High glucose dialysate enhances peritoneal fibrosis through upregulating glucose transporters GLUT1 and SGLT1
To investigate the role of glucose transporter 1 (GLUT1) and sodium-glucose cotransporter 1 (SGLT1) in high glucose dialysate-induced peritoneal fibrosis. Thirty six male SD rats were randomly divided into 6 groups (6 in each):normal control group, sham operation group, peritoneal dialysis group (PD...
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| Veröffentlicht in: | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban 2016-05, Vol.45 (6), p.598 |
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| container_title | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban |
| container_volume | 45 |
| creator | Hong, Mengqi Nie, Zhenyu Chen, Zhengyue Yu, Xiongwei Bao, Beiyan |
| description | To investigate the role of glucose transporter 1 (GLUT1) and sodium-glucose cotransporter 1 (SGLT1) in high glucose dialysate-induced peritoneal fibrosis.
Thirty six male SD rats were randomly divided into 6 groups (6 in each):normal control group, sham operation group, peritoneal dialysis group (PD group), PD+phloretin group (PD+T group), PD+phlorizin group (PD+Z group), PD+phloretin+phlorizin group (PD+T+Z group). Rat model of uraemia was established using 5/6 nephrotomy, and 2.5% dextrose peritoneal dialysis solution was used in peritoneal dialysis. Peritoneal equilibration test was performed 24 h after dialysis to evaluate transport function of peritoneum in rats; HE staining was used to observe the morphology of peritoneal tissue; and immunohistochemistry was used to detect the expression of GLUT1, SGLT1, TGF-β1 and connective tissue growth factor (CTGF) in peritoneum. Human peritoneal microvascular endothelial cells (HPECs) were divided into 5 groups:normal control group, peritoneal dialysis group (PD g |
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Thirty six male SD rats were randomly divided into 6 groups (6 in each):normal control group, sham operation group, peritoneal dialysis group (PD group), PD+phloretin group (PD+T group), PD+phlorizin group (PD+Z group), PD+phloretin+phlorizin group (PD+T+Z group). Rat model of uraemia was established using 5/6 nephrotomy, and 2.5% dextrose peritoneal dialysis solution was used in peritoneal dialysis. Peritoneal equilibration test was performed 24 h after dialysis to evaluate transport function of peritoneum in rats; HE staining was used to observe the morphology of peritoneal tissue; and immunohistochemistry was used to detect the expression of GLUT1, SGLT1, TGF-β1 and connective tissue growth factor (CTGF) in peritoneum. Human peritoneal microvascular endothelial cells (HPECs) were divided into 5 groups:normal control group, peritoneal dialysis group (PD g</description><identifier>ISSN: 1008-9292</identifier><identifier>PMID: 28247603</identifier><language>chi</language><publisher>China</publisher><subject>Animals ; Cells, Cultured ; Connective Tissue Growth Factor - analysis ; Connective Tissue Growth Factor - drug effects ; Dialysis Solutions - adverse effects ; Dialysis Solutions - chemistry ; Dialysis Solutions - pharmacology ; Gene Expression Regulation - drug effects ; Glucose - adverse effects ; Glucose - pharmacology ; Glucose Transporter Type 1 - analysis ; Glucose Transporter Type 1 - drug effects ; Glucose Transporter Type 1 - physiology ; Hemodiafiltration - adverse effects ; Hemodiafiltration - methods ; Humans ; Male ; Peritoneal Dialysis - adverse effects ; Peritoneal Dialysis - methods ; Peritoneal Fibrosis - chemically induced ; Peritoneal Fibrosis - genetics ; Peritoneal Fibrosis - physiopathology ; Peritoneum - chemistry ; Peritoneum - drug effects ; Peritoneum - pathology ; Phloretin ; Phlorhizin ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger ; Sodium-Glucose Transporter 1 - analysis ; Sodium-Glucose Transporter 1 - drug effects ; Sodium-Glucose Transporter 1 - physiology ; Transforming Growth Factor beta1 - analysis ; Transforming Growth Factor beta1 - drug effects ; Uremia - chemically induced</subject><ispartof>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2016-05, Vol.45 (6), p.598</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28247603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, Mengqi</creatorcontrib><creatorcontrib>Nie, Zhenyu</creatorcontrib><creatorcontrib>Chen, Zhengyue</creatorcontrib><creatorcontrib>Yu, Xiongwei</creatorcontrib><creatorcontrib>Bao, Beiyan</creatorcontrib><title>High glucose dialysate enhances peritoneal fibrosis through upregulating glucose transporters GLUT1 and SGLT1</title><title>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</title><addtitle>Zhejiang Da Xue Xue Bao Yi Xue Ban</addtitle><description>To investigate the role of glucose transporter 1 (GLUT1) and sodium-glucose cotransporter 1 (SGLT1) in high glucose dialysate-induced peritoneal fibrosis.
