Photoelectrochemical detection of alpha-fetoprotein based on ZnO inverse opals structure electrodes modified by Ag 2 S nanoparticles
In this work, a new photoelectrochemical biosensor based on Ag S nanoparticles (NPs) modified macroporous ZnO inverse opals structure (IOs) was developed for sensitive and rapid detection of alpha fetal protein (AFP). Small size and uniformly dispersed Ag S NPs were prepared using the Successive Ion...
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| Veröffentlicht in: | Scientific reports 2016-12, Vol.6, p.38400 |
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| creator | Jiang, Yandong Liu, Dali Yang, Yudan Xu, Ru Zhang, Tianxiang Sheng, Kuang Song, Hongwei |
| description | In this work, a new photoelectrochemical biosensor based on Ag
S nanoparticles (NPs) modified macroporous ZnO inverse opals structure (IOs) was developed for sensitive and rapid detection of alpha fetal protein (AFP). Small size and uniformly dispersed Ag
S NPs were prepared using the Successive Ionic Layer Adsorption And Reaction (SILAR) method, which were adsorbed on ZnO IOs surface and frame work as matrix for immobilization of AFP. The composite structure of ZnO/Ag
S expanded the scope of light absorption to long wavelength, which can make full use of the light energy. Meanwhile, an effective matching of energy levels between the conduction bands of Ag
S and ZnO are beneficial to the photo-generated electrons transfer. The biosensors based on FTO (fluorine-doped tinoxide) ZnO/Ag
S electrode showed enough sensitivity and a wide linear range from 0.05 ng/mL to 200 ng/mL with a low detection limit of 8 pg/mL for the detection of AFP. It also exhibited high reproducibility, specificity and stability. The proposed method was potentially attractive for achieving excellent photoelectrochemical biosensor for detection of other proteins. |
| doi_str_mv | 10.1038/srep38400 |
| format | Article |
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S nanoparticles (NPs) modified macroporous ZnO inverse opals structure (IOs) was developed for sensitive and rapid detection of alpha fetal protein (AFP). Small size and uniformly dispersed Ag
S NPs were prepared using the Successive Ionic Layer Adsorption And Reaction (SILAR) method, which were adsorbed on ZnO IOs surface and frame work as matrix for immobilization of AFP. The composite structure of ZnO/Ag
S expanded the scope of light absorption to long wavelength, which can make full use of the light energy. Meanwhile, an effective matching of energy levels between the conduction bands of Ag
S and ZnO are beneficial to the photo-generated electrons transfer. The biosensors based on FTO (fluorine-doped tinoxide) ZnO/Ag
S electrode showed enough sensitivity and a wide linear range from 0.05 ng/mL to 200 ng/mL with a low detection limit of 8 pg/mL for the detection of AFP. It also exhibited high reproducibility, specificity and stability. The proposed method was potentially attractive for achieving excellent photoelectrochemical biosensor for detection of other proteins.</description><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep38400</identifier><identifier>PMID: 27922086</identifier><language>eng</language><publisher>England</publisher><subject>alpha-Fetoproteins - analysis ; Antibodies, Monoclonal - chemistry ; Biosensing Techniques ; Electrochemical Techniques ; Electrodes ; Humans ; Limit of Detection ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - ultrastructure ; Reproducibility of Results ; Silver Compounds - chemistry ; Solutions ; Zinc Oxide - chemistry</subject><ispartof>Scientific reports, 2016-12, Vol.6, p.38400</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27922086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Yandong</creatorcontrib><creatorcontrib>Liu, Dali</creatorcontrib><creatorcontrib>Yang, Yudan</creatorcontrib><creatorcontrib>Xu, Ru</creatorcontrib><creatorcontrib>Zhang, Tianxiang</creatorcontrib><creatorcontrib>Sheng, Kuang</creatorcontrib><creatorcontrib>Song, Hongwei</creatorcontrib><title>Photoelectrochemical detection of alpha-fetoprotein based on ZnO inverse opals structure electrodes modified by Ag 2 S nanoparticles</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><description>In this work, a new photoelectrochemical biosensor based on Ag
S nanoparticles (NPs) modified macroporous ZnO inverse opals structure (IOs) was developed for sensitive and rapid detection of alpha fetal protein (AFP). Small size and uniformly dispersed Ag
S NPs were prepared using the Successive Ionic Layer Adsorption And Reaction (SILAR) method, which were adsorbed on ZnO IOs surface and frame work as matrix for immobilization of AFP. The composite structure of ZnO/Ag
S expanded the scope of light absorption to long wavelength, which can make full use of the light energy. Meanwhile, an effective matching of energy levels between the conduction bands of Ag
S and ZnO are beneficial to the photo-generated electrons transfer. The biosensors based on FTO (fluorine-doped tinoxide) ZnO/Ag
