Toxins MazF and MqsR cleave Escherichia coli rRNA precursors at multiple sites

The endoribonuclease toxins of the E. coli toxin-antitoxin systems arrest bacterial growth and protein synthesis by targeting cellular mRNAs. As an exception, E. coli MazF was reported to cleave also 16S rRNA at a single site and separate an anti-Shine-Dalgarno sequence-containing RNA fragment from...

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Veröffentlicht in:	RNA biology 2017-01, Vol.14 (1), p.124-135
Hauptverfasser:	Mets, Toomas, Lippus, Markus, Schryer, David, Liiv, Aivar, Kasari, Villu, Paier, Anton, Maiväli, Ülo, Remme, Jaanus, Tenson, Tanel, Kaldalu, Niilo
Format:	Artikel
Sprache:	eng
Schlagworte:	bacteria bacterial growth Bacterial Toxins - metabolism Binding Sites Differential RNA sequencing DNA-Binding Proteins - metabolism Endoribonucleases - metabolism enzymes Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - metabolism MazF messenger RNA Models, Molecular MqsR Nucleic Acid Conformation Phosphorylation Protein Binding Protein Conformation protein subunits protein synthesis Research Paper ribosomal proteins ribosomal RNA ribosome ribosomes RNA Cleavage RNA precursors RNA Precursors - genetics RNA Precursors - metabolism RNA, Bacterial - chemistry RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Ribosomal - chemistry RNA, Ribosomal - genetics RNA, Ribosomal - metabolism rRNA precursors sequence analysis Sequence Analysis, RNA Stress, Physiological - genetics Toxin-Antitoxin systems toxins
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