Biochemical Adaptations in a Slow and a Fast Plantarflexor Muscle of Rats Housed in Small Cages
BACKGROUND: Chronic unloading and restricted activity are distinctly different processes, i.e., unloading completely removes the load on postural muscles, whereas restricted activity allows for loading of postural muscles. There are limited data available on the effects of restricted activity on ske...
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| Veröffentlicht in: | Aerospace medicine and human performance 2016-05, Vol.87 (5), p.443-448 |
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| creator | Takemura, Ai Roy, Roland R. Edgerton, V. Reggie Ishihara, Akihiko |
| description | BACKGROUND: Chronic unloading and restricted activity are distinctly different processes, i.e., unloading completely removes the load on postural muscles, whereas restricted activity allows for loading of postural muscles. There are limited data available on the effects of restricted
activity on skeletal muscles. Thus the effects of restricted activity on the properties of the slow soleus and fast plantaris muscles in rats were examined.METHODS: Eight-week-old rats were housed for 21 d in normal-sized (control group) or in small-sized (restricted group) cages.RESULTS:
Decreased mRNA levels of peroxisome proliferator-activated receptor γ coactivator-1α (81 and 85% of control values) and reduced succinate dehydrogenase activity (85 and 88% of control values) were observed in the soleus and the plantaris muscles of the restricted group, respectively.
Increased mRNA levels of forkhead box-containing protein O1 (128% of control values), decreased muscle weight (74% of control values), and reduced cross-sectional areas of type IIA (89% of control values) and type IIB (80% of control values) fibers were observed in the plantaris muscle of
the restricted group.DISCUSSION: Restricted activity decreased the mRNA levels of peroxisome proliferator-activated receptor γ coactivator-1α and increased the mRNA levels of forkhead box-containing protein O1, which are associated with reduced oxidative capacity and
atrophy, respectively, in the muscles. The plantaris muscle was more affected by restricted activity than the soleus muscle, most likely reflecting a greater relative change in the normal activity pattern in the fast than slow plantarflexor muscle.Takemura A, Roy RR, Edgerton VR, Ishihara
A. Biochemical adaptations in a slow and a fast plantarflexor muscle of rats housed in small cages. Aerosp Med Hum Perform. 2016; 87(5):443-448. |
| doi_str_mv | 10.3357/AMHP.4436.2016 |
| format | Article |
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activity on skeletal muscles. Thus the effects of restricted activity on the properties of the slow soleus and fast plantaris muscles in rats were examined.METHODS: Eight-week-old rats were housed for 21 d in normal-sized (control group) or in small-sized (restricted group) cages.RESULTS:
Decreased mRNA levels of peroxisome proliferator-activated receptor γ coactivator-1α (81 and 85% of control values) and reduced succinate dehydrogenase activity (85 and 88% of control values) were observed in the soleus and the plantaris muscles of the restricted group, respectively.
Increased mRNA levels of forkhead box-containing protein O1 (128% of control values), decreased muscle weight (74% of control values), and reduced cross-sectional areas of type IIA (89% of control values) and type IIB (80% of control values) fibers were observed in the plantaris muscle of
the restricted group.DISCUSSION: Restricted activity decreased the mRNA levels of peroxisome proliferator-activated receptor γ coactivator-1α and increased the mRNA levels of forkhead box-containing protein O1, which are associated with reduced oxidative capacity and
atrophy, respectively, in the muscles. The plantaris muscle was more affected by restricted activity than the soleus muscle, most likely reflecting a greater relative change in the normal activity pattern in the fast than slow plantarflexor muscle.Takemura A, Roy RR, Edgerton VR, Ishihara
A. Biochemical adaptations in a slow and a fast plantarflexor muscle of rats housed in small cages. Aerosp Med Hum Perform. 2016; 87(5):443-448.