Mycobacterial carbonic anhydrase inhibition with phenolic acids and esters: kinetic and computational investigations

A series of phenolic acids and some of their esters, derivatives of caffeic, ferulic, and p -coumaric acid, was investigated for the inhibition of three -carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic bacterium Mycobacterium tuberculosis , Rv1248, Rv3588 and Rv3273 -CAs. Some of these com...

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Veröffentlicht in:	Organic & biomolecular chemistry 2016-09, Vol.14 (35), p.8322-833
Hauptverfasser:	Cau, Ylenia, Mori, Mattia, Supuran, Claudiu T, Botta, Maurizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial Proteins - chemistry Caffeic Acids - chemistry Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrases - chemistry Catalytic Domain Coumaric Acids - chemistry Esters - chemistry Humans Kinetics Models, Molecular Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Propionates - chemistry Protein Binding Protein Conformation Structure-Activity Relationship Zinc - chemistry
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