High glucose dialysate enhances peritoneal fibrosis through upregulating glucose transporters GLUT1 and SGLT1

To investigate the role of glucose transporter 1 (GLUT1) and sodium-glucose cotransporter 1 (SGLT1) in high glucose dialysate-induced peritoneal fibrosis. Thirty six male SD rats were randomly divided into 6 groups (6 in each):normal control group, sham operation group, peritoneal dialysis group (PD...

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Veröffentlicht in:	Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban 2016-05, Vol.45 (6), p.598
Hauptverfasser:	Hong, Mengqi, Nie, Zhenyu, Chen, Zhengyue, Yu, Xiongwei, Bao, Beiyan
Format:	Artikel
Sprache:	chi
Schlagworte:	Animals Cells, Cultured Connective Tissue Growth Factor - analysis Connective Tissue Growth Factor - drug effects Dialysis Solutions - adverse effects Dialysis Solutions - chemistry Dialysis Solutions - pharmacology Gene Expression Regulation - drug effects Glucose - adverse effects Glucose - pharmacology Glucose Transporter Type 1 - analysis Glucose Transporter Type 1 - drug effects Glucose Transporter Type 1 - physiology Hemodiafiltration - adverse effects Hemodiafiltration - methods Humans Male Peritoneal Dialysis - adverse effects Peritoneal Dialysis - methods Peritoneal Fibrosis - chemically induced Peritoneal Fibrosis - genetics Peritoneal Fibrosis - physiopathology Peritoneum - chemistry Peritoneum - drug effects Peritoneum - pathology Phloretin Phlorhizin Rats Rats, Sprague-Dawley RNA, Messenger Sodium-Glucose Transporter 1 - analysis Sodium-Glucose Transporter 1 - drug effects Sodium-Glucose Transporter 1 - physiology Transforming Growth Factor beta1 - analysis Transforming Growth Factor beta1 - drug effects Uremia - chemically induced
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