Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy
A combination of approaches to the image analysis in cross-polarization optical coherence tomography (CP OCT) and high-resolution imaging by nonlinear microscopy and atomic force microscopy (AFM) at the different stages of atherosclerotic plaque development is studied. This combination allowed us to...
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| Veröffentlicht in: | Journal of biomedical optics 2016-12, Vol.21 (12), p.126010-126010 |
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| container_title | Journal of biomedical optics |
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| creator | Gubarkova, Ekaterina V Kirillin, Mikhail Yu Dudenkova, Varvara V Timashev, Peter S Kotova, Svetlana L Kiseleva, Elena B Timofeeva, Lidia B Belkova, Galina V Solovieva, Anna B Moiseev, Alexander A Gelikonov, Gregory V Fiks, Ilya I Feldchtein, Felix I Gladkova, Natalia D |
| description | A combination of approaches to the image analysis in cross-polarization optical coherence tomography (CP OCT) and high-resolution imaging by nonlinear microscopy and atomic force microscopy (AFM) at the different stages of atherosclerotic plaque development is studied. This combination allowed us to qualitatively and quantitatively assess the disorganization of collagen in the atherosclerotic arterial tissue (reduction and increase of CP backscatter), at the fiber (change of the geometric distribution of fibers in the second-harmonic generation microscopy images) and fibrillar (violation of packing and different nature of a basket-weave network of fibrils in the AFM images) organization levels. The calculated CP channel-related parameters are shown to have a statistically significant difference between stable and unstable (also called vulnerable) plaques, and hence, CP OCT could be a potentially powerful, minimally invasive method for vulnerable plaques detection. |
| doi_str_mv | 10.1117/1.JBO.21.12.126010 |
| format | Article |
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This combination allowed us to qualitatively and quantitatively assess the disorganization of collagen in the atherosclerotic arterial tissue (reduction and increase of CP backscatter), at the fiber (change of the geometric distribution of fibers in the second-harmonic generation microscopy images) and fibrillar (violation of packing and different nature of a basket-weave network of fibrils in the AFM images) organization levels. The calculated CP channel-related parameters are shown to have a statistically significant difference between stable and unstable (also called vulnerable) plaques, and hence, CP OCT could be a potentially powerful, minimally invasive method for vulnerable plaques detection.</description><identifier>ISSN: 1083-3668</identifier><identifier>EISSN: 1560-2281</identifier><identifier>DOI: 10.1117/1.JBO.21.12.126010</identifier><identifier>PMID: 27997633</identifier><language>eng</language><publisher>United States: Society of Photo-Optical Instrumentation Engineers</publisher><subject>Algorithms ; Collagen ; Coronary Vessels - diagnostic imaging ; Humans ; Image Interpretation, Computer-Assisted - methods ; Microscopy, Atomic Force - methods ; Plaque, Atherosclerotic - diagnostic imaging ; Tomography, Optical Coherence - methods</subject><ispartof>Journal of biomedical optics, 2016-12, Vol.21 (12), p.126010-126010</ispartof><rights>2016 Society of Photo-Optical Instrumentation Engineers (SPIE)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-62cb77413f5a3015370448f48571b6a270a71d25f0e7051a676558b42f11f78e3</citedby><cites>FETCH-LOGICAL-c467t-62cb77413f5a3015370448f48571b6a270a71d25f0e7051a676558b42f11f78e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27997633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gubarkova, Ekaterina V</creatorcontrib><creatorcontrib>Kirillin, Mikhail Yu</creatorcontrib><creatorcontrib>Dudenkova, Varvara V</creatorcontrib><creatorcontrib>Timashev, Peter S</creatorcontrib><creatorcontrib>Kotova, Svetlana L</creatorcontrib><creatorcontrib>Kiseleva, Elena B</creatorcontrib><creatorcontrib>Timofeeva, Lidia B</creatorcontrib><creatorcontrib>Belkova, Galina V</creatorcontrib><creatorcontrib>Solovieva, Anna B</creatorcontrib><creatorcontrib>Moiseev, Alexander A</creatorcontrib><creatorcontrib>Gelikonov, Gregory V</creatorcontrib><creatorcontrib>Fiks, Ilya I</creatorcontrib><creatorcontrib>Feldchtein, Felix I</creatorcontrib><creatorcontrib>Gladkova, Natalia D</creatorcontrib><title>Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy</title><title>Journal of biomedical optics</title><addtitle>J. Biomed. Opt</addtitle><description>A combination of approaches to the image analysis in cross-polarization optical coherence tomography (CP OCT) and high-resolution imaging by nonlinear microscopy and atomic force microscopy (AFM) at the different stages of atherosclerotic plaque development is studied. This combination allowed us to qualitatively and quantitatively assess the disorganization of collagen in the atherosclerotic arterial tissue (reduction and increase of CP backscatter), at the fiber (change of the geometric distribution of fibers in the second-harmonic generation microscopy images) and fibrillar (violation of packing and different nature of a basket-weave network of fibrils in the AFM images) organization levels. The calculated CP channel-related parameters are shown to have a statistically significant difference between stable and unstable (also called vulnerable) plaques, and hence, CP OCT could be a potentially powerful, minimally invasive method for vulnerable plaques detection.