Stability of Doxycycline in Feed and Water and Minimal Effective Doses in Tetracycline-Inducible Systems

Despite the extensive use of doxycycline in tetracycline-inducible rodent models, little is known regarding its stability in feed or water or the most effective route or dose. We assessed the concentrations of doxycycline in reverse-osmosis-purified (RO; pH 6.0) and acidified RO (pH 2.6) water in un...

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Veröffentlicht in:	Journal of the American Association for Laboratory Animal Science 2016-07, Vol.55 (4), p.467-474
Hauptverfasser:	Redelsperger, Irka M, Taldone, Tony, Riedel, Elyn R, Lepherd, Michelle L, Lipman, Neil S, Wolf, Felix R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Feed Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Doxycycline - administration & dosage Doxycycline - blood Doxycycline - chemistry Experimental Use Female Male Mice Mice, Inbred C57BL Tetracycline - pharmacology Water - chemistry
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