</description><identifier>ISSN: 2375-6314</identifier><identifier>EISSN: 2375-6322</identifier><identifier>DOI: 10.3357/AMHP.4436.2016</identifier><identifier>PMID: 27099082</identifier><language>eng</language><publisher>United States: Aerospace Medical Association</publisher><subject>Adaptation ; Adaptation, Physiological ; Animals ; Biochemistry ; Cages ; Confined Spaces ; Cross sections ; Forkhead Transcription Factors - genetics ; Forkhead Transcription Factors - metabolism ; Foxo1 ; Housing, Animal ; Male ; Muscle Fiber ; Muscle Fibers, Fast-Twitch - metabolism ; Muscle, Skeletal - metabolism ; Muscles ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Oxidative Capacity ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Pgc-1α ; Proteins ; Rats ; Rats, Wistar ; Receptors ; Restricted Activity ; RNA, Messenger - metabolism ; Space life sciences ; Succinate Dehydrogenase - genetics ; Succinate Dehydrogenase - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Aerospace medicine and human performance, 2016-05, Vol.87 (5), p.443-448</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-16f88145e40d85f402692ed7bf2ebb83789535d591a977265716231c4a1318a73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27099082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takemura, Ai</creatorcontrib><creatorcontrib>Roy, Roland R.</creatorcontrib><creatorcontrib>Edgerton, V. Reggie</creatorcontrib><creatorcontrib>Ishihara, Akihiko</creatorcontrib><title>Biochemical Adaptations in a Slow and a Fast Plantarflexor Muscle of Rats Housed in Small Cages</title><title>Aerospace medicine and human performance</title><addtitle>Aerosp Med Hum Perform</addtitle><description>BACKGROUND: Chronic unloading and restricted activity are distinctly different processes, i.e., unloading completely removes the load on postural muscles, whereas restricted activity allows for loading of postural muscles. There are limited data available on the effects of restricted
activity on skeletal muscles. Thus the effects of restricted activity on the properties of the slow soleus and fast plantaris muscles in rats were examined.METHODS: Eight-week-old rats were housed for 21 d in normal-sized (control group) or in small-sized (restricted group) cages.RESULTS:
Decreased mRNA levels of peroxisome proliferator-activated receptor γ coactivator-1α (81 and 85% of control values) and reduced succinate dehydrogenase activity (85 and 88% of control values) were observed in the soleus and the plantaris muscles of the restricted group, respectively.
Increased mRNA levels of forkhead box-containing protein O1 (128% of control values), decreased muscle weight (74% of control values), and reduced cross-sectional areas of type IIA (89% of control values) and type IIB (80% of control values) fibers were observed in the plantaris muscle of
the restricted group.DISCUSSION: Restricted activity decreased the mRNA levels of peroxisome proliferator-activated receptor γ coactivator-1α and increased the mRNA levels of forkhead box-containing protein O1, which are associated with reduced oxidative capacity and
atrophy, respectively, in the muscles. The plantaris muscle was more affected by restricted activity than the soleus muscle, most likely reflecting a greater relative change in the normal activity pattern in the fast than slow plantarflexor muscle.Takemura A, Roy RR, Edgerton VR, Ishihara
A. Biochemical adaptations in a slow and a fast plantarflexor muscle of rats housed in small cages. Aerosp Med Hum Perform. 2016; 87(5):443-448.</description><subject>Adaptation</subject><subject>Adaptation, Physiological</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Cages</subject><subject>Confined Spaces</subject><subject>Cross sections</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>Forkhead Transcription Factors - metabolism</subject><subject>Foxo1</subject><subject>Housing, Animal</subject><subject>Male</subject><subject>Muscle Fiber</subject><subject>Muscle Fibers, Fast-Twitch - metabolism</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscles</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Oxidative Capacity</subject><subject>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha</subject><subject>Pgc-1α</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors</subject><subject>Restricted Activity</subject><subject>RNA, Messenger - metabolism</subject><subject>Space life sciences</subject><subject>Succinate Dehydrogenase - genetics</subject><subject>Succinate Dehydrogenase - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>2375-6314</issn><issn>2375-6322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1v1DAQxSMEolXplSPykcsuHn_E9nFZURaphYrCeTSbONtUTrLYSfn463G6S29I9WXe4c3Po3lTFK-BL6XU5t3qanO9VEqWS8GhfFacCmn0opRCPH_UoE6K85TuOOegAITWL4sTYbhz3IrTAt-3Q3Xru7aiwFY17Uca26FPrO0ZsZsw_GTU11leUBrZdaB-pNgE_2uI7GpKVfBsaNhXGhPbDFPy9dx401EIbE07n14VLxoKyZ8f61nx_eLDt_Vmcfnl46f16nJRaV2OCygba0Fpr3htdaO4KJ3wtdk2wm-3VhrrtNS1dkDOGFFqA6WQUCkCCZaMPCveHrj7OPyYfBqxa1PlQx7Y57kQLGjn8l9PsBqnlNOW8ydYrXSCS9DZujxYqzikFH2D-9h2FH8jcJzTwjktnNPCOa3c8ObInradrx_t_7LJhtXB0PY7n9eOd8MU-7xEpNQRUne7fyAhf3jWHAXXSHGchcqMz_9htNUBM5_JfCV4b02vM1AAt-Awnwpg7Ruawog5c9z9waTkX31vunU</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Takemura, Ai</creator><creator>Roy, Roland R.