S electrode showed enough sensitivity and a wide linear range from 0.05 ng/mL to 200 ng/mL with a low detection limit of 8 pg/mL for the detection of AFP. It also exhibited high reproducibility, specificity and stability. The proposed method was potentially attractive for achieving excellent photoelectrochemical biosensor for detection of other proteins.</description><subject>alpha-Fetoproteins - analysis</subject><subject>Antibodies, Monoclonal - chemistry</subject><subject>Biosensing Techniques</subject><subject>Electrochemical Techniques</subject><subject>Electrodes</subject><subject>Humans</subject><subject>Limit of Detection</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - ultrastructure</subject><subject>Reproducibility of Results</subject><subject>Silver Compounds - chemistry</subject><subject>Solutions</subject><subject>Zinc Oxide - chemistry</subject><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1KAzEUhYMgttQufAHJC4zmb6bJshT_oFDBrtyUZHJjIzOTkKRC9z64AfUs7oVz-Q7cg9ANJXeUcHmfE0QuBSEXaM6IaBvGGZuhZc6fpKplSlB1hWZspRgjspuj79djKAEG6EsK_RFG3-sBWyjV8GHCwWE9xKNuHJQQUyjgJ2x0Bovr9X3aYT99QcqAQ9RDxrmkU19OCfBfpoWMx2C98xUxZ7z-wAy_4UlPFUjF9wPka3TpKgzLv71A-8eH_ea52e6eXjbrbRMVL41aGdM77qSFOgSYTkrHKRf1G6laI2nPjWuBtIJrSgjtNBVK2RacXvHO8AW6_Y2NJzOCPcTkR53Oh_82-A_lTGKT</recordid><startdate>20161206</startdate><enddate>20161206</enddate><creator>Jiang, Yandong</creator><creator>Liu, Dali</creator><creator>Yang, Yudan</creator><creator>Xu, Ru</creator><creator>Zhang, Tianxiang</creator><creator>Sheng, Kuang</creator><creator>Song, Hongwei</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20161206</creationdate><title>Photoelectrochemical detection of alpha-fetoprotein based on ZnO inverse opals structure electrodes modified by Ag 2 S nanoparticles</title><author>Jiang, Yandong ; Liu, Dali ; Yang, Yudan ; Xu, Ru ; Zhang, Tianxiang ; Sheng, Kuang ; Song, Hongwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p93t-97bbcf3f8de3f84eb688f3134279895b81c3bf5e0543a10016a1499d5efa736b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>alpha-Fetoproteins - analysis</topic><topic>Antibodies, Monoclonal - chemistry</topic><topic>Biosensing Techniques</topic><topic>Electrochemical Techniques</topic><topic>Electrodes</topic><topic>Humans</topic><topic>Limit of Detection</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metal Nanoparticles - ultrastructure</topic><topic>Reproducibility of Results</topic><topic>Silver Compounds - chemistry</topic><topic>Solutions</topic><topic>Zinc Oxide - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Yandong</creatorcontrib><creatorcontrib>Liu, Dali</creatorcontrib><creatorcontrib>Yang, Yudan</creatorcontrib><creatorcontrib>Xu, Ru</creatorcontrib><creatorcontrib>Zhang, Tianxiang</creatorcontrib><creatorcontrib>Sheng, Kuang</creatorcontrib><creatorcontrib>Song, Hongwei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Yandong</au><au>Liu, Dali</au><au>Yang, Yudan</au><au>Xu, Ru</au><au>Zhang, Tianxiang</au><au>Sheng, Kuang</au><au>Song, Hongwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photoelectrochemical detection of alpha-fetoprotein based on ZnO inverse opals structure electrodes modified by Ag 2 S nanoparticles</atitle><jtitle>Scientific reports</jtitle><addtitle>Sci Rep</addtitle><date>2016-12-06</date><risdate>2016</risdate><volume>6</volume><spage>38400</spage><pages>38400-</pages><eissn>2045-2322</eissn><abstract>In this work, a new photoelectrochemical biosensor based on Ag
S nanoparticles (NPs) modified macroporous ZnO inverse opals structure (IOs) was developed for sensitive and rapid detection of alpha fetal protein (AFP). Small size and uniformly dispersed Ag
S NPs were prepared using the Successive Ionic Layer Adsorption And Reaction (SILAR) method, which were adsorbed on ZnO IOs surface and frame work as matrix for immobilization of AFP. The composite structure of ZnO/Ag
S expanded the scope of light absorption to long wavelength, which can make full use of the light energy. Meanwhile, an effective matching of energy levels between the conduction bands of Ag
S and ZnO are beneficial to the photo-generated electrons transfer. The biosensors based on FTO (fluorine-doped tinoxide) ZnO/Ag
S electrode showed enough sensitivity and a wide linear range from 0.05 ng/mL to 200 ng/mL with a low detection limit of 8 pg/mL for the detection of AFP. It also exhibited high reproducibility, specificity and stability. The proposed method was potentially attractive for achieving excellent photoelectrochemical biosensor for detection of other proteins.</abstract><cop>England</cop><pmid>27922086</pmid><doi>10.1038/srep38400</doi></addata></record> |
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| source | MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; Springer Nature OA Free Journals |
| subjects | alpha-Fetoproteins - analysis Antibodies, Monoclonal - chemistry Biosensing Techniques Electrochemical Techniques Electrodes Humans Limit of Detection Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Reproducibility of Results Silver Compounds - chemistry Solutions Zinc Oxide - chemistry |
| title | Photoelectrochemical detection of alpha-fetoprotein based on ZnO inverse opals structure electrodes modified by Ag 2 S nanoparticles |
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