Small Molecule Recognition and Tools to Study Modulation of r(CGG)(exp) in Fragile X-Associated Tremor Ataxia Syndrome

RNA transcripts containing expanded nucleotide repeats cause many incurable diseases via various mechanisms. One such disorder, fragile X-associated tremor ataxia syndrome (FXTAS), is caused by a noncoding r(CGG) repeat expansion (r(CGG)(exp)) that (i) sequesters proteins involved in RNA metabolism...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS chemical biology 2016-09, Vol.11 (9), p.2456
Hauptverfasser:	Yang, Wang-Yong, He, Fang, Strack, Rita L, Oh, Seok Yoon, Frazer, Michelle, Jaffrey, Samie R, Todd, Peter K, Disney, Matthew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia - genetics Fragile X Syndrome - genetics HeLa Cells Humans RNA Splicing RNA, Messenger - genetics Tremor - genetics Trinucleotide Repeats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!