Endothelial progenitor cells mobilisation after percutaneous coronary intervention: a pilot study
Background: The mobilisation process of endothelial progenitor cells (EPC) after stent implantation by percutaneous coronary intervention (PCI) is unclear because the circulating EPC levels are influenced by several pathophysiological factors. The objective was to analyse the kinetics of EPC concent...
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| Veröffentlicht in: | British journal of biomedical science 2016-10, Vol.73 (4), p.194-200 |
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| creator | Santas-Álvarez, Melisa Rodiño-Janeiro, Bruno K. Paradela-Dobarro, Beatriz López-Otero, Diego Viñuela-Roldán, Juan E. Castiñeiras-Landeira, María I. González-Juanatey, José R. Trillo-Nouche, Ramiro Álvarez, Ezequiel |
| description | Background: The mobilisation process of endothelial progenitor cells (EPC) after stent implantation by percutaneous coronary intervention (PCI) is unclear because the circulating EPC levels are influenced by several pathophysiological factors. The objective was to analyse the kinetics of EPC concentration following elective PCI in patients with stable angina, and its relation with other biomarkers or parameters of cardiovascular function.
Methods: Pilot study in stable angina patients (n = 30) for elective PCI and implantation of bare-metal stent (BMS), drug-eluting stent (DES) or EPC-capturing stent (ECS). Samples were taken at baseline, 6 h, 24 h and 6 months after PCI for biochemical analysis and EPC quantification by flow cytometry.
Results: Baseline EPC levels, quantified in peripheral blood, were related with the extent of the coronary lesion and the percentage of stenosis. EPC concentration increased 6 hours after PCI in relation with plasma C-reactive protein concentration and returned to basal levels after 24 hours post-PCI.
Conclusions: Baseline EPC levels are related with the extension of the lesion and stenosis whereas the kinetics of EPC mobilization showed to be related with C-reactive protein concentration. Endothelial activation seems to occur in response to EPC mobilization or vascular damage by PCI. |
| doi_str_mv | 10.1080/09674845.2016.1190539 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_27310267</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1826701946</sourcerecordid><originalsourceid>FETCH-LOGICAL-c394t-2dd78868454d2d96b26c58d8ecc4d7447eef25fff5b63f73c2062fb7128bed073</originalsourceid><addsrcrecordid>eNp9kT9vFDEQxS0URI6EjwCylIZmD9vrtb2pEkUhIEWiIbXl9R9w5LUP2wu6b49Xd0mRItUU85uZ9-YB8BGjLUYCfUEj41TQYUsQZluMRzT04xuwIZTTDomRnYDNynQrdArel_KIEB4JZ-_AKeE9RoTxDVC30aT62wavAtzl9MtGX1OG2oZQ4JwmH3xR1acIlas2w53Neqkq2rQUqFNOUeU99LH1_tq4gpdQwZ0PqcJSF7M_B2-dCsV-ONYz8PD19ufNt-7-x933m-v7TvcjrR0xhgvBmlhqiBnZRJgehBFWa2o4pdxaRwbn3DCx3vFeE8SImzgmYrIG8f4MfD7sbS7-LLZUOfuy2jholVg0w-0DlDX04gX6mJYcm7pGDXwQggjSqOFA6ZxKydbJXfZzcysxkmsG8ikDuWYgjxm0uU_H7cs0W_M89fT0BlwdAB9dyrP6l3Iwsqp9SNllFbUvsn_9xn8nlJd7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1857588282</pqid></control><display><type>article</type><title>Endothelial progenitor cells mobilisation after percutaneous coronary intervention: a pilot study</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Santas-Álvarez, Melisa ; Rodiño-Janeiro, Bruno K. ; Paradela-Dobarro, Beatriz ; López-Otero, Diego ; Viñuela-Roldán, Juan E. ; Castiñeiras-Landeira, María I. ; González-Juanatey, José R. ; Trillo-Nouche, Ramiro ; Álvarez, Ezequiel</creator><creatorcontrib>Santas-Álvarez, Melisa ; Rodiño-Janeiro, Bruno K. ; Paradela-Dobarro, Beatriz ; López-Otero, Diego ; Viñuela-Roldán, Juan E. ; Castiñeiras-Landeira, María I. ; González-Juanatey, José R. ; Trillo-Nouche, Ramiro ; Álvarez, Ezequiel</creatorcontrib><description>Background: The mobilisation process of endothelial progenitor cells (EPC) after stent implantation by percutaneous coronary intervention (PCI) is unclear because the circulating EPC levels are influenced by several pathophysiological factors. The objective was to analyse the kinetics of EPC concentration following elective PCI in patients with stable angina, and its relation with other biomarkers or parameters of cardiovascular function.
