Systemic onset juvenile idiopathic arthritis and exposure to fine particulate air pollution
Fine particulate matter (PM2.5) is a measurable component of ambient pollution, and positive associations of short-term PM2.5 exposure with the clinical presentation of systemic onset juvenile idiopathic arthritis (SJIA) in young children have been described in a regional cohort. Our objective was t...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2016-09, Vol.34 (5), p.946 |
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| creator | Zeft, Andrew S Prahalad, Sampath Schneider, Rayfel Dedeoglu, Fatma Weiss, Pamela F Grom, Alexei A Mix, Carter Pope Rd, C Arden |
| description | Fine particulate matter (PM2.5) is a measurable component of ambient pollution, and positive associations of short-term PM2.5 exposure with the clinical presentation of systemic onset juvenile idiopathic arthritis (SJIA) in young children have been described in a regional cohort. Our objective was to further establish associations between short-term pollution exposures and the reported clinical event of SJIA onset in cases residing from multiple metropolitan regions.
A case-crossover study design was used to analyse associations of short-term PM2.5 exposures with the event of SJIA symptom onset from cases residing in five metropolitan regions. Time trends, seasonality, month, and weekday were controlled for by matching. Selected exposure windows (to 14 days) of PM2.5 were examined.
Positive, statistically significant associations between PM2.5 concentrations and elevated risk of SJIA were not observed. The most positive associations of short-term PM2.5 exposure with SJIA were in children |
| format | Article |
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A case-crossover study design was used to analyse associations of short-term PM2.5 exposures with the event of SJIA symptom onset from cases residing in five metropolitan regions. Time trends, seasonality, month, and weekday were controlled for by matching. Selected exposure windows (to 14 days) of PM2.5 were examined.
Positive, statistically significant associations between PM2.5 concentrations and elevated risk of SJIA were not observed. The most positive associations of short-term PM2.5 exposure with SJIA were in children <5.5 years (RR 1.75, 95% CI 0.85-3.62). An ad hoc extended pooled analysis including previously reported cases from Utah's metropolitan areas identified an increased risk of SJIA for children <5.5 years (RR = 1.76, 95% CI 1.07-2.89 per 10 μg/m3 increase in 3-day lagged moving average PM2.5).
In this multi-city, multi-period study small, statistically insignificant PM2.5-SJIA associations are observed. However, as found in prior study, the PM2.5-SJIA association is most suggestive in preschool aged children. Larger numbers of SJIA cases spatially located in geographic areas which experience a greater day to day ambient particulate burden may be required by the analysis to demonstrate effects.</description><identifier>ISSN: 0392-856X</identifier><identifier>PMID: 27607024</identifier><language>eng</language><publisher>Italy</publisher><subject>Age Factors ; Air Pollutants - adverse effects ; Arthritis, Juvenile - chemically induced ; Arthritis, Juvenile - diagnosis ; Arthritis, Juvenile - epidemiology ; Child ; Child, Preschool ; Environmental Exposure - adverse effects ; Female ; Humans ; Male ; Ontario - epidemiology ; Particle Size ; Particulate Matter - adverse effects ; Risk Assessment ; Risk Factors ; Seasons ; Time Factors ; United States - epidemiology ; Urban Health</subject><ispartof>Clinical and experimental rheumatology, 2016-09, Vol.34 (5), p.946</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27607024$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeft, Andrew S</creatorcontrib><creatorcontrib>Prahalad, Sampath</creatorcontrib><creatorcontrib>Schneider, Rayfel</creatorcontrib><creatorcontrib>Dedeoglu, Fatma</creatorcontrib><creatorcontrib>Weiss, Pamela F</creatorcontrib><creatorcontrib>Grom, Alexei A</creatorcontrib><creatorcontrib>Mix, Carter</creatorcontrib><creatorcontrib>Pope Rd, C Arden</creatorcontrib><title>Systemic onset juvenile idiopathic arthritis and exposure to fine particulate air pollution</title><title>Clinical and experimental rheumatology</title><addtitle>Clin Exp Rheumatol</addtitle><description>Fine particulate matter (PM2.5) is a measurable component of ambient pollution, and positive associations of short-term PM2.5 exposure with the clinical presentation of systemic onset juvenile idiopathic arthritis (SJIA) in young children have been described in a regional cohort. Our objective was to further establish associations between short-term pollution exposures and the reported clinical event of SJIA onset in cases residing from multiple metropolitan regions.
A case-crossover study design was used to analyse associations of short-term PM2.5 exposures with the event of SJIA symptom onset from cases residing in five metropolitan regions. Time trends, seasonality, month, and weekday were controlled for by matching. Selected exposure windows (to 14 days) of PM2.5 were examined.
Positive, statistically significant associations between PM2.5 concentrations and elevated risk of SJIA were not observed. The most positive associations of short-term PM2.5 exposure with SJIA were in children <5.5 years (RR 1.75, 95% CI 0.85-3.62). An ad hoc extended pooled analysis including previously reported cases from Utah's metropolitan areas identified an increased risk of SJIA for children <5.5 years (RR = 1.76, 95% CI 1.07-2.89 per 10 μg/m3 increase in 3-day lagged moving average PM2.5).
