Benzimidazolium-based novel silver N-heterocyclic carbene complexes: synthesis, characterisation and in vitro antimicrobial activity
This study reports the synthesis, characterisation and antimicrobial activity of five novel silver N-heterocyclic carbene (Ag-NHC) complexes obtained by N-propylphthalimide and N-methyldioxane substituted benzimidazolium salts with silver oxide. The reactions were performed at room temperature for 2...
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| Veröffentlicht in: | Journal of enzyme inhibition and medicinal chemistry 2016-11, Vol.31 (6), p.1527-1530 |
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| container_title | Journal of enzyme inhibition and medicinal chemistry |
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| creator | Sarı, Yakup Akkoç, Senem Gök, Yetkin Sifniotis, Vicki Özdemir, İlknur Günal, Selami Kayser, Veysel |
| description | This study reports the synthesis, characterisation and antimicrobial activity of five novel silver N-heterocyclic carbene (Ag-NHC) complexes obtained by N-propylphthalimide and N-methyldioxane substituted benzimidazolium salts with silver oxide. The reactions were performed at room temperature for 24 h in the absence of light. The obtained complexes were identified and characterised by
1
H and
13
C NMR, FT-IR and elemental analysis techniques. The minimum inhibitory concentration (MIC) of the complexes was determined for E. coli, P. aeruginosa, E. faecalis, S. aureus, C. tropicalis and C. albicans in vitro through agar and broth dilution. The results indicated that these complexes exhibit antimicrobial activity. In particular, complex 3 presented the significant broad spectrum antimicrobial activity. |
| doi_str_mv | 10.3109/14756366.2016.1156102 |
| format | Article |
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1
H and
13
C NMR, FT-IR and elemental analysis techniques. The minimum inhibitory concentration (MIC) of the complexes was determined for E. coli, P. aeruginosa, E. faecalis, S. aureus, C. tropicalis and C. albicans in vitro through agar and broth dilution. The results indicated that these complexes exhibit antimicrobial activity. In particular, complex 3 presented the significant broad spectrum antimicrobial activity.</description><identifier>ISSN: 1475-6366</identifier><identifier>EISSN: 1475-6374</identifier><identifier>DOI: 10.3109/14756366.2016.1156102</identifier><identifier>PMID: 26987046</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Anti-Infective Agents - chemical synthesis ; Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Antimicrobial activity ; benzimidazole ; Benzimidazoles - chemistry ; Carbon-13 Magnetic Resonance Spectroscopy ; Methane - analogs & derivatives ; Methane - chemical synthesis ; Methane - chemistry ; Methane - pharmacology ; Microbial Sensitivity Tests ; N-heterocyclic carbene ; Proton Magnetic Resonance Spectroscopy ; Silver - chemistry ; silver complex</subject><ispartof>Journal of enzyme inhibition and medicinal chemistry, 2016-11, Vol.31 (6), p.1527-1530</ispartof><rights>2016 Informa UK Limited, trading as Taylor & Francis Group 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-95aa8019018bfcb21a0af16b7fe6fb55361e5a07b941092b8ad89a3d02ecdc513</citedby><cites>FETCH-LOGICAL-c413t-95aa8019018bfcb21a0af16b7fe6fb55361e5a07b941092b8ad89a3d02ecdc513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26987046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sarı, Yakup</creatorcontrib><creatorcontrib>Akkoç, Senem</creatorcontrib><creatorcontrib>Gök, Yetkin</creatorcontrib><creatorcontrib>Sifniotis, Vicki</creatorcontrib><creatorcontrib>Özdemir, İlknur</creatorcontrib><creatorcontrib>Günal, Selami</creatorcontrib><creatorcontrib>Kayser, Veysel</creatorcontrib><title>Benzimidazolium-based novel silver N-heterocyclic carbene complexes: synthesis, characterisation and in vitro antimicrobial activity</title><title>Journal of enzyme inhibition and medicinal chemistry</title><addtitle>J Enzyme Inhib Med Chem</addtitle><description>This study reports the synthesis, characterisation and antimicrobial activity of five novel silver N-heterocyclic carbene (Ag-NHC) complexes obtained by N-propylphthalimide and N-methyldioxane substituted benzimidazolium salts with silver oxide. The reactions were performed at room temperature for 24 h in the absence of light. The obtained complexes were identified and characterised by
1
H and
13
