Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE 2 -dependent mechanism

Mesenchymal stem cells (MSCs) are speculated to act at macrophage-injury interfaces to mediate efficient repair. To explore this facet in-depth this study evaluates the influence of MSCs on human macrophages existing in distinct functional states. MSCs promoted macrophage differentiation, enhanced r...

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Veröffentlicht in:	Scientific reports 2016-12, Vol.6, p.38308
Hauptverfasser:	Vasandan, Anoop Babu, Jahnavi, Sowmya, Shashank, Chandanala, Prasad, Priya, Kumar, Anujith, Prasanna, S Jyothi
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Cell Communication Cell Differentiation - drug effects Coculture Techniques Culture Media, Conditioned - pharmacology Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Dinoprostone - metabolism Dinoprostone - pharmacology Gene Expression Regulation - drug effects Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Macrophage Activation - drug effects Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Phagocytosis - drug effects Primary Cell Culture RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Salmonella enterica - growth & development Signal Transduction Sirtuin 1 - genetics Sirtuin 1 - metabolism THP-1 Cells TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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