Assessment of bioactive metabolites and hypolipidemic effect of polyphenolic-rich red cabbage extract
Context: Cardiovascular disease is the leading cause of death worldwide and the consumption of red cabbage (Brassica oleracea var. capitata f. rubra DC. - Brassicaceae) has been linked with the reduction risk of chronic diseases. Objective: The present study assesses the bioactive metabolites and hy...
Gespeichert in:
| Veröffentlicht in: | Pharmaceutical biology 2016-12, Vol.54 (12), p.3033-3039 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3039 |
|---|---|
| container_issue | 12 |
| container_start_page | 3033 |
| container_title | Pharmaceutical biology |
| container_volume | 54 |
| creator | Cruz, Alice Buss Pitz, Heloísa da Silva Veber, Bruno Bini, Larissa Alida Maraschin, Marcelo Zeni, Ana Lúcia Bertarello |
| description | Context: Cardiovascular disease is the leading cause of death worldwide and the consumption of red cabbage (Brassica oleracea var. capitata f. rubra DC. - Brassicaceae) has been linked with the reduction risk of chronic diseases.
Objective: The present study assesses the bioactive metabolites and hypolipidemic effect of red cabbage on rats.
Materials and methods: The content of total phenols, flavonoids, anthocyanins, carotenoids, ascorbic acid and antioxidant capacity were assessed, while individual phenolic acids and flavonoids were detected using reverse phase-high performance liquid chromatography (HPLC) analysis. Acute hypolipidemic activity of aqueous extract of red cabbage (RC - 125, 250 and 500 mg/kg) was investigated using a Triton WR-1339 (400 mg/kg) induced hyperlipidemic Wistar rats compared to fenofibrate (65 mg/kg).
Results: The HPLC analysis of extracts revealed eight phenolic acids, gallic, protocatechuic, p-hydroxybenzoic, m-coumaric, syringic, caffeic, cinnamic, dicaffeoylquinic and three flavonoids, epicatechin, epigallocatechin, gallocatechin. Furthermore, the aqueous extract showed higher amounts of total phenolics (116.00 mg/g), flavonoids (161.32 μg/g) and, antioxidant activity (87.19%) than the hydromethanolic (89.33 mg/g, 123.34 μg/g and 75.07%), respectively. The RC significantly (p |
| doi_str_mv | 10.1080/13880209.2016.1200633 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmed_primary_27436527</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>27436527</sourcerecordid><originalsourceid>FETCH-LOGICAL-c413t-3d5f3a4169d13cea0348177c2a67c6c7546f44be55729e6f0e04bc8ba7289fe43</originalsourceid><addsrcrecordid>eNp9kMlOwzAURS0EolD4BJB_IMWzkx1VxSRVYgPryHaeqVEm2WHI35PSliWrN917n3QQuqJkQUlObijPc8JIsWCEqgVlhCjOj9AZ1UJkklJ1PPWTJtuKZug8pXdCiORcnqIZ04IryfQZgmVKkFID7YA7j23ojBvCJ-AGBmO7OgyQsGkrvBn7aepDBU1wGLwH9-uYtmO_gXY6uiwGt8ERKuyMteYNMHwPcQq8QCfe1Aku93WOXu_vXlaP2fr54Wm1XGdOUD5kvJKeG0FVUVHuwBAucqq1Y0Zpp5yWQnkhLEipWQHKEyDCutwazfLCg-BzJHe5LnYpRfBlH0Nj4lhSUm6xlQds5RZbucc2-a53vv7DNlD9uQ6cJsHtThBa38XGfHWxrsrBjHUXfTStC6nk___4AZ95fcM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Assessment of bioactive metabolites and hypolipidemic effect of polyphenolic-rich red cabbage extract</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Cruz, Alice Buss ; Pitz, Heloísa da Silva ; Veber, Bruno ; Bini, Larissa Alida ; Maraschin, Marcelo ; Zeni, Ana Lúcia Bertarello</creator><creatorcontrib>Cruz, Alice Buss ; Pitz, Heloísa da Silva ; Veber, Bruno ; Bini, Larissa Alida ; Maraschin, Marcelo ; Zeni, Ana Lúcia Bertarello</creatorcontrib><description>Context: Cardiovascular disease is the leading cause of death worldwide and the consumption of red cabbage (Brassica oleracea var. capitata f. rubra DC. - Brassicaceae) has been linked with the reduction risk of chronic diseases.
Objective: The present study assesses the bioactive metabolites and hypolipidemic effect of red cabbage on rats.
