The 5-HT 1A/1B -receptor agonist eltoprazine increases both catecholamine release in the prefrontal cortex and dopamine release in the nucleus accumbens and decreases motivation for reward and "waiting" impulsivity, but increases "stopping" impulsivity

The 5-HT -receptor agonist eltoprazine has a behavioral drug signature that resembles that of a variety of psychostimulant drugs, despite the differences in receptor binding profile. These psychostimulants are effective in treating impulsivity disorders, most likely because they increase norepinephr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2017-01, Vol.794, p.257
Hauptverfasser:	Korte, S Mechiel, Prins, Jolanda, Van den Bergh, Filip S, Oosting, Ronald S, Dupree, Rudy, Korte-Bouws, Gerdien A H, Westphal, Koen G C, Olivier, Berend, Denys, Damiaan A, Garland, Alexis, Güntürkün, Onur
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Choice Behavior - drug effects Dopamine - secretion Impulsive Behavior - drug effects Male Motivation - drug effects Nucleus Accumbens - drug effects Nucleus Accumbens - secretion Piperazines - pharmacology Prefrontal Cortex - drug effects Prefrontal Cortex - secretion Rats Receptor, Serotonin, 5-HT1A - metabolism Receptor, Serotonin, 5-HT1B - metabolism Reward Serotonin 5-HT1 Receptor Agonists - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!