Synthesis of novel C 2 -symmetric testosterone dimers and evaluation of antiproliferative activity on androgen-dependent and -independent prostate cancer cell lines

A series of 7α-linked testosterone dimers were made and tested for biological activity on both androgen-dependent (LNCaP) and androgen-independent (DU-145 and PC3) prostate cancer cell lines. The synthesis proceeds through the formation of a trans-4-(17β-acetoxy-4-androsten-3-one-7α-yl)-but-2-enoic...

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Veröffentlicht in:	Steroids 2016-11, Vol.115, p.98
Hauptverfasser:	Vesper, Anne-Rose, Lacroix, Jacques, C-Gaudreault, René, Tajmir-Rihai, Heidar-Ali, Bérubé, Gervais
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens - metabolism Cell Line, Tumor Cell Proliferation - drug effects Humans Magnetic Resonance Spectroscopy Male Molecular Structure Prostatic Neoplasms - metabolism Testosterone - chemistry Testosterone - pharmacology
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