Materials and methods: The content of total phenols, flavonoids, anthocyanins, carotenoids, ascorbic acid and antioxidant capacity were assessed, while individual phenolic acids and flavonoids were detected using reverse phase-high performance liquid chromatography (HPLC) analysis. Acute hypolipidemic activity of aqueous extract of red cabbage (RC - 125, 250 and 500 mg/kg) was investigated using a Triton WR-1339 (400 mg/kg) induced hyperlipidemic Wistar rats compared to fenofibrate (65 mg/kg).
Results: The HPLC analysis of extracts revealed eight phenolic acids, gallic, protocatechuic, p-hydroxybenzoic, m-coumaric, syringic, caffeic, cinnamic, dicaffeoylquinic and three flavonoids, epicatechin, epigallocatechin, gallocatechin. Furthermore, the aqueous extract showed higher amounts of total phenolics (116.00 mg/g), flavonoids (161.32 μg/g) and, antioxidant activity (87.19%) than the hydromethanolic (89.33 mg/g, 123.34 μg/g and 75.07%), respectively. The RC significantly (p < 0.001) ameliorated the levels of cholesterol, triglycerides and lipoproteins alterations in hyperlipidemic rats without toxicity.
Discussion and conclusion: Herein, the RC presented the higher amounts of phenolics and flavonoids comparing with the hydromethanolic extract. Additionally, the RC showed as the majority compounds, dicaffeoylquinic and cinnamic acids, and the flavonoids epicatechin and gallocatechin. Furthermore, the RC demonstrated a beneficial effect against hypercholesterolemia and hypertriglyceridemia, demonstrating its potential therapeutic effect on these risk factors of cardiovascular diseases.</description><identifier>ISSN: 1388-0209</identifier><identifier>EISSN: 1744-5116</identifier><identifier>DOI: 10.1080/13880209.2016.1200633</identifier><identifier>PMID: 27436527</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; Bioactive compounds ; Brassica ; Brassica oleareacea ; Cholesterol - blood ; Dose-Response Relationship, Drug ; Hyperlipidemias - blood ; Hyperlipidemias - drug therapy ; Hypolipidemic Agents - isolation & purification ; Hypolipidemic Agents - pharmacology ; Hypolipidemic Agents - therapeutic use ; hypolipidemic effect ; lipid profile ; phenolics ; Phytochemicals - isolation & purification ; Phytochemicals - pharmacology ; Phytochemicals - therapeutic use ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Polyphenols - isolation & purification ; Polyphenols - pharmacology ; Polyphenols - therapeutic use ; Rats ; Rats, Wistar ; Treatment Outcome ; Triglycerides - antagonists & inhibitors ; Triglycerides - blood ; Triton WR-1339</subject><ispartof>Pharmaceutical biology, 2016-12, Vol.54 (12), p.3033-3039</ispartof><rights>2016 Informa UK Limited, trading as Taylor & Francis Group 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-3d5f3a4169d13cea0348177c2a67c6c7546f44be55729e6f0e04bc8ba7289fe43</citedby><cites>FETCH-LOGICAL-c413t-3d5f3a4169d13cea0348177c2a67c6c7546f44be55729e6f0e04bc8ba7289fe43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27436527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cruz, Alice Buss</creatorcontrib><creatorcontrib>Pitz, Heloísa da Silva</creatorcontrib><creatorcontrib>Veber, Bruno</creatorcontrib><creatorcontrib>Bini, Larissa Alida</creatorcontrib><creatorcontrib>Maraschin, Marcelo</creatorcontrib><creatorcontrib>Zeni, Ana Lúcia Bertarello</creatorcontrib><title>Assessment of bioactive metabolites and hypolipidemic effect of polyphenolic-rich red cabbage extract</title><title>Pharmaceutical biology</title><addtitle>Pharm Biol</addtitle><description>Context: Cardiovascular disease is the leading cause of death worldwide and the consumption of red cabbage (Brassica oleracea var. capitata f. rubra DC. - Brassicaceae) has been linked with the reduction risk of chronic diseases.
Objective: The present study assesses the bioactive metabolites and hypolipidemic effect of red cabbage on rats.
Materials and methods: The content of total phenols, flavonoids, anthocyanins, carotenoids, ascorbic acid and antioxidant capacity were assessed, while individual phenolic acids and flavonoids were detected using reverse phase-high performance liquid chromatography (HPLC) analysis. Acute hypolipidemic activity of aqueous extract of red cabbage (RC - 125, 250 and 500 mg/kg) was investigated using a Triton WR-1339 (400 mg/kg) induced hyperlipidemic Wistar rats compared to fenofibrate (65 mg/kg).
