Association of Choroidal Interleukin-17-Producing T Lymphocytes and Macrophages with Geographic Atrophy
Purpose: To evaluate the presence of interleukin-17 (IL-17)-producing cells in patients with geographic atrophy (GA). Methods: In this short report, we analyzed IL-17, CD3, and IBA-1 expression by immunohistochemistry on paraffin-embedded sections from 13 donors with a known history of GA, confirmed...
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| Veröffentlicht in: | Ophthalmologica (Basel) 2016-01, Vol.236 (1), p.53-58 |
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| creator | Camelo, Serge Lavelette, Sophie Guillonneau, Xavier Raoul, William Sennlaub, Florian |
| description | Purpose: To evaluate the presence of interleukin-17 (IL-17)-producing cells in patients with geographic atrophy (GA). Methods: In this short report, we analyzed IL-17, CD3, and IBA-1 expression by immunohistochemistry on paraffin-embedded sections from 13 donors with a known history of GA, confirmed by fundus appearance and histology, and 7 age-matched control donors. Results/Conclusion: We showed that IL-17 + cells are found near areas of retinal pigmented epithelium atrophy in the eyes of GA patients. IL-17 + cells mainly localized to CD3 + cells, which identifies T lymphocytes, as well as IBA-1 + cells, which identifies mononuclear phagocytes. Therefore, IL-17 could be involved in the pathological mechanisms that contribute to the degeneration observed in GA. |
| doi_str_mv | 10.1159/000446587 |
| format | Article |
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Methods: In this short report, we analyzed IL-17, CD3, and IBA-1 expression by immunohistochemistry on paraffin-embedded sections from 13 donors with a known history of GA, confirmed by fundus appearance and histology, and 7 age-matched control donors. Results/Conclusion: We showed that IL-17 + cells are found near areas of retinal pigmented epithelium atrophy in the eyes of GA patients. IL-17 + cells mainly localized to CD3 + cells, which identifies T lymphocytes, as well as IBA-1 + cells, which identifies mononuclear phagocytes. Therefore, IL-17 could be involved in the pathological mechanisms that contribute to the degeneration observed in GA.</description><identifier>ISSN: 0030-3755</identifier><identifier>EISSN: 1423-0267</identifier><identifier>DOI: 10.1159/000446587</identifier><identifier>PMID: 27287199</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Aged, 80 and over ; Choroid - immunology ; Choroid - pathology ; Female ; Fluorescein Angiography ; Fundus Oculi ; Geographic Atrophy - immunology ; Geographic Atrophy - metabolism ; Geographic Atrophy - pathology ; Humans ; Immunity, Cellular ; Immunohistochemistry ; Interleukin-17 - biosynthesis ; Macrophages - immunology ; Macrophages - metabolism ; Macrophages - pathology ; Male ; Original Paper ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; T-Lymphocytes - pathology</subject><ispartof>Ophthalmologica (Basel), 2016-01, Vol.236 (1), p.53-58</ispartof><rights>2016 S. Karger AG, Basel</rights><rights>2016 S. 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Methods: In this short report, we analyzed IL-17, CD3, and IBA-1 expression by immunohistochemistry on paraffin-embedded sections from 13 donors with a known history of GA, confirmed by fundus appearance and histology, and 7 age-matched control donors. Results/Conclusion: We showed that IL-17 + cells are found near areas of retinal pigmented epithelium atrophy in the eyes of GA patients. IL-17 + cells mainly localized to CD3 + cells, which identifies T lymphocytes, as well as IBA-1 + cells, which identifies mononuclear phagocytes. Therefore, IL-17 could be involved in the pathological mechanisms that contribute to the degeneration observed in GA.</description><subject>Aged, 80 and over</subject><subject>Choroid - immunology</subject><subject>Choroid - pathology</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Fundus Oculi</subject><subject>Geographic Atrophy - immunology</subject><subject>Geographic Atrophy - metabolism</subject><subject>Geographic Atrophy - pathology</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Immunohistochemistry</subject><subject>Interleukin-17 - biosynthesis</subject><subject>Macrophages - immunology</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - pathology</subject><subject>Male</subject><subject>Original Paper</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>T-Lymphocytes - pathology</subject><issn>0030-3755</issn><issn>1423-0267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0M9LwzAUB_AgipvTg3eRgBc9VPOrTXscQ-dgood5LmmatpltU5MW6X9vxuYOnsIjn_d47wvANUaPGIfJE0KIsSiM-QmYYkZogEjET8EUIYoCysNwAi6c2yLkcYLPwYRwEnOcJFNQzp0zUotemxaaAi4qY43ORQ1Xba9srYYv3QaYBx_W5IPUbQk3cD02XWXk2CsHRZvDNyGt6SpR-vpH9xVcKlNa0VVawnm_-xovwVkhaqeuDu8MfL48bxavwfp9uVrM14GkUdIHihSYcCXCjEU0wYrlSKiY0QzneYYELViWUcpIJAsswligiMosJDGhMkGKSzoD9_u5nTXfg3J92mgnVV2LVpnBpTjGmCSMUebp3T-6NYNt_XY7FRHCMUVePeyVP9E5q4q0s7oRdkwxSnfpp8f0vb09TByyRuVH-Re3Bzd78CVsqewRHPp_AcRsh-E</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Camelo, Serge</creator><creator>Lavelette, Sophie</creator><creator>Guillonneau, Xavier</creator><creator>Raoul, William</creator><creator>Sennlaub, Florian</creator><general>S. 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Methods: In this short report, we analyzed IL-17, CD3, and IBA-1 expression by immunohistochemistry on paraffin-embedded sections from 13 donors with a known history of GA, confirmed by fundus appearance and histology, and 7 age-matched control donors. Results/Conclusion: We showed that IL-17 + cells are found near areas of retinal pigmented epithelium atrophy in the eyes of GA patients. IL-17 + cells mainly localized to CD3 + cells, which identifies T lymphocytes, as well as IBA-1 + cells, which identifies mononuclear phagocytes. Therefore, IL-17 could be involved in the pathological mechanisms that contribute to the degeneration observed in GA.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>27287199</pmid><doi>10.1159/000446587</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Karger Journals |
| subjects | Aged, 80 and over Choroid - immunology Choroid - pathology Female Fluorescein Angiography Fundus Oculi Geographic Atrophy - immunology Geographic Atrophy - metabolism Geographic Atrophy - pathology Humans Immunity, Cellular Immunohistochemistry Interleukin-17 - biosynthesis Macrophages - immunology Macrophages - metabolism Macrophages - pathology Male Original Paper T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology |
| title | Association of Choroidal Interleukin-17-Producing T Lymphocytes and Macrophages with Geographic Atrophy |
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