Steroid Hormones Mediate Reversible Phenotypic Transition between Transformed and Untransformed States in Mouse Fibroblasts

Hydrocortisone at physiological concentrations reversibly inhibits DNA synthesis in ST1 cells (a line of mouse fibroblasts possessing 40 chromosomes and derived from Swiss 3T3 cells). This inhibitory activity is a property of glucocorticoids, but the β -OH of C-11 of glucocorticoids is not essential...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1978-06, Vol.75 (6), p.2805-2809
Hauptverfasser:	Mari C. S. Armelin, Armelin, Hugo A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 cells Albumins Animals Cell culture techniques Cell Division - drug effects Cell growth Cell Line Cell Transformation, Neoplastic - drug effects Cells Contact Inhibition - drug effects Culture Media DNA - biosynthesis Fibrosarcoma - pathology Hormones Hydrocortisone - pharmacology Insulin Insulin - pharmacology Mice Mice, Nude Sarcoma, Experimental - pathology Serum Albumin, Bovine - pharmacology Steroids Swiss 3T3 cells Tumors
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