Results: The HPLC analysis of extracts revealed eight phenolic acids, gallic, protocatechuic, p-hydroxybenzoic, m-coumaric, syringic, caffeic, cinnamic, dicaffeoylquinic and three flavonoids, epicatechin, epigallocatechin, gallocatechin. Furthermore, the aqueous extract showed higher amounts of total phenolics (116.00 mg/g), flavonoids (161.32 μg/g) and, antioxidant activity (87.19%) than the hydromethanolic (89.33 mg/g, 123.34 μg/g and 75.07%), respectively. The RC significantly (p < 0.001) ameliorated the levels of cholesterol, triglycerides and lipoproteins alterations in hyperlipidemic rats without toxicity.
Discussion and conclusion: Herein, the RC presented the higher amounts of phenolics and flavonoids comparing with the hydromethanolic extract. Additionally, the RC showed as the majority compounds, dicaffeoylquinic and cinnamic acids, and the flavonoids epicatechin and gallocatechin. Furthermore, the RC demonstrated a beneficial effect against hypercholesterolemia and hypertriglyceridemia, demonstrating its potential therapeutic effect on these risk factors of cardiovascular diseases.</description><subject>Animals</subject><subject>Bioactive compounds</subject><subject>Brassica</subject><subject>Brassica oleareacea</subject><subject>Cholesterol - blood</subject><subject>Dose-Response Relationship, Drug</subject><subject>Hyperlipidemias - blood</subject><subject>Hyperlipidemias - drug therapy</subject><subject>Hypolipidemic Agents - isolation & purification</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>Hypolipidemic Agents - therapeutic use</subject><subject>hypolipidemic effect</subject><subject>lipid profile</subject><subject>phenolics</subject><subject>Phytochemicals - isolation & purification</subject><subject>Phytochemicals - pharmacology</subject><subject>Phytochemicals - therapeutic use</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Polyphenols - isolation & purification</subject><subject>Polyphenols - pharmacology</subject><subject>Polyphenols - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Treatment Outcome</subject><subject>Triglycerides - antagonists & inhibitors</subject><subject>Triglycerides - blood</subject><subject>Triton WR-1339</subject><issn>1388-0209</issn><issn>1744-5116</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAURS0EolD4BJB_IMWzkx1VxSRVYgPryHaeqVEm2WHI35PSliWrN917n3QQuqJkQUlObijPc8JIsWCEqgVlhCjOj9AZ1UJkklJ1PPWTJtuKZug8pXdCiORcnqIZ04IryfQZgmVKkFID7YA7j23ojBvCJ-AGBmO7OgyQsGkrvBn7aepDBU1wGLwH9-uYtmO_gXY6uiwGt8ERKuyMteYNMHwPcQq8QCfe1Aku93WOXu_vXlaP2fr54Wm1XGdOUD5kvJKeG0FVUVHuwBAucqq1Y0Zpp5yWQnkhLEipWQHKEyDCutwazfLCg-BzJHe5LnYpRfBlH0Nj4lhSUm6xlQds5RZbucc2-a53vv7DNlD9uQ6cJsHtThBa38XGfHWxrsrBjHUXfTStC6nk___4AZ95fcM</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Cruz, Alice Buss</creator><creator>Pitz, Heloísa da Silva</creator><creator>Veber, Bruno</creator><creator>Bini, Larissa Alida</creator><creator>Maraschin, Marcelo</creator><creator>Zeni, Ana Lúcia Bertarello</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20161201</creationdate><title>Assessment of bioactive metabolites and hypolipidemic effect of polyphenolic-rich red cabbage extract</title><author>Cruz, Alice Buss ; Pitz, Heloísa da Silva ; Veber, Bruno ; Bini, Larissa Alida ; Maraschin, Marcelo ; Zeni, Ana Lúcia Bertarello</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-3d5f3a4169d13cea0348177c2a67c6c7546f44be55729e6f0e04bc8ba7289fe43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Bioactive compounds</topic><topic>Brassica</topic><topic>Brassica oleareacea</topic><topic>Cholesterol - blood</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hyperlipidemias - blood</topic><topic>Hyperlipidemias - drug therapy</topic><topic>Hypolipidemic Agents - isolation & purification</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>Hypolipidemic Agents - therapeutic use</topic><topic>hypolipidemic effect</topic><topic>lipid profile</topic><topic>phenolics</topic><topic>Phytochemicals - isolation & purification</topic><topic>Phytochemicals - pharmacology</topic><topic>Phytochemicals - therapeutic use</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Polyphenols - isolation & purification</topic><topic>Polyphenols - pharmacology</topic><topic>Polyphenols - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Treatment Outcome</topic><topic>Triglycerides - antagonists & inhibitors</topic><topic>Triglycerides - blood</topic><topic>Triton WR-1339</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cruz, Alice Buss</creatorcontrib><creatorcontrib>Pitz, Heloísa da Silva</creatorcontrib><creatorcontrib>Veber, Bruno</creatorcontrib><creatorcontrib>Bini, Larissa Alida</creatorcontrib><creatorcontrib>Maraschin, Marcelo</creatorcontrib><creatorcontrib>Zeni, Ana Lúcia Bertarello</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Pharmaceutical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cruz, Alice Buss</au><au>Pitz, Heloísa da Silva</au><au>Veber, Bruno</au><au>Bini, Larissa Alida</au><au>Maraschin, Marcelo</au><au>Zeni, Ana Lúcia Bertarello</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of bioactive metabolites and hypolipidemic effect of polyphenolic-rich red cabbage extract</atitle><jtitle>Pharmaceutical biology</jtitle><addtitle>Pharm Biol</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>54</volume><issue>12</issue><spage>3033</spage><epage>3039</epage><pages>3033-3039</pages><issn>1388-0209</issn><eissn>1744-5116</eissn><abstract>Context: Cardiovascular disease is the leading cause of death worldwide and the consumption of red cabbage (Brassica oleracea var. capitata f. rubra DC. - Brassicaceae) has been linked with the reduction risk of chronic diseases.