C NMR, FT-IR and elemental analysis techniques. The minimum inhibitory concentration (MIC) of the complexes was determined for E. coli, P. aeruginosa, E. faecalis, S. aureus, C. tropicalis and C. albicans in vitro through agar and broth dilution. The results indicated that these complexes exhibit antimicrobial activity. In particular, complex 3 presented the significant broad spectrum antimicrobial activity.</description><subject>Anti-Infective Agents - chemical synthesis</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antimicrobial activity</subject><subject>benzimidazole</subject><subject>Benzimidazoles - chemistry</subject><subject>Carbon-13 Magnetic Resonance Spectroscopy</subject><subject>Methane - analogs & derivatives</subject><subject>Methane - chemical synthesis</subject><subject>Methane - chemistry</subject><subject>Methane - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>N-heterocyclic carbene</subject><subject>Proton Magnetic Resonance Spectroscopy</subject><subject>Silver - chemistry</subject><subject>silver complex</subject><issn>1475-6366</issn><issn>1475-6374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EoqXwE0A-ciCL7dhOwgmo-JIquMDZGjsTrZFjL3Z2IT3zw_Fqtz1ymg89M-9oXkKec7ZpORtec9kp3Wq9EYzrDedKcyYekMtjv9FtJx_e51pfkCel_GRMcMHlY3Ih9NB3TOpL8vc9xls_-xFuU_D7ubFQcKQxHTDQ4sMBM_3abHHBnNzqgnfUQbYYkbo07wL-wfKGljUuWyy-vKJuCxlcxX2BxadIIY7UR3rwS061WKqYy8l6CLRyvvbXp-TRBKHgs3O8Ij8-fvh-_bm5-fbpy_W7m8ZJ3i7NoAB6xgfGezs5KzgwmLi23YR6skq1mqMC1tlB1g8J28PYD9COTKAbneLtFXl52rvL6dcey2JmXxyGABHTvhjeC6lkx7SsqDqh9dZSMk5ml_0MeTWcmaMB5s4AczTAnA2ocy_OEns743g_dffxCrw9AT5OKc_wO-UwmgXWkPKUITpfjvv_p_EPO-yYiw</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Sarı, Yakup</creator><creator>Akkoç, Senem</creator><creator>Gök, Yetkin</creator><creator>Sifniotis, Vicki</creator><creator>Özdemir, İlknur</creator><creator>Günal, Selami</creator><creator>Kayser, Veysel</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Benzimidazolium-based novel silver N-heterocyclic carbene complexes: synthesis, characterisation and in vitro antimicrobial activity</title><author>Sarı, Yakup ; Akkoç, Senem ; Gök, Yetkin ; Sifniotis, Vicki ; Özdemir, İlknur ; Günal, Selami ; Kayser, Veysel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-95aa8019018bfcb21a0af16b7fe6fb55361e5a07b941092b8ad89a3d02ecdc513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Anti-Infective Agents - chemical synthesis</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antimicrobial activity</topic><topic>benzimidazole</topic><topic>Benzimidazoles - chemistry</topic><topic>Carbon-13 Magnetic Resonance Spectroscopy</topic><topic>Methane - analogs & derivatives</topic><topic>Methane - chemical synthesis</topic><topic>Methane - chemistry</topic><topic>Methane - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>N-heterocyclic carbene</topic><topic>Proton Magnetic Resonance Spectroscopy</topic><topic>Silver - chemistry</topic><topic>silver complex</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarı, Yakup</creatorcontrib><creatorcontrib>Akkoç, Senem</creatorcontrib><creatorcontrib>Gök, Yetkin</creatorcontrib><creatorcontrib>Sifniotis, Vicki</creatorcontrib><creatorcontrib>Özdemir, İlknur</creatorcontrib><creatorcontrib>Günal, Selami</creatorcontrib><creatorcontrib>Kayser, Veysel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of enzyme inhibition and medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarı, Yakup</au><au>Akkoç, Senem</au><au>Gök, Yetkin</au><au>Sifniotis, Vicki</au><au>Özdemir, İlknur</au><au>Günal, Selami</au><au>Kayser, Veysel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Benzimidazolium-based novel silver N-heterocyclic carbene complexes: synthesis, characterisation and in vitro antimicrobial activity</atitle><jtitle>Journal of enzyme inhibition and medicinal chemistry</jtitle><addtitle>J Enzyme Inhib Med Chem</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>31</volume><issue>6</issue><spage>1527</spage><epage>1530</epage><pages>1527-1530</pages><issn>1475-6366</issn><eissn>1475-6374</eissn><abstract>This study reports the synthesis, characterisation and antimicrobial activity of five novel silver N-heterocyclic carbene (Ag-NHC) complexes obtained by N-propylphthalimide and N-methyldioxane substituted benzimidazolium salts with silver oxide. The reactions were performed at room temperature for 24 h in the absence of light. The obtained complexes were identified and characterised by
1
H and
13
C NMR, FT-IR and elemental analysis techniques. The minimum inhibitory concentration (MIC) of the complexes was determined for E. coli, P. aeruginosa, E. faecalis, S. aureus, C. tropicalis and C. albicans in vitro through agar and broth dilution. The results indicated that these complexes exhibit antimicrobial activity. In particular, complex 3 presented the significant broad spectrum antimicrobial activity.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>26987046</pmid><doi>10.3109/14756366.2016.1156102</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of enzyme inhibition and medicinal chemistry, 2016-11, Vol.31 (6), p.1527-1530 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antimicrobial activity benzimidazole Benzimidazoles - chemistry Carbon-13 Magnetic Resonance Spectroscopy Methane - analogs & derivatives Methane - chemical synthesis Methane - chemistry Methane - pharmacology Microbial Sensitivity Tests N-heterocyclic carbene Proton Magnetic Resonance Spectroscopy Silver - chemistry silver complex |
| title | Benzimidazolium-based novel silver N-heterocyclic carbene complexes: synthesis, characterisation and in vitro antimicrobial activity |
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