Primary tumor SUV max on preoperative FDG-PET/CT is a prognostic indicator in stage IA2-IIB cervical cancer patients treated with radical hysterectomy
The objective of the present study was to investigate the prognostic value of F-fluoro-2-deoxy-D-glucose (FDG) uptake by primary tumors on positron emission tomography/computed tomography (PET/CT) in surgically resectable cervical cancer. A total of 59 patients with stage IA2-IIB cervical cancer who...
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| Veröffentlicht in: | Molecular and clinical oncology 2016-09, Vol.5 (3), p.216 |
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| container_title | Molecular and clinical oncology |
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| creator | Yagi, Shigetaka Yahata, Tamaki Mabuchi, Yasushi Tanizaki, Yuko Kobayashi, Aya Shiro, Michihisa Ota, Nami Minami, Sawako Terada, Masaki Ino, Kazuhiko |
| description | The objective of the present study was to investigate the prognostic value of
F-fluoro-2-deoxy-D-glucose (FDG) uptake by primary tumors on positron emission tomography/computed tomography (PET/CT) in surgically resectable cervical cancer. A total of 59 patients with stage IA2-IIB cervical cancer who underwent preoperative FDG-PET/CT, followed by radical hysterectomy and lymphadenectomy, were included in the study. The maximum standardized uptake value (SUV
) of the primary tumor was measured, and the association between the SUV
and clinicopathological factors or patient outcomes was analyzed. The SUV
was significantly higher in patients with an advanced stage, lymph node metastasis, lymph-vascular space involvement and large tumors. The overall survival (OS) and progression-free survival (PFS) of patients with a high SUV
were significantly lower compared with patients with a low SUV
, using an optimal cut-off value of 7.36 for OS and 5.59 for PFS obtained from receiver operating characteristic curve analysis. Similarly, OS and PFS in patients with a high SUV
were significantly lower in 39 patients with stage IB using a cut-off value of 7.90 and 6.69 for OS and PFS, respectively. Finally, multivariate analyses showed that the SUV
of the primary tumor was an independent prognostic factor for impaired PFS in all patients and those with stage IB alone. These findings demonstrated that a high SUV
on preoperative PET/CT was correlated with unfavorable clinical outcomes in patients receiving radical hysterectomy, suggesting that the SUV
of the primary tumor may be a prognostic indicator for surgically-treated, early-stage invasive cervical cancer. |
| format | Article |
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F-fluoro-2-deoxy-D-glucose (FDG) uptake by primary tumors on positron emission tomography/computed tomography (PET/CT) in surgically resectable cervical cancer. A total of 59 patients with stage IA2-IIB cervical cancer who underwent preoperative FDG-PET/CT, followed by radical hysterectomy and lymphadenectomy, were included in the study. The maximum standardized uptake value (SUV
) of the primary tumor was measured, and the association between the SUV
and clinicopathological factors or patient outcomes was analyzed. The SUV
was significantly higher in patients with an advanced stage, lymph node metastasis, lymph-vascular space involvement and large tumors. The overall survival (OS) and progression-free survival (PFS) of patients with a high SUV
were significantly lower compared with patients with a low SUV
, using an optimal cut-off value of 7.36 for OS and 5.59 for PFS obtained from receiver operating characteristic curve analysis. Similarly, OS and PFS in patients with a high SUV
were significantly lower in 39 patients with stage IB using a cut-off value of 7.90 and 6.69 for OS and PFS, respectively. Finally, multivariate analyses showed that the SUV
