An essential role for the IL-2 receptor in T reg cell function

Regulatory T cells (T cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for a simple network based on the consumption of IL-2 by T cells in their suppressor function. However, congenital...

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Veröffentlicht in:	Nature immunology 2016-11, Vol.17 (11), p.1322
Hauptverfasser:	Chinen, Takatoshi, Kannan, Arun K, Levine, Andrew G, Fan, Xiying, Klein, Ulf, Zheng, Ye, Gasteiger, Georg, Feng, Yongqiang, Fontenot, Jason D, Rudensky, Alexander Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cytokines - metabolism Female Immunomodulation Male Mice Mice, Knockout Mice, Transgenic Phenotype Receptors, Interleukin-2 - metabolism STAT5 Transcription Factor - genetics STAT5 Transcription Factor - metabolism T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism
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