Tumor evasion of humoral immunity mediated by proteolytic impairment of antibody triggered immune effector function

Tumor evasion of humoral immunity mediated by proteolytic impairment of antibody triggered immune effector function

Immune suppression is recognized as a hallmark of cancer and this notion is largely based on studies on cellular immunity. Our recent studies have demonstrated a potential new mechanism of cancer suppression of immunity by impairment of antibody effector function mediated by proteolytic enzymes in t...

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Veröffentlicht in:Oncoimmunology 2016-05, Vol.5 (5), p.e1122861-e1122861
Hauptverfasser: Zhang, Ningyan, Jordan, Robert E., An, Zhiqiang
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Sprache:eng
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Antibody immunity
Author's View
cancer immune evasion
single proteolytic cleavage of the IgG hinge
tumor microenvironment
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container_title Oncoimmunology
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creator Zhang, Ningyan
Jordan, Robert E.
An, Zhiqiang
description Immune suppression is recognized as a hallmark of cancer and this notion is largely based on studies on cellular immunity. Our recent studies have demonstrated a potential new mechanism of cancer suppression of immunity by impairment of antibody effector function mediated by proteolytic enzymes in the tumor microenvironment.
doi_str_mv 10.1080/2162402X.2015.1122861
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2162-402X
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subjects Antibody immunity
Author's View
cancer immune evasion
single proteolytic cleavage of the IgG hinge
tumor microenvironment
title Tumor evasion of humoral immunity mediated by proteolytic impairment of antibody triggered immune effector function
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