</creator><creator>Edgerton, V. Reggie</creator><creator>Ishihara, Akihiko</creator><general>Aerospace Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20160501</creationdate><title>Biochemical Adaptations in a Slow and a Fast Plantarflexor Muscle of Rats Housed in Small Cages</title><author>Takemura, Ai ; Roy, Roland R. ; Edgerton, V. Reggie ; Ishihara, Akihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-16f88145e40d85f402692ed7bf2ebb83789535d591a977265716231c4a1318a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adaptation</topic><topic>Adaptation, Physiological</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Cages</topic><topic>Confined Spaces</topic><topic>Cross sections</topic><topic>Forkhead Transcription Factors - genetics</topic><topic>Forkhead Transcription Factors - metabolism</topic><topic>Foxo1</topic><topic>Housing, Animal</topic><topic>Male</topic><topic>Muscle Fiber</topic><topic>Muscle Fibers, Fast-Twitch - metabolism</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscles</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Oxidative Capacity</topic><topic>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha</topic><topic>Pgc-1α</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors</topic><topic>Restricted Activity</topic><topic>RNA, Messenger - metabolism</topic><topic>Space life sciences</topic><topic>Succinate Dehydrogenase - genetics</topic><topic>Succinate Dehydrogenase - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takemura, Ai</creatorcontrib><creatorcontrib>Roy, Roland R.</creatorcontrib><creatorcontrib>Edgerton, V. Reggie</creatorcontrib><creatorcontrib>Ishihara, Akihiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Aerospace medicine and human performance</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takemura, Ai</au><au>Roy, Roland R.</au><au>Edgerton, V. Reggie</au><au>Ishihara, Akihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biochemical Adaptations in a Slow and a Fast Plantarflexor Muscle of Rats Housed in Small Cages</atitle><jtitle>Aerospace medicine and human performance</jtitle><addtitle>Aerosp Med Hum Perform</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>87</volume><issue>5</issue><spage>443</spage><epage>448</epage><pages>443-448</pages><issn>2375-6314</issn><eissn>2375-6322</eissn><abstract>BACKGROUND: Chronic unloading and restricted activity are distinctly different processes, i.e., unloading completely removes the load on postural muscles, whereas restricted activity allows for loading of postural muscles. There are limited data available on the effects of restricted
activity on skeletal muscles. Thus the effects of restricted activity on the properties of the slow soleus and fast plantaris muscles in rats were examined.METHODS: Eight-week-old rats were housed for 21 d in normal-sized (control group) or in small-sized (restricted group) cages.RESULTS:
Decreased mRNA levels of peroxisome proliferator-activated receptor γ coactivator-1α (81 and 85% of control values) and reduced succinate dehydrogenase activity (85 and 88% of control values) were observed in the soleus and the plantaris muscles of the restricted group, respectively.
Increased mRNA levels of forkhead box-containing protein O1 (128% of control values), decreased muscle weight (74% of control values), and reduced cross-sectional areas of type IIA (89% of control values) and type IIB (80% of control values) fibers were observed in the plantaris muscle of
the restricted group.DISCUSSION: Restricted activity decreased the mRNA levels of peroxisome proliferator-activated receptor γ coactivator-1α and increased the mRNA levels of forkhead box-containing protein O1, which are associated with reduced oxidative capacity and
atrophy, respectively, in the muscles. The plantaris muscle was more affected by restricted activity than the soleus muscle, most likely reflecting a greater relative change in the normal activity pattern in the fast than slow plantarflexor muscle.Takemura A, Roy RR, Edgerton VR, Ishihara
A. Biochemical adaptations in a slow and a fast plantarflexor muscle of rats housed in small cages. Aerosp Med Hum Perform. 2016; 87(5):443-448.</abstract><cop>United States</cop><pub>Aerospace Medical Association</pub><pmid>27099082</pmid><doi>10.3357/AMHP.4436.2016</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adaptation Adaptation, Physiological Animals Biochemistry Cages Confined Spaces Cross sections Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Foxo1 Housing, Animal Male Muscle Fiber Muscle Fibers, Fast-Twitch - metabolism Muscle, Skeletal - metabolism Muscles Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Oxidative Capacity Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Pgc-1α Proteins Rats Rats, Wistar Receptors Restricted Activity RNA, Messenger - metabolism Space life sciences Succinate Dehydrogenase - genetics Succinate Dehydrogenase - metabolism Transcription Factors - genetics Transcription Factors - metabolism |
| title | Biochemical Adaptations in a Slow and a Fast Plantarflexor Muscle of Rats Housed in Small Cages |
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