Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium
Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1 mg CdCl 2 /kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 2...
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| Veröffentlicht in: | Journal of enzyme inhibition and medicinal chemistry 2017-01, Vol.32 (1), p.478-489 |
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| creator | Begic, Aida Djuric, Ana Ninkovic, Milica Stevanovic, Ivana Djurdjevic, Dragan Pavlovic, Milos Jelic, Katarina Pantelic, Ana Zebic, Goran Dejanovic, Bratislav Stanojevic, Ivan Vojvodic, Danilo Milosavljevic, Petar Djukic, Mirjana Saso, Luciano |
| description | Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1 mg CdCl
2
/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O
2
·−
) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact. |
| doi_str_mv | 10.1080/14756366.2016.1261132 |
| format | Article |
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2
/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O
2
·−
) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact.</description><identifier>ISSN: 1475-6366</identifier><identifier>EISSN: 1475-6374</identifier><identifier>DOI: 10.1080/14756366.2016.1261132</identifier><identifier>PMID: 28102089</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Alanine ; Animals ; Cadmium ; Cadmium - toxicity ; Cadmium chloride ; Catalase ; Disulfiram ; Disulfiram - pharmacology ; essential metals ; Glutathione peroxidase ; Glutathione reductase ; Glutathione transferase ; hepatotoxicity ; Liver ; Liver - drug effects ; Liver - metabolism ; Magnesium ; Male ; Malondialdehyde ; Oxidation-Reduction ; Oxidative Stress ; Rats ; Rats, Wistar ; Rodents ; Superoxide dismutase ; Toxicity</subject><ispartof>Journal of enzyme inhibition and medicinal chemistry, 2017-01, Vol.32 (1), p.478-489</ispartof><rights>2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2017</rights><rights>2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2017 The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-9476ac67b96ed68a4fc3fef892ac7ffb95608a15a7b48139fa94d6d206bce0513</citedby><cites>FETCH-LOGICAL-c562t-9476ac67b96ed68a4fc3fef892ac7ffb95608a15a7b48139fa94d6d206bce0513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010100/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010100/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27481,27903,27904,53769,53771,59119,59120</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28102089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Begic, Aida</creatorcontrib><creatorcontrib>Djuric, Ana</creatorcontrib><creatorcontrib>Ninkovic, Milica</creatorcontrib><creatorcontrib>Stevanovic, Ivana</creatorcontrib><creatorcontrib>Djurdjevic, Dragan</creatorcontrib><creatorcontrib>Pavlovic, Milos</creatorcontrib><creatorcontrib>Jelic, Katarina</creatorcontrib><creatorcontrib>Pantelic, Ana</creatorcontrib><creatorcontrib>Zebic, Goran</creatorcontrib><creatorcontrib>Dejanovic, Bratislav</creatorcontrib><creatorcontrib>Stanojevic, Ivan</creatorcontrib><creatorcontrib>Vojvodic, Danilo</creatorcontrib><creatorcontrib>Milosavljevic, Petar</creatorcontrib><creatorcontrib>Djukic, Mirjana</creatorcontrib><creatorcontrib>Saso, Luciano</creatorcontrib><title>Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium</title><title>Journal of enzyme inhibition and medicinal chemistry</title><addtitle>J Enzyme Inhib Med Chem</addtitle><description>Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1 mg CdCl
2
/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O
2
·−
) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact.</description><subject>Alanine</subject><subject>Animals</subject><subject>Cadmium</subject><subject>Cadmium - toxicity</subject><subject>Cadmium chloride</subject><subject>Catalase</subject><subject>Disulfiram</subject><subject>Disulfiram - pharmacology</subject><subject>essential metals</subject><subject>Glutathione peroxidase</subject><subject>Glutathione reductase</subject><subject>Glutathione transferase</subject><subject>hepatotoxicity</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Magnesium</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Superoxide