Protective effect of Pycnogenol on cisplatin-induced ototoxicity in rats

Context: Pycnogenol ® , which is French maritime pine bark extract, is a potent antioxidant. It is used in medical conditions caused by oxidative stress. Cisplatin (cis-diamminedichloroplatinum II) is an antineoplastic agent. However, its serious side effects such as ototoxicity limit its usage. Obj...

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Veröffentlicht in:	Pharmaceutical biology 2016-11, Vol.54 (11), p.2777-2781
Hauptverfasser:	Eryilmaz, Aylin, Eliyatkin, Nuket, Demirci, Buket, Basal, Yesim, Kurt Omurlu, Imran, Gunel, Ceren, Aktas, Safiye, Toka, Ali, Basak, Sema
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - toxicity Antineoplastics antioxidants Cisplatin - toxicity Cochlea - drug effects Cochlea - physiology cochlear apoptosis Flavonoids - pharmacology Male Organ of Corti - drug effects Otoacoustic Emissions, Spontaneous - drug effects Rats Spiral Ganglion - drug effects
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