Enhanced nanocurcumin toxicity against (PC3) tumor and microbial by using magnetic field in vitro
Curcumin is more soluble in ethanol, dimethylsulfoxide, methanol and acetone than in water. In this study, nanocurcumin combined with 8 mT AC static magnetic field was used to enhance cellular uptake, bioavailability, and ultimate efficiency of curcumin against prostate cancer cell line (PC3), four...
Gespeichert in:
| Veröffentlicht in: | Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2017-06, Vol.45 (4), p.843-853 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 853 |
|---|---|
| container_issue | 4 |
| container_start_page | 843 |
| container_title | Artificial cells, nanomedicine, and biotechnology |
| container_volume | 45 |
| creator | Aldahoun, Mo'ath Ahmad Jaafar, M. S. Al-Akhras, M-Ali H. Bououdina, M. |
| description | Curcumin is more soluble in ethanol, dimethylsulfoxide, methanol and acetone than in water. In this study, nanocurcumin combined with 8 mT AC static magnetic field was used to enhance cellular uptake, bioavailability, and ultimate efficiency of curcumin against prostate cancer cell line (PC3), four bacteria strains (two Gram positive: Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 29213 and two Gram negative: Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), mammalian cell line (HEK) and human erythrocytes (RBC). The efficiency (E%) between IC
50
of nanocurcumin combined with magnetic field (NANOCUR-MF) and control against PC3 was 35.93%, which is three times higher compared to curcumin combined with magnetic field (CUR-MF); i.e., 10.77%. However, their E% against HEK was not significant; 1.4% for NANOCUR-MF and 1.95% for CUR-MF. Moreover, depending in minimum bacterial concentration (MBC), the use of MF leads to a reduction of MBCs for all tested bacteria compared with control. The obtained results established the applicability of (MF) in enhancing cellular uptake for PC3 and tested bacteria strains by increasing the penetration of drug (nanocurcumin and parent curcumin) into cell with fixing mild cytotoxic profile for HEK and RBC. |
| doi_str_mv | 10.1080/21691401.2016.1178137 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_27137748</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4321325031</sourcerecordid><originalsourceid>FETCH-LOGICAL-c427t-5f8d5e56ab80ba1b92fc03dc87a8b87b6d8ae6489975521bc51d1bc3fc57d9e13</originalsourceid><addsrcrecordid>eNp9kc1PHCEYh0ljU436J7Qh6cUeduWdGQa4aTZ-JSbtQZPeCF-zxcyABcZ2__uy2dWDh3IAQp739wIPQp-BLIFwct5AL6AjsGwI9EsAxqFlH9DR9nwBHfw8eNsTOESnOT-ROjj0jHaf0GHDKs86foTUVfilgnEWBxWimZOZJx9wiX-98WWD1Vr5kAs--7Fqv-EyTzFhFSyevElRezVivcFz9mGNJ7UOrniDB-9Gi2vKiy8pnqCPgxqzO92vx-jx-uphdbu4_35zt7q8X5iuYWVBB26po73SnGgFWjSDIa01nCmuOdO95cr1HReCUdqANhRsndvBUGaFg_YYne1yn1P8Pbtc5OSzceOogotzliAIsLYXpK_o13foU5xTqLeTwHnTMSpEUym6o-pLc05ukM_JTyptJBC51SBfNcitBrnXUOu-7NNnPTn7VvX66RW42AE-DDFN6k9Mo5VFbcaYhlRt-Czb__f4B370liw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1882475992</pqid></control><display><type>article</type><title>Enhanced nanocurcumin toxicity against (PC3) tumor and microbial by using magnetic field in vitro</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Aldahoun, Mo'ath Ahmad ; Jaafar, M. S. ; Al-Akhras, M-Ali H. ; Bououdina, M.</creator><creatorcontrib>Aldahoun, Mo'ath Ahmad ; Jaafar, M. S. ; Al-Akhras, M-Ali H. ; Bououdina, M.</creatorcontrib><description>Curcumin is more soluble in ethanol, dimethylsulfoxide, methanol and acetone than in water. In this study, nanocurcumin combined with 8 mT AC static magnetic field was used to enhance cellular uptake, bioavailability, and ultimate efficiency of curcumin against prostate cancer cell line (PC3), four bacteria strains (two Gram positive: Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 29213 and two Gram negative: Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), mammalian cell line (HEK) and human erythrocytes (RBC). The efficiency (E%) between IC
50