Methods: Pilot study in stable angina patients (n = 30) for elective PCI and implantation of bare-metal stent (BMS), drug-eluting stent (DES) or EPC-capturing stent (ECS). Samples were taken at baseline, 6 h, 24 h and 6 months after PCI for biochemical analysis and EPC quantification by flow cytometry.
Results: Baseline EPC levels, quantified in peripheral blood, were related with the extent of the coronary lesion and the percentage of stenosis. EPC concentration increased 6 hours after PCI in relation with plasma C-reactive protein concentration and returned to basal levels after 24 hours post-PCI.
Conclusions: Baseline EPC levels are related with the extension of the lesion and stenosis whereas the kinetics of EPC mobilization showed to be related with C-reactive protein concentration. Endothelial activation seems to occur in response to EPC mobilization or vascular damage by PCI.</description><identifier>ISSN: 0967-4845</identifier><identifier>EISSN: 2474-0896</identifier><identifier>DOI: 10.1080/09674845.2016.1190539</identifier><identifier>PMID: 27310267</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Acute coronary syndromes ; Age ; Aged ; Angina pectoris ; Angina, Stable - blood ; Angina, Stable - therapy ; Angioplasty ; Bone marrow ; C-Reactive Protein - metabolism ; Cardiovascular disease ; Cell Movement ; Coronary vessels ; Diabetes ; elective percutaneous coronary intervention ; Endothelial progenitor cells ; Endothelial Progenitor Cells - metabolism ; endothelial progenitor cells mobilization ; Family medical history ; Female ; Flow Cytometry ; Heart attacks ; Hematopoietic Stem Cell Mobilization ; Humans ; Kinetics ; Male ; Middle Aged ; Patients ; Percutaneous Coronary Intervention - methods ; Pilot Projects ; stent implantation ; Stents ; Time Factors ; Variables</subject><ispartof>British journal of biomedical science, 2016-10, Vol.73 (4), p.194-200</ispartof><rights>2016 British Journal of Biomedical Science 2016</rights><rights>Copyright Taylor & Francis Ltd. 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-2dd78868454d2d96b26c58d8ecc4d7447eef25fff5b63f73c2062fb7128bed073</citedby><cites>FETCH-LOGICAL-c394t-2dd78868454d2d96b26c58d8ecc4d7447eef25fff5b63f73c2062fb7128bed073</cites><orcidid>0000-0002-2381-8425</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27310267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santas-Álvarez, Melisa</creatorcontrib><creatorcontrib>Rodiño-Janeiro, Bruno K.</creatorcontrib><creatorcontrib>Paradela-Dobarro, Beatriz</creatorcontrib><creatorcontrib>López-Otero, Diego</creatorcontrib><creatorcontrib>Viñuela-Roldán, Juan E.</creatorcontrib><creatorcontrib>Castiñeiras-Landeira, María I.</creatorcontrib><creatorcontrib>González-Juanatey, José R.</creatorcontrib><creatorcontrib>Trillo-Nouche, Ramiro</creatorcontrib><creatorcontrib>Álvarez, Ezequiel</creatorcontrib><title>Endothelial progenitor cells mobilisation after percutaneous coronary intervention: a pilot study</title><title>British journal of biomedical science</title><addtitle>Br J Biomed Sci</addtitle><description>Background: The mobilisation process of endothelial progenitor cells (EPC) after stent implantation by percutaneous coronary intervention (PCI) is unclear because the circulating EPC levels are influenced by several pathophysiological factors. The objective was to analyse the kinetics of EPC concentration following elective PCI in patients with stable angina, and its relation with other biomarkers or parameters of cardiovascular function.
