Enhancing VTA Ca v 1.3 L-type Ca 2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens

Genetic factors significantly influence susceptibility for substance abuse and mood disorders. Rodent studies have begun to elucidate a role of Ca 1.3 L-type Ca channels in neuropsychiatric-related behaviors, such as addictive and depressive-like behaviors. Human studies have also linked the CACNA1D...

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Veröffentlicht in:	Molecular psychiatry 2017-12, Vol.22 (12), p.1735
Hauptverfasser:	Martínez-Rivera, A, Hao, J, Tropea, T F, Giordano, T P, Kosovsky, M, Rice, R C, Lee, A, Huganir, R L, Striessnig, J, Addy, N A, Han, S, Rajadhyaksha, A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Affect - drug effects Affect - physiology Animals Calcium Channels, L-Type - genetics Calcium Channels, L-Type - metabolism Cocaine - pharmacology Cocaine-Related Disorders - metabolism Conditioning, Psychological - drug effects Conditioning, Psychological - physiology Depression - metabolism Disease Models, Animal Dopamine Uptake Inhibitors - pharmacology Genetic Association Studies Humans Male Mice, Inbred C57BL Mice, Transgenic Motor Activity - drug effects Motor Activity - physiology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Post-Synaptic Density - drug effects Post-Synaptic Density - metabolism Receptors, AMPA - metabolism Social Behavior Ventral Tegmental Area - drug effects Ventral Tegmental Area - metabolism
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