of nanocurcumin combined with magnetic field (NANOCUR-MF) and control against PC3 was 35.93%, which is three times higher compared to curcumin combined with magnetic field (CUR-MF); i.e., 10.77%. However, their E% against HEK was not significant; 1.4% for NANOCUR-MF and 1.95% for CUR-MF. Moreover, depending in minimum bacterial concentration (MBC), the use of MF leads to a reduction of MBCs for all tested bacteria compared with control. The obtained results established the applicability of (MF) in enhancing cellular uptake for PC3 and tested bacteria strains by increasing the penetration of drug (nanocurcumin and parent curcumin) into cell with fixing mild cytotoxic profile for HEK and RBC.</description><identifier>ISSN: 2169-1401</identifier><identifier>EISSN: 2169-141X</identifier><identifier>DOI: 10.1080/21691401.2016.1178137</identifier><identifier>PMID: 27137748</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Acetone ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - metabolism ; Anti-Bacterial Agents - pharmacokinetics ; Anti-Bacterial Agents - pharmacology ; Anticancer ; antimicrobial ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - metabolism ; Antineoplastic Agents - pharmacokinetics ; Antineoplastic Agents - pharmacology ; Bacteria ; Bacteria - drug effects ; Bioavailability ; Biological Availability ; Biological Transport ; Cell Line, Tumor ; Cell Membrane Permeability ; Curcumin ; Curcumin - chemistry ; Curcumin - metabolism ; Curcumin - pharmacokinetics ; Curcumin - pharmacology ; Cytotoxicity ; drug delivery ; E coli ; Erythrocytes ; Erythrocytes - drug effects ; Escherichia coli ; Ethanol ; Humans ; magnetic field ; Magnetic Fields ; Male ; membrane-permeation ; Micrococcus luteus ; Microorganisms ; nanocurcumin ; Nanoparticles - chemistry ; Prostate cancer ; Prostatic Neoplasms - pathology ; Pseudomonas aeruginosa ; Staphylococcus aureus ; Strains (organisms) ; Toxicity</subject><ispartof>Artificial cells, nanomedicine, and biotechnology, 2017-06, Vol.45 (4), p.843-853</ispartof><rights>2016 Informa UK Limited, trading as Taylor & Francis Group 2016</rights><rights>2016 Informa UK Limited, trading as Taylor & Francis Group</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-5f8d5e56ab80ba1b92fc03dc87a8b87b6d8ae6489975521bc51d1bc3fc57d9e13</citedby><cites>FETCH-LOGICAL-c427t-5f8d5e56ab80ba1b92fc03dc87a8b87b6d8ae6489975521bc51d1bc3fc57d9e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27137748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aldahoun, Mo'ath Ahmad</creatorcontrib><creatorcontrib>Jaafar, M. S.</creatorcontrib><creatorcontrib>Al-Akhras, M-Ali H.</creatorcontrib><creatorcontrib>Bououdina, M.</creatorcontrib><title>Enhanced nanocurcumin toxicity against (PC3) tumor and microbial by using magnetic field in vitro</title><title>Artificial cells, nanomedicine, and biotechnology</title><addtitle>Artif Cells Nanomed Biotechnol</addtitle><description>Curcumin is more soluble in ethanol, dimethylsulfoxide, methanol and acetone than in water. In this study, nanocurcumin combined with 8 mT AC static magnetic field was used to enhance cellular uptake, bioavailability, and ultimate efficiency of curcumin against prostate cancer cell line (PC3), four bacteria strains (two Gram positive: Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 29213 and two Gram negative: Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), mammalian cell line (HEK) and human erythrocytes (RBC). The efficiency (E%) between IC
50
of nanocurcumin combined with magnetic field (NANOCUR-MF) and control against PC3 was 35.93%, which is three times higher compared to curcumin combined with magnetic field (CUR-MF); i.e., 10.77%. However, their E% against HEK was not significant; 1.4% for NANOCUR-MF and 1.95% for CUR-MF. Moreover, depending in minimum bacterial concentration (MBC), the use of MF leads to a reduction of MBCs for all tested bacteria compared with control. The obtained results established the applicability of (MF) in enhancing cellular uptake for PC3 and tested bacteria strains by increasing the penetration of drug (nanocurcumin and parent curcumin) into cell with fixing mild cytotoxic profile for HEK and RBC.