ee Sin |
| description | Coenzyme Q
(CoQ
), a benzoquinone present in most organisms, plays an important role in the electron-transport chain, and its deficiency is associated with various neuropathies and muscular disorders. CoQ
is the only lipid-soluble antioxidant found in humans, and for this, it is gaining popularity in the cosmetic and healthcare industries. To meet the growing demand for CoQ
, there has been considerable interest in ways to enhance its production, the most effective of which remains microbial fermentation. Previous attempts to increase CoQ
production to an industrial scale have thus far conformed to the strategies used in typical metabolic engineering endeavors. However, the emergence of new tools in the expanding field of synthetic biology has provided a suite of possibilities that extend beyond the traditional modes of metabolic engineering. In this review, we cover the various strategies currently undertaken to upscale CoQ
production, and discuss some of the potential novel areas for future research. |
| format | Article |
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(CoQ
), a benzoquinone present in most organisms, plays an important role in the electron-transport chain, and its deficiency is associated with various neuropathies and muscular disorders. CoQ
is the only lipid-soluble antioxidant found in humans, and for this, it is gaining popularity in the cosmetic and healthcare industries. To meet the growing demand for CoQ
, there has been considerable interest in ways to enhance its production, the most effective of which remains microbial fermentation. Previous attempts to increase CoQ
production to an industrial scale have thus far conformed to the strategies used in typical metabolic engineering endeavors. However, the emergence of new tools in the expanding field of synthetic biology has provided a suite of possibilities that extend beyond the traditional modes of metabolic engineering. In this review, we cover the various strategies currently undertaken to upscale CoQ
production, and discuss some of the potential novel areas for future research.</description><identifier>EISSN: 1475-2859</identifier><identifier>PMID: 28253886</identifier><language>eng</language><publisher>England</publisher><subject>Antioxidants - metabolism ; Fermentation ; Industrial Microbiology ; Metabolic Engineering - methods ; Protein Engineering - methods ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Ubiquinone - analogs & derivatives ; Ubiquinone - biosynthesis ; Vitamins - biosynthesis</subject><ispartof>Microbial cell factories, 2017-03, Vol.16 (1), p.39</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28253886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Sean Qiu En</creatorcontrib><creatorcontrib>Tan, Tsu Soo</creatorcontrib><creatorcontrib>Kawamukai, Makoto</creatorcontrib><creatorcontrib>Chen, Ee Sin</creatorcontrib><title>Cellular factories for coenzyme Q 10 production</title><title>Microbial cell factories</title><addtitle>Microb Cell Fact</addtitle><description>Coenzyme Q
(CoQ
), a benzoquinone present in most organisms, plays an important role in the electron-transport chain, and its deficiency is associated with various neuropathies and muscular disorders. CoQ
is the only lipid-soluble antioxidant found in humans, and for this, it is gaining popularity in the cosmetic and healthcare industries. To meet the growing demand for CoQ
, there has been considerable interest in ways to enhance its production, the most effective of which remains microbial fermentation. Previous attempts to increase CoQ
production to an industrial scale have thus far conformed to the strategies used in typical metabolic engineering endeavors. However, the emergence of new tools in the expanding field of synthetic biology has provided a suite of possibilities that extend beyond the traditional modes of metabolic engineering. In this review, we cover the various strategies currently undertaken to upscale CoQ
production, and discuss some of the potential novel areas for future research.</description><subject>Antioxidants - metabolism</subject><subject>Fermentation</subject><subject>Industrial Microbiology</subject><subject>Metabolic Engineering - methods</subject><subject>Protein Engineering - methods</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Ubiquinone - analogs & derivatives</subject><subject>Ubiquinone - biosynthesis</subject><subject>Vitamins - biosynthesis</subject><issn>1475-2859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpjYuA0NDE31TWyMLXkYOAqLs4yMDA0tzA3ZmfgMLIwMjW2sDDjZNB3Ts3JKc1JLFJIS0wuyS_KTC1WSMsvUkjOT82rqsxNVQhUMDRQKCjKTylNLsnMz-NhYE1LzClO5YXS3Axybq4hzh66BaVJuakp8QVFmbmJRZXxMBuMCSoAANFoL-4</recordid><startdate>20170302</startdate><enddate>20170302</enddate><creator>Lee, Sean Qiu En</creator><creator>Tan, Tsu Soo</creator><creator>Kawamukai, Makoto</creator><creator>Chen, Ee Sin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20170302</creationdate><title>Cellular factories for coenzyme Q 10 production</title><author>Lee, Sean Qiu En ; Tan, Tsu Soo ; Kawamukai, Makoto ; Chen, Ee Sin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_282538863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antioxidants - metabolism</topic><topic>Fermentation</topic><topic>Industrial Microbiology</topic><topic>Metabolic Engineering - methods</topic><topic>Protein Engineering - methods</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Saccharomyces cerevisiae - metabolism</topic><topic>Ubiquinone - analogs & derivatives</topic><topic>Ubiquinone - biosynthesis</topic><topic>Vitamins - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sean Qiu En</creatorcontrib><creatorcontrib>Tan, Tsu Soo</creatorcontrib><creatorcontrib>Kawamukai, Makoto</creatorcontrib><creatorcontrib>Chen, Ee Sin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Microbial cell factories</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Sean Qiu En</au><au>Tan, Tsu Soo</au><au>Kawamukai, Makoto</au><au>Chen, Ee Sin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular factories for coenzyme Q 10 production</atitle><jtitle>Microbial cell factories</jtitle><addtitle>Microb Cell Fact</addtitle><date>2017-03-02</date><risdate>2017</risdate><volume>16</volume><issue>1</issue><spage>39</spage><pages>39-</pages><eissn>1475-2859</eissn><abstract>Coenzyme Q
(CoQ
), a benzoquinone present in most organisms, plays an important role in the electron-transport chain, and its deficiency is associated with various neuropathies and muscular disorders. CoQ
is the only lipid-soluble antioxidant found in humans, and for this, it is gaining popularity in the cosmetic and healthcare industries. To meet the growing demand for CoQ
, there has been considerable interest in ways to enhance its production, the most effective of which remains microbial fermentation. Previous attempts to increase CoQ
production to an industrial scale have thus far conformed to the strategies used in typical metabolic engineering endeavors. However, the emergence of new tools in the expanding field of synthetic biology has provided a suite of possibilities that extend beyond the traditional modes of metabolic engineering. In this review, we cover the various strategies currently undertaken to upscale CoQ
production, and discuss some of the potential novel areas for future research.</abstract><cop>England</cop><pmid>28253886</pmid></addata></record> |
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| identifier | EISSN: 1475-2859 |
| ispartof | Microbial cell factories, 2017-03, Vol.16 (1), p.39 |
| issn | 1475-2859 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerNature Journals; PubMed Central Open Access; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Antioxidants - metabolism Fermentation Industrial Microbiology Metabolic Engineering - methods Protein Engineering - methods Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Ubiquinone - analogs & derivatives Ubiquinone - biosynthesis Vitamins - biosynthesis |
| title | Cellular factories for coenzyme Q 10 production |
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