Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing
We examined serum and erythrocyte lead and manganese levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL), which contains over 1000 registrants including over 200 cases of Alzheimer's disease (AD) and 100 mildly cognitively impaired (MCI) individuals. After...
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| Veröffentlicht in: | Metallomics 2016-06, Vol.8 (6), p.628-632 |
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| creator | Hare, Dominic J Faux, Noel G Roberts, Blaine R Volitakis, Irene Martins, Ralph N Bush, Ashley I |
| description | We examined serum and erythrocyte lead and manganese levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL), which contains over 1000 registrants including over 200 cases of Alzheimer's disease (AD) and 100 mildly cognitively impaired (MCI) individuals. After correcting for confounding effects of age, collection site and sex, we found a significant decrease in serum manganese levels in AD subjects compared to healthy controls. Analysis of smaller subset of erythrocytes revealed no difference in either lead or manganese levels in AD. Although lead and manganese have neurotoxic effects and may be involved in AD pathology, our results showed that neither metal in serum nor erythrocytes are suitable biomarkers in our cohort. However, prospective studies might reveal whether the burden of either metal modifies disease outcomes.
A report on lead and manganese in serum and erythrocytes in one of the world's largest Alzheimer's disease cohorts. |
| doi_str_mv | 10.1039/c6mt00019c |
| format | Article |
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A report on lead and manganese in serum and erythrocytes in one of the world's largest Alzheimer's disease cohorts.</description><subject>Aged</subject><subject>Aging - physiology</subject><subject>Alzheimer Disease - blood</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Biomarkers - blood</subject><subject>Cognitive Dysfunction - blood</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Erythrocytes - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Lead - blood</subject><subject>Male</subject><subject>Manganese - blood</subject><issn>1756-5901</issn><issn>1756-591X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1u1DAUhS0EoqWwYQ_yDoQYsJOJ7bAbRvRHGsSCIrGLPPZ1xmAnU1-nUng6Ho00U6be2NL5ztG9PoS85OwDZ2X90YiYGWO8No_IKZeVWFQ1__n4-Gb8hDxD_MWYWDJWPSUnhahFUYvqlPzdgLZUd5ZG3bW6AwQa4BYCUt9RhDTEWYU05l3qzZhhVlbhzw58hPQGqfUIevLNKT5Yavq289nfAvVxr32K0OVPNAEOISN1qY8074CuBsxJB687ehV167v2Pf3s-6jTb0g4x228A8xjAHoedIs7v6ff82BH2ju6amGyPCdPnA4IL-7vM_Lj_Mv1-nKx-XZxtV5tFqaUKi_k0kBh3JZrrrRSzEqmrLSVEBJUoZzTbssELJdyOmW9da4WsmJGcCMMlLw8I28PufvU3wzTUE30aCCE6c_6ARuumBKFVEUxoe8OqEk9YgLX7JOfthobzpq7xpq1-Ho9N7ae4Nf3ucM2gj2i_yuagFcHIKE5qg-Vl_8AQI2fNg</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Hare, Dominic J</creator><creator>Faux, Noel G</creator><creator>Roberts, Blaine R</creator><creator>Volitakis, Irene</creator><creator>Martins, Ralph N</creator><creator>Bush, Ashley I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20160601</creationdate><title>Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing</title><author>Hare, Dominic J ; Faux, Noel G ; Roberts, Blaine R ; Volitakis, Irene ; Martins, Ralph N ; Bush, Ashley I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-74ce2cfb1a18a880d708d7d5667e828ffafb06e44777739bff96750c61c6ce313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aging - physiology</topic><topic>Alzheimer Disease - blood</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Biomarkers - blood</topic><topic>Cognitive Dysfunction - blood</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Erythrocytes - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Lead - blood</topic><topic>Male</topic><topic>Manganese - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hare, Dominic J</creatorcontrib><creatorcontrib>Faux, Noel G</creatorcontrib><creatorcontrib>Roberts, Blaine R</creatorcontrib><creatorcontrib>Volitakis, Irene</creatorcontrib><creatorcontrib>Martins, Ralph N</creatorcontrib><creatorcontrib>Bush, Ashley I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Metallomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hare, Dominic J</au><au>Faux, Noel G</au><au>Roberts, Blaine R</au><au>Volitakis, Irene</au><au>Martins, Ralph N</au><au>Bush, Ashley I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing</atitle><jtitle>Metallomics</jtitle><addtitle>Metallomics</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>8</volume><issue>6</issue><spage>628</spage><epage>632</epage><pages>628-632</pages><issn>1756-5901</issn><eissn>1756-591X</eissn><abstract>We examined serum and erythrocyte lead and manganese levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL), which contains over 1000 registrants including over 200 cases of Alzheimer's disease (AD) and 100 mildly cognitively impaired (MCI) individuals. After correcting for confounding effects of age, collection site and sex, we found a significant decrease in serum manganese levels in AD subjects compared to healthy controls. Analysis of smaller subset of erythrocytes revealed no difference in either lead or manganese levels in AD. Although lead and manganese have neurotoxic effects and may be involved in AD pathology, our results showed that neither metal in serum nor erythrocytes are suitable biomarkers in our cohort. However, prospective studies might reveal whether the burden of either metal modifies disease outcomes.
A report on lead and manganese in serum and erythrocytes in one of the world's largest Alzheimer's disease cohorts.</abstract><cop>England</cop><pmid>26962965</pmid><doi>10.1039/c6mt00019c</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1756-5901 |
| ispartof | Metallomics, 2016-06, Vol.8 (6), p.628-632 |
| issn | 1756-5901 1756-591X |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Royal Society Of Chemistry Journals 2008- |
| subjects | Aged Aging - physiology Alzheimer Disease - blood Alzheimer Disease - diagnosis Biomarkers - blood Cognitive Dysfunction - blood Cognitive Dysfunction - diagnosis Erythrocytes - metabolism Female Humans Image Processing, Computer-Assisted Lead - blood Male Manganese - blood |
| title | Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing |
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