NDRG1 overexpression promotes the progression of esophageal squamous cell carcinoma through modulating Wnt signaling pathway

N-myc down-regulated gene 1 (NDRG1) has been shown to regulate tumor growth and metastasis in various malignant tumors and also to be dysregulated in esophageal squamous cell carcinoma (ESCC). Here, we show that NDRG1 overexpression (91.9%, 79/86) in ESCC tumor tissues is associated with poor overal...

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Veröffentlicht in:	Cancer biology & therapy 2016-09, Vol.17 (9), p.943-954
Hauptverfasser:	Ai, Runna, Sun, Yulin, Guo, Zhimin, Wei, Wei, Zhou, Lanping, Liu, Fang, Hendricks, Denver T., Xu, Yang, Zhao, Xiaohang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Cycle Proteins - biosynthesis Cell Line, Tumor Disease Progression EMT esophageal cancer Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma Female Genes, myc Heterografts Humans Intracellular Signaling Peptides and Proteins - biosynthesis Mice Mice, Nude NDRG1 Research Paper TLE2 Transfection Wnt pathway Wnt Signaling Pathway β-catenin
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