of the primary tumor was an independent prognostic factor for impaired PFS in all patients and those with stage IB alone. These findings demonstrated that a high SUV
on preoperative PET/CT was correlated with unfavorable clinical outcomes in patients receiving radical hysterectomy, suggesting that the SUV
of the primary tumor may be a prognostic indicator for surgically-treated, early-stage invasive cervical cancer.</description><identifier>ISSN: 2049-9450</identifier><identifier>PMID: 27588184</identifier><language>eng</language><publisher>England</publisher><ispartof>Molecular and clinical oncology, 2016-09, Vol.5 (3), p.216</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27588184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yagi, Shigetaka</creatorcontrib><creatorcontrib>Yahata, Tamaki</creatorcontrib><creatorcontrib>Mabuchi, Yasushi</creatorcontrib><creatorcontrib>Tanizaki, Yuko</creatorcontrib><creatorcontrib>Kobayashi, Aya</creatorcontrib><creatorcontrib>Shiro, Michihisa</creatorcontrib><creatorcontrib>Ota, Nami</creatorcontrib><creatorcontrib>Minami, Sawako</creatorcontrib><creatorcontrib>Terada, Masaki</creatorcontrib><creatorcontrib>Ino, Kazuhiko</creatorcontrib><title>Primary tumor SUV max on preoperative FDG-PET/CT is a prognostic indicator in stage IA2-IIB cervical cancer patients treated with radical hysterectomy</title><title>Molecular and clinical oncology</title><addtitle>Mol Clin Oncol</addtitle><description>The objective of the present study was to investigate the prognostic value of
F-fluoro-2-deoxy-D-glucose (FDG) uptake by primary tumors on positron emission tomography/computed tomography (PET/CT) in surgically resectable cervical cancer. A total of 59 patients with stage IA2-IIB cervical cancer who underwent preoperative FDG-PET/CT, followed by radical hysterectomy and lymphadenectomy, were included in the study. The maximum standardized uptake value (SUV
) of the primary tumor was measured, and the association between the SUV
and clinicopathological factors or patient outcomes was analyzed. The SUV
was significantly higher in patients with an advanced stage, lymph node metastasis, lymph-vascular space involvement and large tumors. The overall survival (OS) and progression-free survival (PFS) of patients with a high SUV
were significantly lower compared with patients with a low SUV
, using an optimal cut-off value of 7.36 for OS and 5.59 for PFS obtained from receiver operating characteristic curve analysis. Similarly, OS and PFS in patients with a high SUV
were significantly lower in 39 patients with stage IB using a cut-off value of 7.90 and 6.69 for OS and PFS, respectively. Finally, multivariate analyses showed that the SUV
of the primary tumor was an independent prognostic factor for impaired PFS in all patients and those with stage IB alone. These findings demonstrated that a high SUV
on preoperative PET/CT was correlated with unfavorable clinical outcomes in patients receiving radical hysterectomy, suggesting that the SUV
of the primary tumor may be a prognostic indicator for surgically-treated, early-stage invasive cervical cancer.</description><issn>2049-9450</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFj01Ow0AMhWcBohXtFZAvEBHSRE2WUFrIrhKBbWUmph3U-ZHHLeQinJcRhTVv4ye9z5bfmRoXedlkTVnlIzWN8T1PauZ5UTUXalTMq7q-qcux-lqzscgDyMF6hqfnF7D4Cd5BYPKBGMUcCVb3D9l62V0vOjARMIV-63wUo8G43miUtGwcRMEtQXtbZG17B5r4mLI9aHTJQ0jHyEkEYUKhHj6M7ICx_4F2QxRi0uLtMFHnb7iPNP2dl-pqtewWj1k4vFrqN-H09eavyOxf4BtKC1W4</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Yagi, Shigetaka</creator><creator>Yahata, Tamaki</creator><creator>Mabuchi, Yasushi</creator><creator>Tanizaki, Yuko</creator><creator>Kobayashi, Aya</creator><creator>Shiro, Michihisa</creator><creator>Ota, Nami</creator><creator>Minami, Sawako</creator><creator>Terada, Masaki</creator><creator>Ino, Kazuhiko</creator><scope>NPM</scope></search><sort><creationdate>201609</creationdate><title>Primary tumor SUV max on