One-pot synthesis of novel (2R,4S)-N-aryl-4-hydroxy-1-(2,2,2-trifluoroacetyl) pyrrolidine-2-carboxamides via [Formula: see text]-NPs and [Formula: see text] catalysts and investigation of their biological activities
A new class of (2R,4S)-N-aryl-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide compounds was synthesized by a facile one-pot reaction of trans-4-hydroxy proline and trifluoroacetimidoyl chlorides in the presence of [Formula: see text]-nanoparticles as a catalyst and sodium bicarbonate as...
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| Veröffentlicht in: | Molecular diversity 2017-05, Vol.21 (2), p.305 |
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| creator | Darehkordi, Ali Ramezani, Mahin |
| description | A new class of (2R,4S)-N-aryl-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide compounds was synthesized by a facile one-pot reaction of trans-4-hydroxy proline and trifluoroacetimidoyl chlorides in the presence of [Formula: see text]-nanoparticles as a catalyst and sodium bicarbonate as a base. Synthesized compounds showed cytotoxicity with [Formula: see text] values of 15.3-70.3 [Formula: see text] against K562 (Homo sapiens, human) cells. The results of the study provide a valuable method for one-pot synthesis of trans-4-hydroxy proline-based N-(2,2,2-trifluoroacetylated) compounds. Also, these compounds show significant pharmaceutical activities as antibacterial and antifungal reagents. |
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Synthesized compounds showed cytotoxicity with [Formula: see text] values of 15.3-70.3 [Formula: see text] against K562 (Homo sapiens, human) cells. The results of the study provide a valuable method for one-pot synthesis of trans-4-hydroxy proline-based N-(2,2,2-trifluoroacetylated) compounds. 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| identifier | EISSN: 1573-501X |
| ispartof | Molecular diversity, 2017-05, Vol.21 (2), p.305 |
| issn | 1573-501X |
| language | eng |
| recordid | cdi_pubmed_primary_28190224 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Catalysis Chemistry Techniques, Synthetic Drug Design Humans Inhibitory Concentration 50 K562 Cells Microbial Sensitivity Tests Nanoparticles - chemistry Organometallic Compounds - chemistry Palladium - chemistry Pyrrolidines - chemical synthesis Pyrrolidines - chemistry Pyrrolidines - pharmacology Titanium - chemistry |
| title | One-pot synthesis of novel (2R,4S)-N-aryl-4-hydroxy-1-(2,2,2-trifluoroacetyl) pyrrolidine-2-carboxamides via [Formula: see text]-NPs and [Formula: see text] catalysts and investigation of their biological activities |
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