Objective: The present study assesses the bioactive metabolites and hypolipidemic effect of red cabbage on rats.
Materials and methods: The content of total phenols, flavonoids, anthocyanins, carotenoids, ascorbic acid and antioxidant capacity were assessed, while individual phenolic acids and flavonoids were detected using reverse phase-high performance liquid chromatography (HPLC) analysis. Acute hypolipidemic activity of aqueous extract of red cabbage (RC - 125, 250 and 500 mg/kg) was investigated using a Triton WR-1339 (400 mg/kg) induced hyperlipidemic Wistar rats compared to fenofibrate (65 mg/kg).
Results: The HPLC analysis of extracts revealed eight phenolic acids, gallic, protocatechuic, p-hydroxybenzoic, m-coumaric, syringic, caffeic, cinnamic, dicaffeoylquinic and three flavonoids, epicatechin, epigallocatechin, gallocatechin. Furthermore, the aqueous extract showed higher amounts of total phenolics (116.00 mg/g), flavonoids (161.32 μg/g) and, antioxidant activity (87.19%) than the hydromethanolic (89.33 mg/g, 123.34 μg/g and 75.07%), respectively. The RC significantly (p < 0.001) ameliorated the levels of cholesterol, triglycerides and lipoproteins alterations in hyperlipidemic rats without toxicity.
Discussion and conclusion: Herein, the RC presented the higher amounts of phenolics and flavonoids comparing with the hydromethanolic extract. Additionally, the RC showed as the majority compounds, dicaffeoylquinic and cinnamic acids, and the flavonoids epicatechin and gallocatechin. Furthermore, the RC demonstrated a beneficial effect against hypercholesterolemia and hypertriglyceridemia, demonstrating its potential therapeutic effect on these risk factors of cardiovascular diseases.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>27436527</pmid><doi>10.1080/13880209.2016.1200633</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1388-0209 |
| ispartof | Pharmaceutical biology, 2016-12, Vol.54 (12), p.3033-3039 |
| issn | 1388-0209 1744-5116 |
| language | eng |
| recordid | cdi_pubmed_primary_27436527 |
| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Bioactive compounds Brassica Brassica oleareacea Cholesterol - blood Dose-Response Relationship, Drug Hyperlipidemias - blood Hyperlipidemias - drug therapy Hypolipidemic Agents - isolation & purification Hypolipidemic Agents - pharmacology Hypolipidemic Agents - therapeutic use hypolipidemic effect lipid profile phenolics Phytochemicals - isolation & purification Phytochemicals - pharmacology Phytochemicals - therapeutic use Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - therapeutic use Polyphenols - isolation & purification Polyphenols - pharmacology Polyphenols - therapeutic use Rats Rats, Wistar Treatment Outcome Triglycerides - antagonists & inhibitors Triglycerides - blood Triton WR-1339 |
| title | Assessment of bioactive metabolites and hypolipidemic effect of polyphenolic-rich red cabbage extract |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T17%3A56%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20bioactive%20metabolites%20and%20hypolipidemic%20effect%20of%20polyphenolic-rich%20red%20cabbage%20extract&rft.jtitle=Pharmaceutical%20biology&rft.au=Cruz,%20Alice%20Buss&rft.date=2016-12-01&rft.volume=54&rft.issue=12&rft.spage=3033&rft.epage=3039&rft.pages=3033-3039&rft.issn=1388-0209&rft.eissn=1744-5116&rft_id=info:doi/10.1080/13880209.2016.1200633&rft_dat=%3Cpubmed_cross%3E27436527%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/27436527&rfr_iscdi=true |