Noncontact speckle-based optical sensor for detection of glucose concentration using magneto-optic effect
We experimentally verify a speckle-based technique for noncontact measurement of glucose concentration in the bloodstream. The final device is intended to be a single wristwatch-style device containing a laser, a camera, and an alternating current (ac) electromagnet generated by a solenoid. The expe...
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Veröffentlicht in: | Journal of biomedical optics 2016-06, Vol.21 (6), p.065001-065001 |
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container_title | Journal of biomedical optics |
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creator | Ozana, Nisan Beiderman, Yevgeny Anand, Arun Javidi, Baharam Polani, Sagi Schwarz, Ariel Shemer, Amir Garcia, Javier Zalevsky, Zeev |
description | We experimentally verify a speckle-based technique for noncontact measurement of glucose concentration in the bloodstream. The final device is intended to be a single wristwatch-style device containing a laser, a camera, and an alternating current (ac) electromagnet generated by a solenoid. The experiments presented are performed in vitro as proof of the concept. When a glucose substance is inserted into a solenoid generating an ac magnetic field, it exhibits Faraday rotation, which affects the temporal changes of the secondary speckle pattern distributions. The temporal frequency resulting from the ac magnetic field was found to have a lock-in amplification role, which increased the observability of the relatively small magneto-optic effect. Experimental results to support the proposed concept are presented. |
doi_str_mv | 10.1117/1.JBO.21.6.065001 |
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The final device is intended to be a single wristwatch-style device containing a laser, a camera, and an alternating current (ac) electromagnet generated by a solenoid. The experiments presented are performed in vitro as proof of the concept. When a glucose substance is inserted into a solenoid generating an ac magnetic field, it exhibits Faraday rotation, which affects the temporal changes of the secondary speckle pattern distributions. The temporal frequency resulting from the ac magnetic field was found to have a lock-in amplification role, which increased the observability of the relatively small magneto-optic effect. Experimental results to support the proposed concept are presented.</description><identifier>ISSN: 1083-3668</identifier><identifier>EISSN: 1560-2281</identifier><identifier>DOI: 10.1117/1.JBO.21.6.065001</identifier><identifier>PMID: 27251076</identifier><language>eng</language><publisher>United States: Society of Photo-Optical Instrumentation Engineers</publisher><subject>Blood Chemical Analysis - instrumentation ; Blood Chemical Analysis - methods ; Blood Glucose - analysis ; Humans ; Lasers ; Light ; Magnets ; Optics and Photonics ; Rotation</subject><ispartof>Journal of biomedical optics, 2016-06, Vol.21 (6), p.065001-065001</ispartof><rights>2016 Society of Photo-Optical Instrumentation Engineers (SPIE)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-b275007939578a314b4851044f4bd55641b3ff70dea5c849d87aa5faaf18c9de3</citedby><cites>FETCH-LOGICAL-c526t-b275007939578a314b4851044f4bd55641b3ff70dea5c849d87aa5faaf18c9de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27251076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozana, Nisan</creatorcontrib><creatorcontrib>Beiderman, Yevgeny</creatorcontrib><creatorcontrib>Anand, Arun</creatorcontrib><creatorcontrib>Javidi, Baharam</creatorcontrib><creatorcontrib>Polani, Sagi</creatorcontrib><creatorcontrib>Schwarz, Ariel</creatorcontrib><creatorcontrib>Shemer, Amir</creatorcontrib><creatorcontrib>Garcia, Javier</creatorcontrib><creatorcontrib>Zalevsky, Zeev</creatorcontrib><title>Noncontact speckle-based optical sensor for detection of glucose concentration using magneto-optic effect</title><title>Journal of biomedical optics</title><addtitle>J. Biomed. Opt</addtitle><description>We experimentally verify a speckle-based technique for noncontact measurement of glucose concentration in the bloodstream. The final device is intended to be a single wristwatch-style device containing a laser, a camera, and an alternating current (ac) electromagnet generated by a solenoid. The experiments presented are performed in vitro as proof of the concept. When a glucose substance is inserted into a solenoid generating an ac magnetic field, it exhibits Faraday rotation, which affects the temporal changes of the secondary speckle pattern distributions. The temporal frequency resulting from the ac magnetic field was found to have a lock-in amplification role, which increased the observability of the relatively small magneto-optic effect. Experimental results to support the proposed concept are presented.