Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Selective autophagy of damaged mitochondria requires autophagy receptors optineurin (OPTN), NDP52 (CALCOCO2), TAX1BP1, and p62 (SQSTM1) linking ubiquitinated cargo to autophagic membranes. By using quantitative proteomics, we show that Tank-binding kinase 1 (TBK1) phosphorylates all four receptors o...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-04, Vol.113 (15), p.4039-4044
Hauptverfasser:	Richter, Benjamin, Sliter, Danielle A., Herhaus, Lina, Stolz, Alexandra, Wang, Chunxin, Beli, Petra, Zaffagnini, Gabriele, Wild, Philipp, Martens, Sascha, Wagner, Sebastian A., Youle, Richard J., Dikic, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Biological Sciences HeLa Cells Humans Membranes Mitochondria Mitochondria - metabolism Phosphorylation Protein Binding Protein-Serine-Threonine Kinases - metabolism Proteomics Transcription Factor TFIIIA - metabolism Ubiquitin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!