Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca 2+ signalling

Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances the retraction of cancer-associated fibroblasts (CAFs) and therefore, 12(S)-HETE may enforce invasivity of CRC. Understanding the mechanisms...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2017-05, Vol.74 (10), p.1907
Hauptverfasser:	Stadler, Serena, Nguyen, Chi Huu, Schachner, Helga, Milovanovic, Daniela, Holzner, Silvio, Brenner, Stefan, Eichsteininger, Julia, Stadler, Mira, Senfter, Daniel, Krenn, Liselotte, Schmidt, Wolfgang M, Huttary, Nicole, Krieger, Sigurd, Koperek, Oskar, Bago-Horvath, Zsuzsanna, Brendel, Konstantin Alexander, Marian, Brigitte, de Wever, Oliver, Mader, Robert M, Giessrigl, Benedikt, Jäger, Walter, Dolznig, Helmut, Krupitza, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - metabolism Calcium - metabolism Cancer-Associated Fibroblasts - metabolism Cancer-Associated Fibroblasts - pathology Cardiac Myosins - metabolism Cell Line, Tumor Cell Movement Colon - metabolism Colon - pathology Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Humans Myosin Light Chains - metabolism Neoplasm Invasiveness - pathology Rectum - metabolism Rectum - pathology rho-Associated Kinases - metabolism Signal Transduction
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