Methods: Pilot study in stable angina patients (n = 30) for elective PCI and implantation of bare-metal stent (BMS), drug-eluting stent (DES) or EPC-capturing stent (ECS). Samples were taken at baseline, 6 h, 24 h and 6 months after PCI for biochemical analysis and EPC quantification by flow cytometry.
Results: Baseline EPC levels, quantified in peripheral blood, were related with the extent of the coronary lesion and the percentage of stenosis. EPC concentration increased 6 hours after PCI in relation with plasma C-reactive protein concentration and returned to basal levels after 24 hours post-PCI.
Conclusions: Baseline EPC levels are related with the extension of the lesion and stenosis whereas the kinetics of EPC mobilization showed to be related with C-reactive protein concentration. Endothelial activation seems to occur in response to EPC mobilization or vascular damage by PCI.</description><subject>Acute coronary syndromes</subject><subject>Age</subject><subject>Aged</subject><subject>Angina pectoris</subject><subject>Angina, Stable - blood</subject><subject>Angina, Stable - therapy</subject><subject>Angioplasty</subject><subject>Bone marrow</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular disease</subject><subject>Cell Movement</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>elective percutaneous coronary intervention</subject><subject>Endothelial progenitor cells</subject><subject>Endothelial Progenitor Cells - metabolism</subject><subject>endothelial progenitor cells mobilization</subject><subject>Family medical history</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Heart attacks</subject><subject>Hematopoietic Stem Cell Mobilization</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Percutaneous Coronary Intervention - methods</subject><subject>Pilot Projects</subject><subject>stent implantation</subject><subject>Stents</subject><subject>Time Factors</subject><subject>Variables</subject><issn>0967-4845</issn><issn>2474-0896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kT9vFDEQxS0URI6EjwCylIZmD9vrtb2pEkUhIEWiIbXl9R9w5LUP2wu6b49Xd0mRItUU85uZ9-YB8BGjLUYCfUEj41TQYUsQZluMRzT04xuwIZTTDomRnYDNynQrdArel_KIEB4JZ-_AKeE9RoTxDVC30aT62wavAtzl9MtGX1OG2oZQ4JwmH3xR1acIlas2w53Neqkq2rQUqFNOUeU99LH1_tq4gpdQwZ0PqcJSF7M_B2-dCsV-ONYz8PD19ufNt-7-x933m-v7TvcjrR0xhgvBmlhqiBnZRJgehBFWa2o4pdxaRwbn3DCx3vFeE8SImzgmYrIG8f4MfD7sbS7-LLZUOfuy2jholVg0w-0DlDX04gX6mJYcm7pGDXwQggjSqOFA6ZxKydbJXfZzcysxkmsG8ikDuWYgjxm0uU_H7cs0W_M89fT0BlwdAB9dyrP6l3Iwsqp9SNllFbUvsn_9xn8nlJd7</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Santas-Álvarez, Melisa</creator><creator>Rodiño-Janeiro, Bruno K.</creator><creator>Paradela-Dobarro, Beatriz</creator><creator>López-Otero, Diego</creator><creator>Viñuela-Roldán, Juan E.</creator><creator>Castiñeiras-Landeira, María I.</creator><creator>González-Juanatey, José R.</creator><creator>Trillo-Nouche, Ramiro</creator><creator>Álvarez, Ezequiel</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2381-8425</orcidid></search><sort><creationdate>20161001</creationdate><title>Endothelial progenitor cells mobilisation after percutaneous coronary intervention: a pilot study</title><author>Santas-Álvarez, Melisa ; Rodiño-Janeiro, Bruno K. ; Paradela-Dobarro, Beatriz ; López-Otero, Diego ; Viñuela-Roldán, Juan E. ; Castiñeiras-Landeira, María I. ; González-Juanatey, José R. ; Trillo-Nouche, Ramiro ; Álvarez, Ezequiel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-2dd78868454d2d96b26c58d8ecc4d7447eef25fff5b63f73c2062fb7128bed073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute coronary syndromes</topic><topic>Age</topic><topic>Aged</topic><topic>Angina pectoris</topic><topic>Angina, Stable - blood</topic><topic>Angina, Stable - therapy</topic><topic>Angioplasty</topic><topic>Bone marrow</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiovascular disease</topic><topic>Cell Movement</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>elective percutaneous coronary intervention</topic><topic>Endothelial progenitor cells</topic><topic>Endothelial Progenitor Cells - metabolism</topic><topic>endothelial progenitor cells mobilization</topic><topic>Family medical history</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Heart attacks</topic><topic>Hematopoietic Stem Cell Mobilization</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Percutaneous Coronary Intervention - methods</topic><topic>Pilot Projects</topic><topic>stent implantation</topic><topic>Stents</topic><topic>Time Factors</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santas-Álvarez, Melisa</creatorcontrib><creatorcontrib>Rodiño-Janeiro, Bruno K.