Thirty six male SD rats were randomly divided into 6 groups (6 in each):normal control group, sham operation group, peritoneal dialysis group (PD group), PD+phloretin group (PD+T group), PD+phlorizin group (PD+Z group), PD+phloretin+phlorizin group (PD+T+Z group). Rat model of uraemia was established using 5/6 nephrotomy, and 2.5% dextrose peritoneal dialysis solution was used in peritoneal dialysis. Peritoneal equilibration test was performed 24 h after dialysis to evaluate transport function of peritoneum in rats; HE staining was used to observe the morphology of peritoneal tissue; and immunohistochemistry was used to detect the expression of GLUT1, SGLT1, TGF-β1 and connective tissue growth factor (CTGF) in peritoneum. Human peritoneal microvascular endothelial cells (HPECs) were divided into 5 groups:normal control group, peritoneal dialysis group (PD g</description><subject>Animals</subject><subject>Cells, Cultured</subject><subject>Connective Tissue Growth Factor - analysis</subject><subject>Connective Tissue Growth Factor - drug effects</subject><subject>Dialysis Solutions - adverse effects</subject><subject>Dialysis Solutions - chemistry</subject><subject>Dialysis Solutions - pharmacology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Glucose - adverse effects</subject><subject>Glucose - pharmacology</subject><subject>Glucose Transporter Type 1 - analysis</subject><subject>Glucose Transporter Type 1 - drug effects</subject><subject>Glucose Transporter Type 1 - physiology</subject><subject>Hemodiafiltration - adverse effects</subject><subject>Hemodiafiltration - methods</subject><subject>Humans</subject><subject>Male</subject><subject>Peritoneal Dialysis - adverse effects</subject><subject>Peritoneal Dialysis - methods</subject><subject>Peritoneal Fibrosis - chemically induced</subject><subject>Peritoneal Fibrosis - genetics</subject><subject>Peritoneal Fibrosis - physiopathology</subject><subject>Peritoneum - chemistry</subject><subject>Peritoneum - drug effects</subject><subject>Peritoneum - pathology</subject><subject>Phloretin</subject><subject>Phlorhizin</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger</subject><subject>Sodium-Glucose Transporter 1 - analysis</subject><subject>Sodium-Glucose Transporter 1 - drug effects</subject><subject>Sodium-Glucose Transporter 1 - physiology</subject><subject>Transforming Growth Factor beta1 - analysis</subject><subject>Transforming Growth Factor beta1 - drug effects</subject><subject>Uremia - chemically induced</subject><issn>1008-9292</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j8lqwzAURbVoaUKaXyj6AYNmW8sSWqdg6KLOOjzZz7bAE5K8yN830IG7OKtz4D6QPWesyKywYkeOMXrHNJf5feyJ7EQhVG6Y3JPp7PuB9uPWLBFp62G8RUhIcR5gbjDSFYNPy4ww0s67sEQfaRrCst21bQ3YbyMkP_f_jRRgjusSEoZIy-pScwpzS7_KqubP5LGDMeLxlwdyeX-rT-es-iw_Tq9VtnJhUma5bNFw1nVSNwybXDZKO90KcAZQW2Vbx7VQymjeFcqC0pgzYYpcd0ygkwfy8tNdNzdhe12DnyDcrn-_5Td-EFWX</recordid><startdate>20160525</startdate><enddate>20160525</enddate><creator>Hong, Mengqi</creator><creator>Nie, Zhenyu</creator><creator>Chen, Zhengyue</creator><creator>Yu, Xiongwei</creator><creator>Bao, Beiyan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20160525</creationdate><title>High glucose dialysate enhances peritoneal fibrosis through upregulating glucose transporters GLUT1 and SGLT1</title><author>Hong, Mengqi ; Nie, Zhenyu ; Chen, Zhengyue ; Yu, Xiongwei ; Bao, Beiyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-913de610ff35c0ec73c45b5d2ab6ae5949db15244651f849a45e7026875f02eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Cells, Cultured</topic><topic>Connective Tissue Growth Factor - analysis</topic><topic>Connective Tissue Growth Factor - drug effects</topic><topic>Dialysis Solutions - adverse effects</topic><topic>Dialysis Solutions - chemistry</topic><topic>Dialysis Solutions - pharmacology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Glucose - adverse effects</topic><topic>Glucose - pharmacology</topic><topic>Glucose Transporter Type 1 - analysis</topic><topic>Glucose Transporter Type 1 - drug effects</topic><topic>Glucose Transporter Type 1 - physiology</topic><topic>Hemodiafiltration - adverse effects</topic><topic>Hemodiafiltration - methods</topic><topic>Humans</topic><topic>Male</topic><topic>Peritoneal Dialysis - adverse effects</topic><topic>Peritoneal Dialysis - methods</topic><topic>Peritoneal Fibrosis - chemically induced</topic><topic>Peritoneal Fibrosis - genetics</topic><topic>Peritoneal Fibrosis - physiopathology</topic><topic>Peritoneum - chemistry</topic><topic>Peritoneum - drug effects</topic><topic>Peritoneum - pathology</topic><topic>Phloretin</topic><topic>Phlorhizin</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger</topic><topic>Sodium-Glucose Transporter 1 - analysis</topic><topic>Sodium-Glucose Transporter 1 - drug effects</topic><topic>Sodium-Glucose Transporter 1 - physiology</topic><topic>Transforming Growth Factor beta1 - analysis</topic><topic>Transforming Growth Factor beta1 - drug effects</topic><topic>Uremia - chemically induced</topic><toplevel>online_resources</toplevel><creatorcontrib>Hong, Mengqi</creatorcontrib><creatorcontrib>Nie, Zhenyu</creatorcontrib><creatorcontrib>Chen, Zhengyue</creatorcontrib><creatorcontrib>Yu, Xiongwei</creatorcontrib><creatorcontrib>Bao, Beiyan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Mengqi</au><au>Nie, Zhenyu</au><au>Chen, Zhengyue</au><au>Yu, Xiongwei</au><au>Bao, Beiyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High glucose dialysate enhances peritoneal fibrosis through upregulating glucose transporters GLUT1 and SGLT1</atitle><jtitle>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</jtitle><addtitle>Zhejiang Da Xue Xue Bao Yi Xue Ban</addtitle><date>2016-05-25</date><risdate>2016</risdate><volume>45</volume><issue>6</issue><spage>598</spage><pages>598-</pages><issn>1008-9292</issn><abstract>To investigate the role of glucose transporter 1 (GLUT1) and sodium-glucose cotransporter 1 (SGLT1) in high glucose dialysate-induced peritoneal fibrosis.
Thirty six male SD rats were randomly divided into 6 groups (6 in each):normal control group, sham operation group, peritoneal dialysis group (PD group), PD+phloretin group (PD+T group), PD+phlorizin group (PD+Z group), PD+phloretin+phlorizin group (PD+T+Z group). Rat model of uraemia was established using 5/6 nephrotomy, and 2.5% dextrose peritoneal dialysis solution was used in peritoneal dialysis. Peritoneal equilibration test was performed 24 h after dialysis to evaluate transport function of peritoneum in rats; HE staining was used to observe the morphology of peritoneal tissue; and immunohistochemistry was used to detect the expression of GLUT1, SGLT1, TGF-β1 and connective tissue growth factor (CTGF) in peritoneum. Human peritoneal microvascular endothelial cells (HPECs) were divided into 5 groups:normal control group, peritoneal dialysis group (PD g</abstract><cop>China</cop><pmid>28247603</pmid></addata></record> |
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| ispartof | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2016-05, Vol.45 (6), p.598 |
| issn | 1008-9292 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Cells, Cultured Connective Tissue Growth Factor - analysis Connective Tissue Growth Factor - drug effects Dialysis Solutions - adverse effects Dialysis Solutions - chemistry Dialysis Solutions - pharmacology Gene Expression Regulation - drug effects Glucose - adverse effects Glucose - pharmacology Glucose Transporter Type 1 - analysis Glucose Transporter Type 1 - drug effects Glucose Transporter Type 1 - physiology Hemodiafiltration - adverse effects Hemodiafiltration - methods Humans Male Peritoneal Dialysis - adverse effects Peritoneal Dialysis - methods Peritoneal Fibrosis - chemically induced Peritoneal Fibrosis - genetics Peritoneal Fibrosis - physiopathology Peritoneum - chemistry Peritoneum - drug effects Peritoneum - pathology Phloretin Phlorhizin Rats Rats, Sprague-Dawley RNA, Messenger Sodium-Glucose Transporter 1 - analysis Sodium-Glucose Transporter 1 - drug effects Sodium-Glucose Transporter 1 - physiology Transforming Growth Factor beta1 - analysis Transforming Growth Factor beta1 - drug effects Uremia - chemically induced |
| title | High glucose dialysate enhances peritoneal fibrosis through upregulating glucose transporters GLUT1 and SGLT1 |
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