Mena INV dysregulates cortactin phosphorylation to promote invadopodium maturation

Invadopodia, actin-based protrusions of invasive carcinoma cells that focally activate extracellular matrix-degrading proteases, are essential for the migration and intravasation of tumor cells during dissemination from the primary tumor. We have previously shown that cortactin phosphorylation at ty...

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Veröffentlicht in:	Scientific reports 2016-11, Vol.6, p.36142
Hauptverfasser:	Weidmann, Maxwell D, Surve, Chinmay R, Eddy, Robert J, Chen, Xiaoming, Gertler, Frank B, Sharma, Ved P, Condeelis, John S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Movement Cortactin - genetics Cortactin - metabolism Female Humans Mice Microfilament Proteins - genetics Microfilament Proteins - metabolism Neoplasm Invasiveness Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Phosphorylation - genetics Podosomes - genetics Podosomes - metabolism Podosomes - pathology Protein Isoforms - genetics Protein Isoforms - metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism
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