New enolate-carbodiimide rearrangement in the concise synthesis of 6-amino-2,3-dihydro-4-pyridinones from homoallylamines

Three-step synthesis of 6-amino-2,3-dihydro-4-pyridinones from homoallylamines involving NBS-mediated cyclization of N -(3-butenyl)ureas to 6-(bromomethyl)-2-iminourethanes, dehydrohalogenation and a novel rearrangement as a key step has been developed. The scope and limitations of the method, as we...

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Veröffentlicht in:	Organic & biomolecular chemistry 2016-05, Vol.14 (18), p.4283-4298
Hauptverfasser:	Kuznetsov, N. Yu, Tikhov, R. M, Godovikov, I. A, Khrustalev, V. N, Bubnov, Yu. N
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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