Primary Role for Kinin B 1 and B 2 Receptors in Glioma Proliferation

This study investigated the role of kinins and their receptors in malignant brain tumors. As a first approach, GL-261 glioma cells were injected (2 × 10 cells in 2 μl/2 min) into the right striatum of adult C57/BL6 wild-type, kinin B and B receptor knockout (KOB R and KOB R) and B and B receptor dou...

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Veröffentlicht in:	Molecular neurobiology 2017-12, Vol.54 (10), p.7869
Hauptverfasser:	Nicoletti, Natália Fontana, Sénécal, Jacques, da Silva, Vinicius Duval, Roxo, Marcelo R, Ferreira, Nelson Pires, de Morais, Rafael Leite T, Pesquero, João Bosco, Campos, Maria Martha, Couture, Réjean, Morrone, Fernanda Bueno
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - pathology Bradykinin - analogs & derivatives Bradykinin - pharmacology Brain Neoplasms - drug therapy Brain Neoplasms - pathology Cell Proliferation - drug effects Dioxoles - pharmacology Glioma - drug therapy Glioma - pathology Mice Mice, Knockout Receptor, Bradykinin B1 - genetics Receptor, Bradykinin B1 - metabolism Receptor, Bradykinin B2 - genetics Receptor, Bradykinin B2 - metabolism Sulfonamides - pharmacology Up-Regulation - drug effects
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