</description><subject>Algorithms</subject><subject>Collagen</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Microscopy, Atomic Force - methods</subject><subject>Plaque, Atherosclerotic - diagnostic imaging</subject><subject>Tomography, Optical Coherence - methods</subject><issn>1083-3668</issn><issn>1560-2281</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1vVCEQhonR2Fr9A14YLr3o2TJw-NjLWq0faVJNNF4S9iy0NBxAOKfJ9lf4k2W7qzGpMSEwYd73gZlB6CWQBQDIE1h8enO5oLAA2pYgQB6hQ-CCdJQqeNxioljHhFAH6FmtN4QQJZbiKTqgcrmUgrFD9PPLbOLkJzP5W4vtrQlzC1PEyWEzXduS6hDaPvkB52B-zLbiufp4hYeWql1OwRR_t_fkJjMBD6kZbRwsntKYrorJ15tjHFMMPlpTjrGJ60ZPY4O6VJquRduXUt48R0-cCdW-2J9H6Nv5u69nH7qLy_cfz04vuqEXcuoEHVZS9sAcN4wAZ5L0vXK94hJWwlBJjIQ15Y5YSTgYIQXnatVTB-CksuwIvd5xc0nbqiY9-jrYEEy0aa4aFAdGmCLLJqU76X3JxTqdix9N2WggejsJDbpNQlPQQPVuEs30as-fV6Nd_7H8bn0TfN8JavZW36S5xFbvX6A7nx9g7y9PS2tzsJ_fnj_M57Vr5JN_kf_z2V9V57Fm</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Gubarkova, Ekaterina V</creator><creator>Kirillin, Mikhail Yu</creator><creator>Dudenkova, Varvara V</creator><creator>Timashev, Peter S</creator><creator>Kotova, Svetlana L</creator><creator>Kiseleva, Elena B</creator><creator>Timofeeva, Lidia B</creator><creator>Belkova, Galina V</creator><creator>Solovieva, Anna B</creator><creator>Moiseev, Alexander A</creator><creator>Gelikonov, Gregory V</creator><creator>Fiks, Ilya I</creator><creator>Feldchtein, Felix I</creator><creator>Gladkova, Natalia D</creator><general>Society of Photo-Optical Instrumentation Engineers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy</title><author>Gubarkova, Ekaterina V ; Kirillin, Mikhail Yu ; Dudenkova, Varvara V ; Timashev, Peter S ; Kotova, Svetlana L ; Kiseleva, Elena B ; Timofeeva, Lidia B ; Belkova, Galina V ; Solovieva, Anna B ; Moiseev, Alexander A ; Gelikonov, Gregory V ; Fiks, Ilya I ; Feldchtein, Felix I ; Gladkova, Natalia D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-62cb77413f5a3015370448f48571b6a270a71d25f0e7051a676558b42f11f78e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Algorithms</topic><topic>Collagen</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Microscopy, Atomic Force - methods</topic><topic>Plaque, Atherosclerotic - diagnostic imaging</topic><topic>Tomography, Optical Coherence - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gubarkova, Ekaterina V</creatorcontrib><creatorcontrib>Kirillin, Mikhail Yu</creatorcontrib><creatorcontrib>Dudenkova, Varvara V</creatorcontrib><creatorcontrib>Timashev, Peter S</creatorcontrib><creatorcontrib>Kotova, Svetlana L</creatorcontrib><creatorcontrib>Kiseleva, Elena B</creatorcontrib><creatorcontrib>Timofeeva, Lidia B</creatorcontrib><creatorcontrib>Belkova, Galina V</creatorcontrib><creatorcontrib>Solovieva, Anna B</creatorcontrib><creatorcontrib>Moiseev, Alexander A</creatorcontrib><creatorcontrib>Gelikonov, Gregory V</creatorcontrib><creatorcontrib>Fiks, Ilya I</creatorcontrib><creatorcontrib>Feldchtein, Felix I</creatorcontrib><creatorcontrib>Gladkova, Natalia D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gubarkova, Ekaterina V</au><au>Kirillin, Mikhail Yu</au><au>Dudenkova, Varvara V</au><au>Timashev, Peter S</au><au>Kotova, Svetlana L</au><au>Kiseleva, Elena B</au><au>Timofeeva, Lidia B</au><au>Belkova, Galina V</au><au>Solovieva, Anna B</au><au>Moiseev, Alexander A</au><au>Gelikonov, Gregory V</au><au>Fiks, Ilya I</au><au>Feldchtein, Felix I</au><au>Gladkova, Natalia D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy</atitle><jtitle>Journal of biomedical optics</jtitle><addtitle>J. Biomed. Opt</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>21</volume><issue>12</issue><spage>126010</spage><epage>126010</epage><pages>126010-126010</pages><issn>1083-3668</issn><eissn>1560-2281</eissn><abstract>A combination of approaches to the image analysis in cross-polarization optical coherence tomography (CP OCT) and high-resolution imaging by nonlinear microscopy and atomic force microscopy (AFM) at the different stages of atherosclerotic plaque development is studied. This combination allowed us to qualitatively and quantitatively assess the disorganization of collagen in the atherosclerotic arterial tissue (reduction and increase of CP backscatter), at the fiber (change of the geometric distribution of fibers in the second-harmonic generation microscopy images) and fibrillar (violation of packing and different nature of a basket-weave network of fibrils in the AFM images) organization levels. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Algorithms Collagen Coronary Vessels - diagnostic imaging Humans Image Interpretation, Computer-Assisted - methods Microscopy, Atomic Force - methods Plaque, Atherosclerotic - diagnostic imaging Tomography, Optical Coherence - methods |
| title | Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy |
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