</description><subject>Acetone</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - metabolism</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anticancer</subject><subject>antimicrobial</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - metabolism</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Bacteria</subject><subject>Bacteria - drug effects</subject><subject>Bioavailability</subject><subject>Biological Availability</subject><subject>Biological Transport</subject><subject>Cell Line, Tumor</subject><subject>Cell Membrane Permeability</subject><subject>Curcumin</subject><subject>Curcumin - chemistry</subject><subject>Curcumin - metabolism</subject><subject>Curcumin - pharmacokinetics</subject><subject>Curcumin - pharmacology</subject><subject>Cytotoxicity</subject><subject>drug delivery</subject><subject>E coli</subject><subject>Erythrocytes</subject><subject>Erythrocytes - drug effects</subject><subject>Escherichia coli</subject><subject>Ethanol</subject><subject>Humans</subject><subject>magnetic field</subject><subject>Magnetic Fields</subject><subject>Male</subject><subject>membrane-permeation</subject><subject>Micrococcus luteus</subject><subject>Microorganisms</subject><subject>nanocurcumin</subject><subject>Nanoparticles - chemistry</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Pseudomonas aeruginosa</subject><subject>Staphylococcus aureus</subject><subject>Strains (organisms)</subject><subject>Toxicity</subject><issn>2169-1401</issn><issn>2169-141X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1PHCEYh0ljU436J7Qh6cUeduWdGQa4aTZ-JSbtQZPeCF-zxcyABcZ2__uy2dWDh3IAQp739wIPQp-BLIFwct5AL6AjsGwI9EsAxqFlH9DR9nwBHfw8eNsTOESnOT-ROjj0jHaf0GHDKs86foTUVfilgnEWBxWimZOZJx9wiX-98WWD1Vr5kAs--7Fqv-EyTzFhFSyevElRezVivcFz9mGNJ7UOrniDB-9Gi2vKiy8pnqCPgxqzO92vx-jx-uphdbu4_35zt7q8X5iuYWVBB26po73SnGgFWjSDIa01nCmuOdO95cr1HReCUdqANhRsndvBUGaFg_YYne1yn1P8Pbtc5OSzceOogotzliAIsLYXpK_o13foU5xTqLeTwHnTMSpEUym6o-pLc05ukM_JTyptJBC51SBfNcitBrnXUOu-7NNnPTn7VvX66RW42AE-DDFN6k9Mo5VFbcaYhlRt-Czb__f4B370liw</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Aldahoun, Mo'ath Ahmad</creator><creator>Jaafar, M. S.</creator><creator>Al-Akhras, M-Ali H.</creator><creator>Bououdina, M.</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20170601</creationdate><title>Enhanced nanocurcumin toxicity against (PC3) tumor and microbial by using magnetic field in vitro</title><author>Aldahoun, Mo'ath Ahmad ; Jaafar, M. S. ; Al-Akhras, M-Ali H. ; Bououdina, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-5f8d5e56ab80ba1b92fc03dc87a8b87b6d8ae6489975521bc51d1bc3fc57d9e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acetone</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - metabolism</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anticancer</topic><topic>antimicrobial</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - metabolism</topic><topic>Antineoplastic Agents - pharmacokinetics</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Bacteria</topic><topic>Bacteria - drug effects</topic><topic>Bioavailability</topic><topic>Biological Availability</topic><topic>Biological Transport</topic><topic>Cell Line, Tumor</topic><topic>Cell Membrane Permeability</topic><topic>Curcumin</topic><topic>Curcumin - chemistry</topic><topic>Curcumin - metabolism</topic><topic>Curcumin - pharmacokinetics</topic><topic>Curcumin - pharmacology</topic><topic>Cytotoxicity</topic><topic>drug delivery</topic><topic>E coli</topic><topic>Erythrocytes</topic><topic>Erythrocytes - drug effects</topic><topic>Escherichia coli</topic><topic>Ethanol</topic><topic>Humans</topic><topic>magnetic field</topic><topic>Magnetic Fields</topic><topic>Male</topic><topic>membrane-permeation</topic><topic>Micrococcus luteus</topic><topic>Microorganisms</topic><topic>nanocurcumin</topic><topic>Nanoparticles - chemistry</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Pseudomonas aeruginosa</topic><topic>Staphylococcus aureus</topic><topic>Strains (organisms)</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aldahoun, Mo'ath Ahmad</creatorcontrib><creatorcontrib>Jaafar, M. S.