preoperative FDG-PET/CT is a prognostic indicator in stage IA2-IIB cervical cancer patients treated with radical hysterectomy</title><author>Yagi, Shigetaka ; Yahata, Tamaki ; Mabuchi, Yasushi ; Tanizaki, Yuko ; Kobayashi, Aya ; Shiro, Michihisa ; Ota, Nami ; Minami, Sawako ; Terada, Masaki ; Ino, Kazuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_275881843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Yagi, Shigetaka</creatorcontrib><creatorcontrib>Yahata, Tamaki</creatorcontrib><creatorcontrib>Mabuchi, Yasushi</creatorcontrib><creatorcontrib>Tanizaki, Yuko</creatorcontrib><creatorcontrib>Kobayashi, Aya</creatorcontrib><creatorcontrib>Shiro, Michihisa</creatorcontrib><creatorcontrib>Ota, Nami</creatorcontrib><creatorcontrib>Minami, Sawako</creatorcontrib><creatorcontrib>Terada, Masaki</creatorcontrib><creatorcontrib>Ino, Kazuhiko</creatorcontrib><collection>PubMed</collection><jtitle>Molecular and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yagi, Shigetaka</au><au>Yahata, Tamaki</au><au>Mabuchi, Yasushi</au><au>Tanizaki, Yuko</au><au>Kobayashi, Aya</au><au>Shiro, Michihisa</au><au>Ota, Nami</au><au>Minami, Sawako</au><au>Terada, Masaki</au><au>Ino, Kazuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary tumor SUV max on preoperative FDG-PET/CT is a prognostic indicator in stage IA2-IIB cervical cancer patients treated with radical hysterectomy</atitle><jtitle>Molecular and clinical oncology</jtitle><addtitle>Mol Clin Oncol</addtitle><date>2016-09</date><risdate>2016</risdate><volume>5</volume><issue>3</issue><spage>216</spage><pages>216-</pages><issn>2049-9450</issn><abstract>The objective of the present study was to investigate the prognostic value of
F-fluoro-2-deoxy-D-glucose (FDG) uptake by primary tumors on positron emission tomography/computed tomography (PET/CT) in surgically resectable cervical cancer. A total of 59 patients with stage IA2-IIB cervical cancer who underwent preoperative FDG-PET/CT, followed by radical hysterectomy and lymphadenectomy, were included in the study. The maximum standardized uptake value (SUV
) of the primary tumor was measured, and the association between the SUV
and clinicopathological factors or patient outcomes was analyzed. The SUV
was significantly higher in patients with an advanced stage, lymph node metastasis, lymph-vascular space involvement and large tumors. The overall survival (OS) and progression-free survival (PFS) of patients with a high SUV
were significantly lower compared with patients with a low SUV
, using an optimal cut-off value of 7.36 for OS and 5.59 for PFS obtained from receiver operating characteristic curve analysis. Similarly, OS and PFS in patients with a high SUV
were significantly lower in 39 patients with stage IB using a cut-off value of 7.90 and 6.69 for OS and PFS, respectively. Finally, multivariate analyses showed that the SUV
of the primary tumor was an independent prognostic factor for impaired PFS in all patients and those with stage IB alone. These findings demonstrated that a high SUV
on preoperative PET/CT was correlated with unfavorable clinical outcomes in patients receiving radical hysterectomy, suggesting that the SUV
of the primary tumor may be a prognostic indicator for surgically-treated, early-stage invasive cervical cancer.</abstract><cop>England</cop><pmid>27588184</pmid></addata></record> |
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| ispartof | Molecular and clinical oncology, 2016-09, Vol.5 (3), p.216 |
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| language | eng |
| recordid | cdi_pubmed_primary_27588184 |
| source | Spandidos Publications Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| title | Primary tumor SUV max on preoperative FDG-PET/CT is a prognostic indicator in stage IA2-IIB cervical cancer patients treated with radical hysterectomy |
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