Aspergillosis and stem cell transplantation: An overview of experimental pathogenesis studies
Invasive aspergillosis is a life-threatening infection caused by the opportunistic filamentous fungus Aspergillus fumigatus. Patients undergoing haematopoietic stem cell transplant (HSCT) for the treatment of hematological malignancy are at particularly high risk of developing this fatal infection....
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| Veröffentlicht in: | Virulence 2016-11, Vol.7 (8), p.950-966 |
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| creator | Al-Bader, Nadia Sheppard, Donald C. |
| description | Invasive aspergillosis is a life-threatening infection caused by the opportunistic filamentous fungus Aspergillus fumigatus. Patients undergoing haematopoietic stem cell transplant (HSCT) for the treatment of hematological malignancy are at particularly high risk of developing this fatal infection. The susceptibility of HSCT patients to infection with A. fumigatus is a consequence of a complex interplay of both fungal and host factors. Here we review our understanding of the host-pathogen interactions underlying the susceptibility of the immunocompromised host to infection with A. fumigatus with a focus on the experimental validation of fungal and host factors relevant to HSCT patients. These include fungal factors such as secondary metabolites, cell wall constituents, and metabolic adaptations that facilitate immune evasion and survival within the host microenvironment, as well as the innate and adaptive immune responses involved in host defense against A. fumigatus. |
| doi_str_mv | 10.1080/21505594.2016.1231278 |
| format | Article |
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Patients undergoing haematopoietic stem cell transplant (HSCT) for the treatment of hematological malignancy are at particularly high risk of developing this fatal infection. The susceptibility of HSCT patients to infection with A. fumigatus is a consequence of a complex interplay of both fungal and host factors. Here we review our understanding of the host-pathogen interactions underlying the susceptibility of the immunocompromised host to infection with A. fumigatus with a focus on the experimental validation of fungal and host factors relevant to HSCT patients. 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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | aspergillosis aspergillus Aspergillus fumigatus - chemistry Aspergillus fumigatus - immunology Aspergillus fumigatus - pathogenicity Aspergillus fumigatus - physiology Hematologic Neoplasms - immunology Hematologic Neoplasms - microbiology Hematologic Neoplasms - therapy Host-Pathogen Interactions Humans Immune Evasion immunity Immunity, Innate Immunocompromised Host Invasive Pulmonary Aspergillosis - immunology Invasive Pulmonary Aspergillosis - microbiology Invasive Pulmonary Aspergillosis - physiopathology pathogenesis Review stem cell transplant Stem Cell Transplantation - adverse effects Virulence |
| title | Aspergillosis and stem cell transplantation: An overview of experimental pathogenesis studies |
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