Melphalan 200 mg/m 2 in patients with renal impairment is associated with increased short-term toxicity but improved response and longer treatment-free survival

Melphalan 200 mg/m 2 in patients with renal impairment is associated with increased short-term toxicity but improved response and longer treatment-free survival

Data on the effectiveness and toxicity of high-dose melphalan in patients with renal impairment (RI) are lacking. We evaluated the impact of RI on outcomes of patients with multiple myeloma treated with melphalan 200 mg/m (Mel200) and autologous stem cell transplantation. Similar baseline characteri...

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Veröffentlicht in:Bone marrow transplantation (Basingstoke) 2016-10, Vol.51 (10), p.1337
Hauptverfasser: Sweiss, K, Patel, S, Culos, K, Oh, A, Rondelli, D, Patel, P
Format: Artikel
Sprache:eng
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Zusammenfassung:Data on the effectiveness and toxicity of high-dose melphalan in patients with renal impairment (RI) are lacking. We evaluated the impact of RI on outcomes of patients with multiple myeloma treated with melphalan 200 mg/m (Mel200) and autologous stem cell transplantation. Similar baseline characteristics were seen among 46 patients with creatinine clearance (CrCl)
ISSN:1476-5365
DOI:10.1038/bmt.2016.136