Cholinergic PET imaging in infections and inflammation using 11 C-donepezil and 18 F-FEOBV

Immune cells utilize acetylcholine as a paracrine-signaling molecule. Many white blood cells express components of the cholinergic signaling pathway, and these are up-regulated when immune cells are activated. However, in vivo molecular imaging of cholinergic signaling in the context of inflammation...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2017-03, Vol.44 (3), p.449
Hauptverfasser:	Jørgensen, Nis Pedersen, Alstrup, Aage K O, Mortensen, Frank V, Knudsen, Karoline, Jakobsen, Steen, Madsen, Line Bille, Bender, Dirk, Breining, Peter, Petersen, Mikkel Steen, Schleimann, Mariane Høgsberg, Dagnæs-Hansen, Frederik, Gormsen, Lars C, Borghammer, Per
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Adult Aged Animals Carbon Radioisotopes Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Renal Cell - diagnostic imaging Cholinesterase Inhibitors - pharmacokinetics Female Fluorodeoxyglucose F18 Humans Indans - pharmacokinetics Kidney Neoplasms - diagnostic imaging Lung Neoplasms - diagnostic imaging Magnetic Resonance Imaging Male Mice Mice, Inbred C57BL Middle Aged Piperidines - pharmacokinetics Positron Emission Tomography Computed Tomography Radiopharmaceuticals - pharmacokinetics Staphylococcal Infections - diagnostic imaging Swine Vesicular Acetylcholine Transport Proteins - metabolism
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