dismutase</subject><subject>Toxicity</subject><issn>1475-6366</issn><issn>1475-6374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp9UUtv1DAQjhCIlsJPAEXivIvtOGP7gkClQKVKXOBsTfzoepXEwU5K99_Xy25X9IIs2dbM9_D4q6q3lKwpkeQD5aKFBmDNCIU1ZUBpw55V5_v6ChrBn5_uAGfVq5y3hDDKKH9ZnTFJCSNSnVf-S8hL70PCoR6idQln1-_q5PIcy1aHYcKQnK03bsI5mNKx8b7OM85LrqOvCyHXeenMJsUxGOwL291PMRfOHGuDdgjL8Lp64bHP7s3xvKh-fb36efl9dfPj2_Xl55uVaYHNK8UFoAHRKXAWJHJvGu-8VAyN8L5TLRCJtEXRcUkb5VFxC5YR6IwjLW0uquuDro241VMKA6adjhj030JMtxpTGaN32oJyrW0FV0xwhl4aprwE8ByYRyeK1seD1rR0g7PGjXPC_ono084YNvo23mkgtCxSBN4fBVL8vZQf1du4pLHMrxlVLWsY4Xub9oAyKeacnD85UKL3UevHqPU-an2MuvDe_fu8E-sx2wL4dACE0cc04J-Yeqtn3PUx-YSjCVk3__d4AEfauwc</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Begic, Aida</creator><creator>Djuric, Ana</creator><creator>Ninkovic, Milica</creator><creator>Stevanovic, Ivana</creator><creator>Djurdjevic, Dragan</creator><creator>Pavlovic, Milos</creator><creator>Jelic, Katarina</creator><creator>Pantelic, Ana</creator><creator>Zebic, Goran</creator><creator>Dejanovic, Bratislav</creator><creator>Stanojevic, Ivan</creator><creator>Vojvodic, Danilo</creator><creator>Milosavljevic, Petar</creator><creator>Djukic, Mirjana</creator><creator>Saso, Luciano</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170101</creationdate><title>Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium</title><author>Begic, Aida ; Djuric, Ana ; Ninkovic, Milica ; Stevanovic, Ivana ; Djurdjevic, Dragan ; Pavlovic, Milos ; Jelic, Katarina ; Pantelic, Ana ; Zebic, Goran ; Dejanovic, Bratislav ; Stanojevic, Ivan ; Vojvodic, Danilo ; Milosavljevic, Petar ; Djukic, Mirjana ; Saso, Luciano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-9476ac67b96ed68a4fc3fef892ac7ffb95608a15a7b48139fa94d6d206bce0513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alanine</topic><topic>Animals</topic><topic>Cadmium</topic><topic>Cadmium - toxicity</topic><topic>Cadmium chloride</topic><topic>Catalase</topic><topic>Disulfiram</topic><topic>Disulfiram - pharmacology</topic><topic>essential metals</topic><topic>Glutathione peroxidase</topic><topic>Glutathione reductase</topic><topic>Glutathione transferase</topic><topic>hepatotoxicity</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Magnesium</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Superoxide dismutase</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Begic, Aida</creatorcontrib><creatorcontrib>Djuric, Ana</creatorcontrib><creatorcontrib>Ninkovic, Milica</creatorcontrib><creatorcontrib>Stevanovic, Ivana</creatorcontrib><creatorcontrib>Djurdjevic, Dragan</creatorcontrib><creatorcontrib>Pavlovic, Milos</creatorcontrib><creatorcontrib>Jelic, Katarina</creatorcontrib><creatorcontrib>Pantelic, Ana</creatorcontrib><creatorcontrib>Zebic, Goran</creatorcontrib><creatorcontrib>Dejanovic, Bratislav</creatorcontrib><creatorcontrib>Stanojevic, Ivan</creatorcontrib><creatorcontrib>Vojvodic, Danilo</creatorcontrib><creatorcontrib>Milosavljevic, Petar</creatorcontrib><creatorcontrib>Djukic, Mirjana</creatorcontrib><creatorcontrib>Saso, Luciano</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of enzyme inhibition and medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Begic, Aida</au><au>Djuric, Ana</au><au>Ninkovic, Milica</au><au>Stevanovic, Ivana</au><au>Djurdjevic, Dragan</au><au>Pavlovic, Milos</au><au>Jelic, Katarina</au><au>Pantelic, Ana</au><au>Zebic, Goran</au><au>Dejanovic, Bratislav</au><au>Stanojevic, Ivan</au><au>Vojvodic, Danilo</au><au>Milosavljevic, Petar</au><au>Djukic, Mirjana</au><au>Saso, Luciano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium</atitle><jtitle>Journal of enzyme inhibition and medicinal chemistry</jtitle><addtitle>J Enzyme Inhib Med Chem</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>32</volume><issue>1</issue><spage>478</spage><epage>489</epage><pages>478-489</pages><issn>1475-6366</issn><eissn>1475-6374</eissn><abstract>Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1 mg CdCl
2
/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O
2
·−
) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>28102089</pmid><doi>10.1080/14756366.2016.1261132</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alanine Animals Cadmium Cadmium - toxicity Cadmium chloride Catalase Disulfiram Disulfiram - pharmacology essential metals Glutathione peroxidase Glutathione reductase Glutathione transferase hepatotoxicity Liver Liver - drug effects Liver - metabolism Magnesium Male Malondialdehyde Oxidation-Reduction Oxidative Stress Rats Rats, Wistar Rodents Superoxide dismutase Toxicity |
| title | Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium |
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