Predictive Factors for Excellent or Extremely Poor Functional Outcome in Initial Atrial Fibrillation-Related Cardioembolic Stroke
Background: We aimed to determine the predictive factors for excellent or extremely poor functional outcome in patients with first-ever atrial fibrillation (AF)-related cardioembolic stroke. Methods: Retrospective observational study from a database. Patients with AF-related cardioembolic stroke wit...
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| Veröffentlicht in: | European neurology 2016-01, Vol.76 (3-4), p.105-111 |
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| creator | Tanaka, Koji Yamada, Takeshi Torii, Takako Matsumoto, Shoji Yoshimura, Takeo Takase, Kei-ichiro Wakata, Yoshifumi Nakashima, Naoki Kira, Jun-ichi Murai, Hiroyuki |
| description | Background: We aimed to determine the predictive factors for excellent or extremely poor functional outcome in patients with first-ever atrial fibrillation (AF)-related cardioembolic stroke. Methods: Retrospective observational study from a database. Patients with AF-related cardioembolic stroke with a premorbid modified Rankin Scale (mRS) score of 0 or 1 and without a previous history of stroke were included. Results: Factors associated with excellent functional outcome (mRS scores of 0 or 1; n = 77; 30.4% of patients) included age >78 years (OR 0.31, 95% CI 0.15-0.61), male sex (OR 2.16, 95% CI 1.04-4.60), absence of hypertension (OR 0.46, 95% CI 0.22-0.94) and initial National Institutes of Health Stroke Scale (NIHSS) score of >9 (OR 0.08, 95% CI 0.03-0.16). Factors associated with extremely poor functional outcome (mRS scores of 5 or 6; n = 63; 24.9%) included age >78 years (OR 3.30, 95% CI 1.54-7.39), initial NIHSS score of >9 (OR 12.38, 95% CI 5.40-32.56), congestive heart failure (OR 4.82, 95% CI 2.00-12.19) and ischemic heart disease (OR 4.02, 95% CI 1.18-14.69). Conclusions: Predictive factors exist to delineate excellent and extremely poor functional outcomes after a first-time stroke associated with AF. |
| doi_str_mv | 10.1159/000447629 |
| format | Article |
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Methods: Retrospective observational study from a database. Patients with AF-related cardioembolic stroke with a premorbid modified Rankin Scale (mRS) score of 0 or 1 and without a previous history of stroke were included. Results: Factors associated with excellent functional outcome (mRS scores of 0 or 1; n = 77; 30.4% of patients) included age >78 years (OR 0.31, 95% CI 0.15-0.61), male sex (OR 2.16, 95% CI 1.04-4.60), absence of hypertension (OR 0.46, 95% CI 0.22-0.94) and initial National Institutes of Health Stroke Scale (NIHSS) score of >9 (OR 0.08, 95% CI 0.03-0.16). Factors associated with extremely poor functional outcome (mRS scores of 5 or 6; n = 63; 24.9%) included age >78 years (OR 3.30, 95% CI 1.54-7.39), initial NIHSS score of >9 (OR 12.38, 95% CI 5.40-32.56), congestive heart failure (OR 4.82, 95% CI 2.00-12.19) and ischemic heart disease (OR 4.02, 95% CI 1.18-14.69). Conclusions: Predictive factors exist to delineate excellent and extremely poor functional outcomes after a first-time stroke associated with AF.</description><identifier>ISSN: 0014-3022</identifier><identifier>EISSN: 1421-9913</identifier><identifier>DOI: 10.1159/000447629</identifier><identifier>PMID: 27508927</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Activities of Daily Living - classification ; Aged ; Aged, 80 and over ; Atrial Fibrillation - complications ; Atrial Fibrillation - therapy ; Diagnostic Imaging ; Disability Evaluation ; Female ; Humans ; Hypertension - complications ; Intracranial Embolism - classification ; Intracranial Embolism - diagnosis ; Intracranial Embolism - etiology ; Intracranial Embolism - therapy ; Ischemic Attack, Transient - classification ; Ischemic Attack, Transient - diagnosis ; Ischemic Attack, Transient - etiology ; Ischemic Attack, Transient - therapy ; Male ; Middle Aged ; Neurologic Examination ; Original Paper ; Outcome Assessment (Health Care) ; Prognosis ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Stroke - classification ; Stroke - complications ; Stroke - diagnosis ; Stroke - etiology ; Stroke - therapy</subject><ispartof>European neurology, 2016-01, Vol.76 (3-4), p.105-111</ispartof><rights>2016 S. Karger AG, Basel</rights><rights>2016 