Substitution dependent stereoselective construction of bicyclic lactones and its application to the total synthesis of pyranopyran, tetraketide and polyrhacitide A

A novel bicyclization strategy has been developed for the stereoselective synthesis of bicyclic lactones, i.e. 7-aryl or alkyl-2,6-dioxabicyclo[3.3.1]nonan-3-ones through a domino cyclization of ( R )-3-hydroxyhex-5-enoic acid with an aldehyde in the presence of 10 mol% trimethylsilyltriflate under...

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Veröffentlicht in:	Organic & biomolecular chemistry 2016-09, Vol.14 (37), p.8832-8837
Hauptverfasser:	Subba Reddy, B. V, Biradar, Dhanraj O, Vikram Reddy, Y, Yadav, J. S, Singarapu, Kiran Kumar, Sridhar, B
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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