MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase

MicroRNAs (miRs) have been demonstrated to be involved in the development and progression of osteosarcoma (OS), but the molecular mechanism still remains to be fully investigated. The present study investigated the function of miR-148a in OS, as well as its underlying mechanism. Our data showed that...

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Veröffentlicht in:	Oncology research 2017-09, Vol.25 (8), p.1231-1243
Hauptverfasser:	Yang, HaiYan, Peng, ZhiGang, Da, ZhenZhen, Li, Xin, Cheng, YeXiao, Tan, BinBin, Xiang, Xin, Zheng, HaiPing, Li, Yan, Chen, LanHua, Mo, Ning, Yan, XueXin, Li, Xiaolin, Hu, XiaoHua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Bone Neoplasms - enzymology Bone Neoplasms - genetics Cell Line, Tumor Female Genes, Tumor Suppressor Heterografts Humans Male Mice Mice, Inbred BALB C Mice, Nude Micrornas (mirs) MicroRNAs - genetics Osteosarcoma Osteosarcoma - enzymology Osteosarcoma - genetics Rho-Associated Coiled-Coil Kinase 1 (rock1) rho-Associated Kinases - genetics rho-Associated Kinases - metabolism Transfection Tumor Suppressor Young Adult
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