Severe Convulsions and Dysmyelination in Both Jimpy and Cx32/47 -/- Mice may Associate Astrocytic L-Channel Function with Myelination and Oligodendrocytic Connexins with Internodal K v Channels

The Jimpy mouse illustrates the importance of interactions between astrocytes and oligodendrocytes. It has a mutation in Plp coding for proteolipid protein and DM20. Its behavior is normal at birth but from the age of ~2 weeks it shows severe convulsions associated with oligodendrocyte/myelination d...

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Veröffentlicht in:	Neurochemical research 2017-06, Vol.42 (6), p.1747
Hauptverfasser:	Chaban, Y H Gerald, Chen, Ye, Hertz, Elna, Hertz, Leif
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - metabolism Astrocytes - pathology Connexins - deficiency Connexins - genetics Demyelinating Diseases - genetics Demyelinating Diseases - metabolism Demyelinating Diseases - pathology Gap Junction beta-1 Protein Humans Mice Mice, Jimpy Myelin Sheath - genetics Myelin Sheath - metabolism Myelin Sheath - pathology Oligodendroglia - metabolism Oligodendroglia - pathology Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Seizures - genetics Seizures - metabolism Seizures - pathology Sodium-Potassium-Exchanging ATPase - deficiency Sodium-Potassium-Exchanging ATPase - genetics
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