Triggered activity in atrial myocytes is influenced by Na+ /Ca 2 + exchanger activity in genetically altered mice

Abstract Aims In atrial fibrillation (AF), increased function of the Na+ /Ca 2 + -exchanger (NCX) is one among several electrical remodeling mechanisms. Methods/results Using the patchclamp- and Ca 2 + imaging-methods, we investigated atrial myocytes from NCX-homozygous-overexpressor (OE)- and heter...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2016-12, Vol.101, p.106
Hauptverfasser:	Bögeholz, N., MD, Pauls, P., MSc, Kaese, S., MD, Schulte, J.S., MD, Lemoine, M.D., MD, Dechering, D.G., MD, Frommeyer, G., MD, Goldhaber, J.I., MD, Seidl, M.D., PhD, Kirchhefer, U., MD, Eckardt, L., MD, Müller, F.U., MD, Pott, C., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - genetics Animals Calcium - metabolism Calcium Signaling Cardiovascular Female Gene Expression Heart Atria - metabolism Male Membrane Potentials - genetics Mice Mice, Transgenic Myocardial Contraction - genetics Myocardium - metabolism Myocytes, Cardiac - metabolism Sarcoplasmic Reticulum - metabolism Sodium-Calcium Exchanger - genetics Sodium-Calcium Exchanger - metabolism
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