</creatorcontrib><creatorcontrib>Paradela-Dobarro, Beatriz</creatorcontrib><creatorcontrib>López-Otero, Diego</creatorcontrib><creatorcontrib>Viñuela-Roldán, Juan E.</creatorcontrib><creatorcontrib>Castiñeiras-Landeira, María I.</creatorcontrib><creatorcontrib>González-Juanatey, José R.</creatorcontrib><creatorcontrib>Trillo-Nouche, Ramiro</creatorcontrib><creatorcontrib>Álvarez, Ezequiel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of biomedical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santas-Álvarez, Melisa</au><au>Rodiño-Janeiro, Bruno K.</au><au>Paradela-Dobarro, Beatriz</au><au>López-Otero, Diego</au><au>Viñuela-Roldán, Juan E.</au><au>Castiñeiras-Landeira, María I.</au><au>González-Juanatey, José R.</au><au>Trillo-Nouche, Ramiro</au><au>Álvarez, Ezequiel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial progenitor cells mobilisation after percutaneous coronary intervention: a pilot study</atitle><jtitle>British journal of biomedical science</jtitle><addtitle>Br J Biomed Sci</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>73</volume><issue>4</issue><spage>194</spage><epage>200</epage><pages>194-200</pages><issn>0967-4845</issn><eissn>2474-0896</eissn><abstract>Background: The mobilisation process of endothelial progenitor cells (EPC) after stent implantation by percutaneous coronary intervention (PCI) is unclear because the circulating EPC levels are influenced by several pathophysiological factors. The objective was to analyse the kinetics of EPC concentration following elective PCI in patients with stable angina, and its relation with other biomarkers or parameters of cardiovascular function.
Methods: Pilot study in stable angina patients (n = 30) for elective PCI and implantation of bare-metal stent (BMS), drug-eluting stent (DES) or EPC-capturing stent (ECS). Samples were taken at baseline, 6 h, 24 h and 6 months after PCI for biochemical analysis and EPC quantification by flow cytometry.
Results: Baseline EPC levels, quantified in peripheral blood, were related with the extent of the coronary lesion and the percentage of stenosis. EPC concentration increased 6 hours after PCI in relation with plasma C-reactive protein concentration and returned to basal levels after 24 hours post-PCI.
Conclusions: Baseline EPC levels are related with the extension of the lesion and stenosis whereas the kinetics of EPC mobilization showed to be related with C-reactive protein concentration. Endothelial activation seems to occur in response to EPC mobilization or vascular damage by PCI.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>27310267</pmid><doi>10.1080/09674845.2016.1190539</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2381-8425</orcidid></addata></record> |
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| subjects | Acute coronary syndromes Age Aged Angina pectoris Angina, Stable - blood Angina, Stable - therapy Angioplasty Bone marrow C-Reactive Protein - metabolism Cardiovascular disease Cell Movement Coronary vessels Diabetes elective percutaneous coronary intervention Endothelial progenitor cells Endothelial Progenitor Cells - metabolism endothelial progenitor cells mobilization Family medical history Female Flow Cytometry Heart attacks Hematopoietic Stem Cell Mobilization Humans Kinetics Male Middle Aged Patients Percutaneous Coronary Intervention - methods Pilot Projects stent implantation Stents Time Factors Variables |
| title | Endothelial progenitor cells mobilisation after percutaneous coronary intervention: a pilot study |
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