Ran GTPase promotes cancer progression via Met recepto-rmediated downstream signaling

It has been shown previously that cancer cells with an activated oncogenic pathway, including Met activation, require Ran for growth and survival.Here, we show that knockdown of Ran leads to a reduction of Met receptor expression in several breast and lung cancer cell lines. This, in turn suppressed...

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Veröffentlicht in:	Oncotarget 2016-11, Vol.7 (46), p.75854
Hauptverfasser:	Yuen, Hiu-Fung, Chan, Ka-Kui, Platt-Higgins, Angela, Dakir, el-Habib, Matchett, Kyle B, Haggag, Yusuf Ahmed, Jithesh, Puthen V, Habib, Tanwir, Faheem, Ahmed, Dean, Fennell A, Morgan, Richard, Rudland, Philip S, El-Tanani, Mohamed
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Adhesion - drug effects Cell Adhesion - genetics Cell Line, Tumor Cell Movement - drug effects Cell Movement - genetics Cell Proliferation Disease Progression Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic - drug effects Gene Knockdown Techniques Hepatocyte Growth Factor - metabolism Humans Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Phosphorylation Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism ran GTP-Binding Protein - genetics ran GTP-Binding Protein - metabolism Signal Transduction - drug effects
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