</creatorcontrib><creatorcontrib>Al-Akhras, M-Ali H.</creatorcontrib><creatorcontrib>Bououdina, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aldahoun, Mo'ath Ahmad</au><au>Jaafar, M. S.</au><au>Al-Akhras, M-Ali H.</au><au>Bououdina, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced nanocurcumin toxicity against (PC3) tumor and microbial by using magnetic field in vitro</atitle><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle><addtitle>Artif Cells Nanomed Biotechnol</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>45</volume><issue>4</issue><spage>843</spage><epage>853</epage><pages>843-853</pages><issn>2169-1401</issn><eissn>2169-141X</eissn><abstract>Curcumin is more soluble in ethanol, dimethylsulfoxide, methanol and acetone than in water. In this study, nanocurcumin combined with 8 mT AC static magnetic field was used to enhance cellular uptake, bioavailability, and ultimate efficiency of curcumin against prostate cancer cell line (PC3), four bacteria strains (two Gram positive: Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 29213 and two Gram negative: Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), mammalian cell line (HEK) and human erythrocytes (RBC). The efficiency (E%) between IC
50
of nanocurcumin combined with magnetic field (NANOCUR-MF) and control against PC3 was 35.93%, which is three times higher compared to curcumin combined with magnetic field (CUR-MF); i.e., 10.77%. However, their E% against HEK was not significant; 1.4% for NANOCUR-MF and 1.95% for CUR-MF. Moreover, depending in minimum bacterial concentration (MBC), the use of MF leads to a reduction of MBCs for all tested bacteria compared with control. The obtained results established the applicability of (MF) in enhancing cellular uptake for PC3 and tested bacteria strains by increasing the penetration of drug (nanocurcumin and parent curcumin) into cell with fixing mild cytotoxic profile for HEK and RBC.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>27137748</pmid><doi>10.1080/21691401.2016.1178137</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2169-1401 |
| ispartof | Artificial cells, nanomedicine, and biotechnology, 2017-06, Vol.45 (4), p.843-853 |
| issn | 2169-1401 2169-141X |
| language | eng |
| recordid | cdi_pubmed_primary_27137748 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Acetone Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Anticancer antimicrobial Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Bacteria Bacteria - drug effects Bioavailability Biological Availability Biological Transport Cell Line, Tumor Cell Membrane Permeability Curcumin Curcumin - chemistry Curcumin - metabolism Curcumin - pharmacokinetics Curcumin - pharmacology Cytotoxicity drug delivery E coli Erythrocytes Erythrocytes - drug effects Escherichia coli Ethanol Humans magnetic field Magnetic Fields Male membrane-permeation Micrococcus luteus Microorganisms nanocurcumin Nanoparticles - chemistry Prostate cancer Prostatic Neoplasms - pathology Pseudomonas aeruginosa Staphylococcus aureus Strains (organisms) Toxicity |
| title | Enhanced nanocurcumin toxicity against (PC3) tumor and microbial by using magnetic field in vitro |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T03%3A12%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Enhanced%20nanocurcumin%20toxicity%20against%20(PC3)%20tumor%20and%20microbial%20by%20using%20magnetic%20field%20in%20vitro&rft.jtitle=Artificial%20cells,%20nanomedicine,%20and%20biotechnology&rft.au=Aldahoun,%20Mo'ath%20Ahmad&rft.date=2017-06-01&rft.volume=45&rft.issue=4&rft.spage=843&rft.epage=853&rft.pages=843-853&rft.issn=2169-1401&rft.eissn=2169-141X&rft_id=info:doi/10.1080/21691401.2016.1178137&rft_dat=%3Cproquest_pubme%3E4321325031%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1882475992&rft_id=info:pmid/27137748&rfr_iscdi=true |