Reversed Effects between Crude and Processed Ginger Extracts on PGF2α-Induced Contraction in Mouse Mesenteric Veins

Reversed Effects between Crude and Processed Ginger Extracts on PGF2α-Induced Contraction in Mouse Mesenteric Veins

The effects of crude and processed ginger extracts and pungent components, S-(+)-[6]-gingerol and [6]-shogaol, on noradrenaline (NA) and prostaglandin (PG) F2α-induced contraction were investigated using mouse mesenteric veins. Both spicy constituents inhibited the contractile responses to NA. Crude...

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Veröffentlicht in:Japanese journal of pharmacology 1989, Vol.50(2), pp.243-246
Hauptverfasser: PANCHO, Leonora Rivera, KIMURA, Ikuko, UNNO, Ryoichi, KURONO, Masayasu, KIMURA, Masayasu
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Cardiovascular system
Catechols - pharmacology
Dinoprost - pharmacology
Fatty Alcohols - pharmacology
In Vitro Techniques
Male
Medical sciences
Mesenteric Veins - drug effects
Mice
Miscellaneous
Muscle Contraction - drug effects
Muscle, Smooth, Vascular - drug effects
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Stereoisomerism
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Zusammenfassung:The effects of crude and processed ginger extracts and pungent components, S-(+)-[6]-gingerol and [6]-shogaol, on noradrenaline (NA) and prostaglandin (PG) F2α-induced contraction were investigated using mouse mesenteric veins. Both spicy constituents inhibited the contractile responses to NA. Crude ginger extract and S-(+)-[6]-gingerol potentiated the PGF2α-induced contraction, whereas processed ginger extract and [6]-shogaol inhibited the contraction.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.50.243