In this multi-city, multi-period study small, statistically insignificant PM2.5-SJIA associations are observed. However, as found in prior study, the PM2.5-SJIA association is most suggestive in preschool aged children. Larger numbers of SJIA cases spatially located in geographic areas which experience a greater day to day ambient particulate burden may be required by the analysis to demonstrate effects.</description><subject>Age Factors</subject><subject>Air Pollutants - adverse effects</subject><subject>Arthritis, Juvenile - chemically induced</subject><subject>Arthritis, Juvenile - diagnosis</subject><subject>Arthritis, Juvenile - epidemiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Environmental Exposure - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Ontario - epidemiology</subject><subject>Particle Size</subject><subject>Particulate Matter - adverse effects</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Seasons</subject><subject>Time Factors</subject><subject>United States - epidemiology</subject><subject>Urban Health</subject><issn>0392-856X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j8tKxDAYRrNQnHH0FSQvUEhzbZcyeIOBWagguBjS9A_zD20TklSct7egrs7iHD74LsiaiZZXjdIfK3Kd84kxrpU2V2TFjWaGcbkmn6_nXGBER8OUodDT_AUTDkCxxxBtOS7GpnJMWDBTO_UUvmPIcwJaAvU4AY2LRzcPtgC1mGgMwzAXDNMNufR2yHD7xw15f3x42z5Xu_3Ty_Z-V8XaNKUSyvC28aA6baTzfaecbITkTKvGK-gU1NJ4B1CDk0IsCWjuobaidabXSmzI3e9unLsR-kNMONp0Pvy_FD-seFAO</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Zeft, Andrew S</creator><creator>Prahalad, Sampath</creator><creator>Schneider, Rayfel</creator><creator>Dedeoglu, Fatma</creator><creator>Weiss, Pamela F</creator><creator>Grom, Alexei A</creator><creator>Mix, Carter</creator><creator>Pope Rd, C Arden</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20160901</creationdate><title>Systemic onset juvenile idiopathic arthritis and exposure to fine particulate air pollution</title><author>Zeft, Andrew S ; Prahalad, Sampath ; Schneider, Rayfel ; Dedeoglu, Fatma ; Weiss, Pamela F ; Grom, Alexei A ; Mix, Carter ; Pope Rd, C Arden</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p178t-357298fe5b674cfdb5c483420658f5eb5e147fcee1ec4334cfe62fe1a39c7d653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age Factors</topic><topic>Air Pollutants - adverse effects</topic><topic>Arthritis, Juvenile - chemically induced</topic><topic>Arthritis, Juvenile - diagnosis</topic><topic>Arthritis, Juvenile - epidemiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Environmental Exposure - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Ontario - epidemiology</topic><topic>Particle Size</topic><topic>Particulate Matter - adverse effects</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Seasons</topic><topic>Time Factors</topic><topic>United States - epidemiology</topic><topic>Urban Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeft, Andrew S</creatorcontrib><creatorcontrib>Prahalad, Sampath</creatorcontrib><creatorcontrib>Schneider, Rayfel</creatorcontrib><creatorcontrib>Dedeoglu, Fatma</creatorcontrib><creatorcontrib>Weiss, Pamela F</creatorcontrib><creatorcontrib>Grom, Alexei A</creatorcontrib><creatorcontrib>Mix, Carter</creatorcontrib><creatorcontrib>Pope Rd, C Arden</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeft, Andrew S</au><au>Prahalad, Sampath</au><au>Schneider, Rayfel</au><au>Dedeoglu, Fatma</au><au>Weiss, Pamela F</au><au>Grom, Alexei A</au><au>Mix, Carter</au><au>Pope Rd, C Arden</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic onset juvenile idiopathic arthritis and exposure to fine particulate air pollution</atitle><jtitle>Clinical and experimental rheumatology</jtitle><addtitle>Clin Exp Rheumatol</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>34</volume><issue>5</issue><spage>946</spage><pages>946-</pages><issn>0392-856X</issn><abstract>Fine particulate matter (PM2.5) is a measurable component of ambient pollution, and positive associations of short-term PM2.5 exposure with the clinical presentation of systemic onset juvenile idiopathic arthritis (SJIA) in young children have been described in a regional cohort. Our objective was to further establish associations between short-term pollution exposures and the reported clinical event of SJIA onset in cases residing from multiple metropolitan regions.
A case-crossover study design was used to analyse associations of short-term PM2.5 exposures with the event of SJIA symptom onset from cases residing in five metropolitan regions. Time trends, seasonality, month, and weekday were controlled for by matching. Selected exposure windows (to 14 days) of PM2.5 were examined.
Positive, statistically significant associations between PM2.5 concentrations and elevated risk of SJIA were not observed. The most positive associations of short-term PM2.5 exposure with SJIA were in children <5.5 years (RR 1.75, 95% CI 0.85-3.62). An ad hoc extended pooled analysis including previously reported cases from Utah's metropolitan areas identified an increased risk of SJIA for children <5.5 years (RR = 1.76, 95% CI 1.07-2.89 per 10 μg/m3 increase in 3-day lagged moving average PM2.5).
In this multi-city, multi-period study small, statistically insignificant PM2.5-SJIA associations are observed. However, as found in prior study, the PM2.5-SJIA association is most suggestive in preschool aged children. Larger numbers of SJIA cases spatially located in geographic areas which experience a greater day to day ambient particulate burden may be required by the analysis to demonstrate effects.</abstract><cop>Italy</cop><pmid>27607024</pmid></addata></record> |
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| identifier | ISSN: 0392-856X |
| ispartof | Clinical and experimental rheumatology, 2016-09, Vol.34 (5), p.946 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Age Factors Air Pollutants - adverse effects Arthritis, Juvenile - chemically induced Arthritis, Juvenile - diagnosis Arthritis, Juvenile - epidemiology Child Child, Preschool Environmental Exposure - adverse effects Female Humans Male Ontario - epidemiology Particle Size Particulate Matter - adverse effects Risk Assessment Risk Factors Seasons Time Factors United States - epidemiology Urban Health |
| title | Systemic onset juvenile idiopathic arthritis and exposure to fine particulate air pollution |
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