</description><subject>Blood Chemical Analysis - instrumentation</subject><subject>Blood Chemical Analysis - methods</subject><subject>Blood Glucose - analysis</subject><subject>Humans</subject><subject>Lasers</subject><subject>Light</subject><subject>Magnets</subject><subject>Optics and Photonics</subject><subject>Rotation</subject><issn>1083-3668</issn><issn>1560-2281</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtP3TAQha2Kimd_QDeVl2ySepLYcZY8Cm2FgAWsLccZX4Xm2sF2Fu2vr7mXUqnQxcgjzzmfZg4hH4GVANB-hvL76U1ZQSlKJjhj8I7sAxesqCoJO7lnsi5qIeQeOYjxgTEmRSd2yV7VVhxYK_bJeO2d8S5pk2ic0fyYsOh1xIH6OY1GTzSiiz5Qm2vAhCaN3lFv6WpajI9Is9ugS0FvBksc3Yqu9cph8sWGQdHabDsi762eIn54fg_J_cWXu7OvxdXN5bezk6vC8Eqkoq_afEnb1R1vpa6h6RuZd20a2_QD56KBvra2ZQNqbmTTDbLVmlutLUjTDVgfkuMtdw7-ccGY1HqMBqdJO_RLVPDEZp1kPEthKzXBxxjQqjmMax1-KmDqKWEFKiesKlBCbRPOnk_P-KVf4_Di-BNpFtxtBXEeUT34Jbh87l_Or3H-F7r5Owk5qwlvzy9ejefBZmz5Fvb_i_4GmBOh6g</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Ozana, Nisan</creator><creator>Beiderman, Yevgeny</creator><creator>Anand, Arun</creator><creator>Javidi, Baharam</creator><creator>Polani, Sagi</creator><creator>Schwarz, Ariel</creator><creator>Shemer, Amir</creator><creator>Garcia, Javier</creator><creator>Zalevsky, Zeev</creator><general>Society of Photo-Optical Instrumentation Engineers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160601</creationdate><title>Noncontact speckle-based optical sensor for detection of glucose concentration using magneto-optic effect</title><author>Ozana, Nisan ; Beiderman, Yevgeny ; Anand, Arun ; Javidi, Baharam ; Polani, Sagi ; Schwarz, Ariel ; Shemer, Amir ; Garcia, Javier ; Zalevsky, Zeev</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-b275007939578a314b4851044f4bd55641b3ff70dea5c849d87aa5faaf18c9de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Blood Chemical Analysis - instrumentation</topic><topic>Blood Chemical Analysis - methods</topic><topic>Blood Glucose - analysis</topic><topic>Humans</topic><topic>Lasers</topic><topic>Light</topic><topic>Magnets</topic><topic>Optics and Photonics</topic><topic>Rotation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozana, Nisan</creatorcontrib><creatorcontrib>Beiderman, Yevgeny</creatorcontrib><creatorcontrib>Anand, Arun</creatorcontrib><creatorcontrib>Javidi, Baharam</creatorcontrib><creatorcontrib>Polani, Sagi</creatorcontrib><creatorcontrib>Schwarz, Ariel</creatorcontrib><creatorcontrib>Shemer, Amir</creatorcontrib><creatorcontrib>Garcia, Javier</creatorcontrib><creatorcontrib>Zalevsky, Zeev</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozana, Nisan</au><au>Beiderman, Yevgeny</au><au>Anand, Arun</au><au>Javidi, Baharam</au><au>Polani, Sagi</au><au>Schwarz, Ariel</au><au>Shemer, Amir</au><au>Garcia, Javier</au><au>Zalevsky, Zeev</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noncontact speckle-based optical sensor for detection of glucose concentration using magneto-optic effect</atitle><jtitle>Journal of biomedical optics</jtitle><addtitle>J. Biomed. Opt</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>21</volume><issue>6</issue><spage>065001</spage><epage>065001</epage><pages>065001-065001</pages><issn>1083-3668</issn><eissn>1560-2281</eissn><abstract>We experimentally verify a speckle-based technique for noncontact measurement of glucose concentration in the bloodstream. The final device is intended to be a single wristwatch-style device containing a laser, a camera, and an alternating current (ac) electromagnet generated by a solenoid. The experiments presented are performed in vitro as proof of the concept. When a glucose substance is inserted into a solenoid generating an ac magnetic field, it exhibits Faraday rotation, which affects the temporal changes of the secondary speckle pattern distributions. The temporal frequency resulting from the ac magnetic field was found to have a lock-in amplification role, which increased the observability of the relatively small magneto-optic effect. Experimental results to support the proposed concept are presented.</abstract><cop>United States</cop><pub>Society of Photo-Optical Instrumentation Engineers</pub><pmid>27251076</pmid><doi>10.1117/1.JBO.21.6.065001</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
subjects | Blood Chemical Analysis - instrumentation Blood Chemical Analysis - methods Blood Glucose - analysis Humans Lasers Light Magnets Optics and Photonics Rotation |
title | Noncontact speckle-based optical sensor for detection of glucose concentration using magneto-optic effect |
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