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27508927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Koji</creatorcontrib><creatorcontrib>Yamada, Takeshi</creatorcontrib><creatorcontrib>Torii, Takako</creatorcontrib><creatorcontrib>Matsumoto, Shoji</creatorcontrib><creatorcontrib>Yoshimura, Takeo</creatorcontrib><creatorcontrib>Takase, Kei-ichiro</creatorcontrib><creatorcontrib>Wakata, Yoshifumi</creatorcontrib><creatorcontrib>Nakashima, Naoki</creatorcontrib><creatorcontrib>Kira, Jun-ichi</creatorcontrib><creatorcontrib>Murai, Hiroyuki</creatorcontrib><title>Predictive Factors for Excellent or Extremely Poor Functional Outcome in Initial Atrial Fibrillation-Related Cardioembolic Stroke</title><title>European neurology</title><addtitle>Eur Neurol</addtitle><description>Background: We aimed to determine the predictive factors for excellent or extremely poor functional outcome in patients with first-ever atrial fibrillation (AF)-related cardioembolic stroke. Methods: Retrospective observational study from a database. Patients with AF-related cardioembolic stroke with a premorbid modified Rankin Scale (mRS) score of 0 or 1 and without a previous history of stroke were included. Results: Factors associated with excellent functional outcome (mRS scores of 0 or 1; n = 77; 30.4% of patients) included age >78 years (OR 0.31, 95% CI 0.15-0.61), male sex (OR 2.16, 95% CI 1.04-4.60), absence of hypertension (OR 0.46, 95% CI 0.22-0.94) and initial National Institutes of Health Stroke Scale (NIHSS) score of >9 (OR 0.08, 95% CI 0.03-0.16). Factors associated with extremely poor functional outcome (mRS scores of 5 or 6; n = 63; 24.9%) included age >78 years (OR 3.30, 95% CI 1.54-7.39), initial NIHSS score of >9 (OR 12.38, 95% CI 5.40-32.56), congestive heart failure (OR 4.82, 95% CI 2.00-12.19) and ischemic heart disease (OR 4.02, 95% CI 1.18-14.69). Conclusions: Predictive factors exist to delineate excellent and extremely poor functional outcomes after a first-time stroke associated with AF.</description><subject>Activities of Daily Living - classification</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - therapy</subject><subject>Diagnostic Imaging</subject><subject>Disability Evaluation</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Intracranial Embolism - classification</subject><subject>Intracranial Embolism - diagnosis</subject><subject>Intracranial Embolism - etiology</subject><subject>Intracranial Embolism - therapy</subject><subject>Ischemic Attack, Transient - classification</subject><subject>Ischemic Attack, Transient - diagnosis</subject><subject>Ischemic Attack, Transient - etiology</subject><subject>Ischemic Attack, Transient - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurologic Examination</subject><subject>Original Paper</subject><subject>Outcome Assessment (Health Care)</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stroke - classification</subject><subject>Stroke - complications</subject><subject>Stroke - diagnosis</subject><subject>Stroke - etiology</subject><subject>Stroke - therapy</subject><issn>0014-3022</issn><issn>1421-9913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kL1PwzAQxS0EoqUwsCPkEYaA7dhJPKKKAhJSKz7myHYuyDSJwXYQHfnPSWnp9O6dfu-kewidUnJFqZDXhBDO84zJPTSmnNFESpruozEhlCcpYWyEjkJ4H6yQeXGIRiwXpJAsH6OfhYfKmmi_AM-Uic4HXDuPb78NNA10Ef-Z6KGFZoUXbrCzvhsCrlMNnvfRuBaw7fBDZ6MdVjfRr2VmtbdNo9Zg8gTDABWeKl9ZB612jTX4OXq3hGN0UKsmwMlWJ-h1dvsyvU8e53cP05vHxLAsiwlkOQWeEwMcdFGLnKSVzozMhFCpZDVornSRUSUpSKUJk6QigmmtaF1XKU8n6GJz98O7zx5CLFsb1k-qDlwfSlqkghe5yNIBvdygxrsQPNTlh7et8quSknLdeLlrfGDPt2d73UK1I_8rHoCzDbBU_g38DtjmfwEVYYZ0</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Tanaka, Koji</creator><creator>Yamada, Takeshi</creator><creator>Torii, Takako</creator><creator>Matsumoto, Shoji</creator><creator>Yoshimura, Takeo</creator><creator>Takase, Kei-ichiro</creator><creator>Wakata, Yoshifumi</creator><creator>Nakashima, Naoki</creator><creator>Kira, Jun-ichi</creator><creator>Murai, Hiroyuki</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160101</creationdate><title>Predictive Factors for Excellent or Extremely Poor Functional Outcome in Initial Atrial Fibrillation-Related Cardioembolic Stroke</title><author>Tanaka, Koji ; Yamada, Takeshi ; Torii, Takako ; Matsumoto, Shoji ; Yoshimura, Takeo ; Takase, Kei-ichiro ; Wakata, Yoshifumi ; Nakashima, Naoki ; Kira, Jun-ichi ; Murai, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c266t-e671e470ce4eb8f5703db6c9655a392feb4ab861a91e9ab0290d052bba1ffd343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Activities of Daily Living - classification</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - therapy</topic><topic>Diagnostic Imaging</topic><topic>Disability Evaluation</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Intracranial Embolism - classification</topic><topic>Intracranial Embolism - diagnosis</topic><topic>Intracranial Embolism - etiology</topic><topic>Intracranial Embolism - therapy</topic><topic>Ischemic Attack, Transient - classification</topic><topic>Ischemic Attack, Transient - diagnosis</topic><topic>Ischemic Attack, Transient - etiology</topic><topic>Ischemic Attack, Transient - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurologic Examination</topic><topic>Original Paper</topic><topic>Outcome Assessment (Health Care)</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Stroke - classification</topic><topic>Stroke - complications</topic><topic>Stroke - diagnosis</topic><topic>Stroke - etiology</topic><topic>Stroke - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Koji</creatorcontrib><creatorcontrib>Yamada, Takeshi</creatorcontrib><creatorcontrib>Torii, Takako</creatorcontrib><creatorcontrib>Matsumoto, Shoji</creatorcontrib><creatorcontrib>Yoshimura, Takeo</creatorcontrib><creatorcontrib>Takase, Kei-ichiro</creatorcontrib><creatorcontrib>Wakata, Yoshifumi</creatorcontrib><creatorcontrib>Nakashima, Naoki</creatorcontrib><creatorcontrib>Kira, Jun-ichi</creatorcontrib><creatorcontrib>Murai, Hiroyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Koji</au><au>Yamada, Takeshi</au><au>Torii, Takako</au><au>Matsumoto, Shoji</au><au>Yoshimura, Takeo</au><au>Takase, Kei-ichiro</au><au>Wakata, Yoshifumi</au><au>Nakashima, Naoki</au><au>Kira, Jun-ichi</au><au>Murai, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive Factors for Excellent or Extremely Poor Functional Outcome in Initial Atrial Fibrillation-Related Cardioembolic Stroke</atitle><jtitle>European neurology</jtitle><addtitle>Eur Neurol</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>76</volume><issue>3-4</issue><spage>105</spage><epage>111</epage><pages>105-111</pages><issn>0014-3022</issn><eissn>1421-9913</eissn><abstract>Background: We aimed to determine the predictive factors for excellent or extremely poor functional outcome in patients with first-ever atrial fibrillation (AF)-related cardioembolic stroke. Methods: Retrospective observational study from a database. Patients with AF-related cardioembolic stroke with a premorbid modified Rankin Scale (mRS) score of 0 or 1 and without a previous history of stroke were included. Results: Factors associated with excellent functional outcome (mRS scores of 0 or 1; n = 77; 30.4% of patients) included age >78 years (OR 0.31, 95% CI 0.15-0.61), male sex (OR 2.16, 95% CI 1.04-4.60), absence of hypertension (OR 0.46, 95% CI 0.22-0.94) and initial National Institutes of Health Stroke Scale (NIHSS) score of >9 (OR 0.08, 95% CI 0.03-0.16). Factors associated with extremely poor functional outcome (mRS scores of 5 or 6; n = 63; 24.9%) included age >78 years (OR 3.30, 95% CI 1.54-7.39), initial NIHSS score of >9 (OR 12.38, 95% CI 5.40-32.56), congestive heart failure (OR 4.82, 95% CI 2.00-12.19) and ischemic heart disease (OR 4.02, 95% CI 1.18-14.69). Conclusions: Predictive factors exist to delineate excellent and extremely poor functional outcomes after a first-time stroke associated with AF.</abstract><cop>Basel, Switzerland</cop><pmid>27508927</pmid><doi>10.1159/000447629</doi><tpages>7</tpages></addata></record> |
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| subjects | Activities of Daily Living - classification Aged Aged, 80 and over Atrial Fibrillation - complications Atrial Fibrillation - therapy Diagnostic Imaging Disability Evaluation Female Humans Hypertension - complications Intracranial Embolism - classification Intracranial Embolism - diagnosis Intracranial Embolism - etiology Intracranial Embolism - therapy Ischemic Attack, Transient - classification Ischemic Attack, Transient - diagnosis Ischemic Attack, Transient - etiology Ischemic Attack, Transient - therapy Male Middle Aged Neurologic Examination Original Paper Outcome Assessment (Health Care) Prognosis Prospective Studies Retrospective Studies Risk Factors Stroke - classification Stroke - complications Stroke - diagnosis Stroke - etiology Stroke - therapy |
| title | Predictive Factors for Excellent or Extremely Poor Functional Outcome in Initial Atrial Fibrillation-Related Cardioembolic Stroke |
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