Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes

Design, synthesis and evaluation of very potent and selective β-secretase 2 (memapsin 1, BACE 2) inhibitors are described. The inhibitors were designed specifically to interact with the S2′-site of β-secretase 2 to provide >170 000-fold selectivity over β-secretase (BACE 1) and >15 000-fold se...

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Veröffentlicht in:	Chemical science (Cambridge) 2016-01, Vol.7 (5), p.3117-3122
Hauptverfasser:	Ghosh, Arun K, Reddy, Bhavanam Sekhara, Yen, Yu-Chen, Cárdenas, Emilio L, Rao, Kalapala Venkateswara, Downs, Deborah, Huang, Xiangping, Tang, Jordan, Mesecar, Andrew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Cathepsin D Design analysis Diabetes Human Inhibitors Selectivity Synthesis
Online-Zugang:	Volltext
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